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The map label for this gene is ilvY [H]

Identifier: 22124260

GI number: 22124260

Start: 380665

End: 381549

Strand: Reverse

Name: ilvY [H]

Synonym: y0344

Alternate gene names: 22124260

Gene position: 381549-380665 (Counterclockwise)

Preceding gene: 22124264

Following gene: 22124259

Centisome position: 8.29

GC content: 52.77

Gene sequence:

>885_bases
GTGATGGATTTACGTGACCTGAAAGTATTTCTGCATCTGGCTGAAAGCCGCCATTTTGGGCGCTCGGCCAAAGCTATGCA
CGTCAGTCCCTCTACGCTTTCCCGCCAGATCCAGCGGCTGGAAGAGACTATCGGCCAGCCCCTGTTTTTACGCGATAACC
GCACAGTGCAATTAACCGATGCGGGTAACCAATTAAAGGCGTTTGCCCAACAAACCCTCTTACAATATCAACAGTTGCTC
CATGCATTGGGCCAGCACGGTCCTTCCCTAAGCGGTGAATTGCGCTTATTTTGCTCCGTTACCGCCGCTTACAGCCACTT
GCCGCCAATTTTGGACCGCTTTCGCGCACGCCATCCGTTGGTTGAAATTAAACTCACCACGGGTGATGCCGCCGATGCAG
TCAATAAAGTGCAATCCAATGAGGCTGATTTGGGGATCGCCGGCCGCCCTGAAGTGCTCCCCACCAGCGTGGCCTTTACC
CAGATTGGTGAAATCCCATTAGTATTGATTGCCCCTGCACTGCCGTGTGCGGTGCGTTCGCAAGTGGCGGTTGAAAAACC
GGATTGGGCGATGATCCCGTTTATCTTGCCGGAACACGGGCCGTCACGAAAACGTATCGATTTATGGTTCCGTCGCCAGC
GTATAACTAACCCATTGATTTATGCCACGGTGTCCGGCCATGAAGCGATTGTTTCCATGGTGGCATTGGGTTGCGGTGTC
GCCCTGATCCCGTCGGTAGTGGTGGATAACAGCCCGGAGCCAGTCCGTAACCGTATTTCTCTGCTAGATGATGTCTCGTT
AGTCGAGCCATTTGAGTTGGGGGTTTGTGTACCGAAAAAACGGCTCCAAGAGCCGTTGATTGATGCATTTTGGGGATTGT
TATAA

Upstream 100 bases:

>100_bases
ATTGCGGAAATTGATATATTAACAATGTGATATTGCAGTTTCTGCAATACACCCGATTTCTTATGCAATACACTACATCA
TCTCAACCAAGAGGCTGTCT

Downstream 100 bases:

>100_bases
TCCTTGGTGTCTCAATAGCATAAATATCAGTGACACCATTGATAATAATATTGATTAAGCGGCAATAACACGGCCTATTG
AATAACAGCTAATCATTGCA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MMDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLL
HALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFT
QIGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGV
ALIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL

Sequences:

>Translated_294_residues
MMDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLL
HALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFT
QIGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGV
ALIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
>Mature_294_residues
MMDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLL
HALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFT
QIGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGV
ALIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=73.7201365187713, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788887, Length=248, Percent_Identity=28.6290322580645, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI2367136, Length=276, Percent_Identity=26.8115942028986, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=29.8387096774194, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790399, Length=264, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=29.3413173652695, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787530, Length=271, Percent_Identity=24.3542435424354, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=27.7551020408163, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=258, Percent_Identity=24.4186046511628, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=254, Percent_Identity=27.5590551181102, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790262, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=24.8275862068966, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789440, Length=148, Percent_Identity=28.3783783783784, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693193, Length=129, Percent_Identity=32.5581395348837, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789204, Length=299, Percent_Identity=24.4147157190635, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=252, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=23.6947791164659, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32512; Mature: 32512

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTD
CCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEECCCEEEEEC
AGNQLKAFAQQTLLQYQQLLHALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCCCE
VEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQIGEIPLVLIAPALPCAVRS
EEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHC
QVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGV
CCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCH
ALIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTD
CCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEECCCEEEEEC
AGNQLKAFAQQTLLQYQQLLHALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCCCE
VEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQIGEIPLVLIAPALPCAVRS
EEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHC
QVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGV
CCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCH
ALIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]