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The map label for this gene is hemX [H]

Identifier: 22124294

GI number: 22124294

Start: 423183

End: 424316

Strand: Reverse

Name: hemX [H]

Synonym: y0379

Alternate gene names: 22124294

Gene position: 424316-423183 (Counterclockwise)

Preceding gene: 22124295

Following gene: 22124293

Centisome position: 9.22

GC content: 50.62

Gene sequence:

>1134_bases
ATGCCCAATATGACGGAACAAAATACCCCATCCGCACCAGTGGAAGAGCCAACCACTGCGGTTGAGAGGCCCCAACAGCC
AGAACCAAAAGGCCACCGTGAAAAACGGACTGGCCCAATTCTGGGTGTTATCGCTATCGCCTTGGTAATAGCACTGGGAG
CGGGGCTTTATTATCATGGACAGCAGCAGGCCCAGTTACAGAGTGCGGAGAATATTGCGCTGCAAGAGCAGTTAGTGGCA
CTAAAACAGACGCTATTGCAGGAAAAACAGCAACTGGAGTCCTTACTGCAGCAGCAGGGGAAAGCGCTGGAGTCGGCAGA
AAATCAACAAGCCTCTCTGACACGCCAGCTCAATGAATTACAAGAAAAAGTCGCGACTATTTCAGGCAGCGATGCCAAAA
CCTGGCTGCTGGCTCAGGCTGATTTCCTGGTGAAAATGGCCGGGCGCAAGCTGTGGAGTGATCAAGATGTCACCACCGCG
GTCACCTTACTGAAAAGCGCCGATGCCAGTCTGGCCGATATGAATGACCCAAGTCTTATCGATGTCCGCCGCGCGATTAC
AGAAGATATCAGTGCACTCTCTGCCGTCAGTCAGGTGGATTTTGACGGTATTATCCTCAAGTTAAACCAGTTGTCTAATC
AAGTAGATAACTTGCGTTTGGCCGATAACAATATTGATGACTCCCCCATGGATGCCAACAGTGACGAACTCTCCAGTTCA
CTCTCTGAATGGCGTCAGAATCTGAGCAAAAGCTGGCACAGCTTTATGTCTGATTTCATTAGTATTCGCCGCCGTGATAG
TAGCGCGGAACCTTTGCTGGCACCGAATCAGGACGTGTATCTGCGAGAAAACATTCGCTCCCGCCTGCTGGTTGCCGCTC
AGGCCGTCCCCCGCCATCAAGACGAAGTTTATAAGCAGTCATTGGAAACGATTTCTACGTGGGTCCGCGCTTATTTTGAT
GTGAACGACCCGAGTACCAAGGCGTTCTTGGATGAGCTGGAAAATCTGAGCCAGCAACCTATCTCAATGGACGTGCCGGA
TCAATTGAAAAGCCAGCCAATACTGGAAAAATTGATGCAAACCAGGGTCCGTAACTTACTGGCACAAACGCCAGTTGATG
CTCAGGGGGAATAA

Upstream 100 bases:

>100_bases
AATGGGGTGGACGGAGGTCCGGGTAGCAGAAAATGCCGATAATGACGCACTGATCCGTGCGTTACAAGACCTTCAATAAA
CCTAAAACCTGACTTATGGG

Downstream 100 bases:

>100_bases
ATATGCTGCGAGTCTTGCTGTTATTCCTTGTTTTAACTGTGGGTATCGTGCTTGGCCCAATGTTGGCCGGGCATCAGGGT
TATGTGCTGATCCAGACTGA

Product: putative uroporphyrinogen III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPNMTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVA
LKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTA
VTLLKSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSS
LSEWRQNLSKSWHSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFD
VNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE

Sequences:

>Translated_377_residues
MPNMTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVA
LKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTA
VTLLKSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSS
LSEWRQNLSKSWHSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFD
VNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE
>Mature_376_residues
PNMTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHGQQQAQLQSAENIALQEQLVAL
KQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNELQEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAV
TLLKSADASLADMNDPSLIDVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSSL
SEWRQNLSKSWHSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQDEVYKQSLETISTWVRAYFDV
NDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQTRVRNLLAQTPVDAQGE

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=367, Percent_Identity=68.1198910081744, Blast_Score=475, Evalue=1e-135,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 41975; Mature: 41843

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNMTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHCCC
QQQAQLQSAENIALQEQLVALKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTLLKSADASLADMNDPSLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCHHH
DVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSS
HHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHCEEECCCCCCCCCCCCCHHHHHHH
LSEWRQNLSKSWHSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
DEVYKQSLETISTWVRAYFDVNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHH
TRVRNLLAQTPVDAQGE
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PNMTEQNTPSAPVEEPTTAVERPQQPEPKGHREKRTGPILGVIAIALVIALGAGLYYHG
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCHHCCC
QQQAQLQSAENIALQEQLVALKQTLLQEKQQLESLLQQQGKALESAENQQASLTRQLNEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKVATISGSDAKTWLLAQADFLVKMAGRKLWSDQDVTTAVTLLKSADASLADMNDPSLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCHHH
DVRRAITEDISALSAVSQVDFDGIILKLNQLSNQVDNLRLADNNIDDSPMDANSDELSSS
HHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHCEEECCCCCCCCCCCCCHHHHHHH
LSEWRQNLSKSWHSFMSDFISIRRRDSSAEPLLAPNQDVYLRENIRSRLLVAAQAVPRHQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
DEVYKQSLETISTWVRAYFDVNDPSTKAFLDELENLSQQPISMDVPDQLKSQPILEKLMQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHH
TRVRNLLAQTPVDAQGE
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]