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The map label for this gene is menA [H]

Identifier: 22124211

GI number: 22124211

Start: 311719

End: 312648

Strand: Reverse

Name: menA [H]

Synonym: y0293

Alternate gene names: 22124211

Gene position: 312648-311719 (Counterclockwise)

Preceding gene: 22124212

Following gene: 22124210

Centisome position: 6.8

GC content: 48.82

Gene sequence:

>930_bases
ATGAAGCGAAAAATGAGCCTATCAATCAACACCAGCCAAACCCAGGCTTGGCTGGAAAGCCTACGACCACGCACCCTACC
ATTGGCGTTCGCCTCTATCGTTACCGGTTCAGCTCTGGCTGTCTGGCTCGATAGTTTTAAACCCGCCGTGGCACTATTAG
CCCTATTAACTGCCGGTCTACTGCAAATTCTATCCAATCTGGCTAACGACTATGGCGATGCGGTGAAAGGCAGCGATACC
GAAGAACGTATCGGGCCATTACGCGGTATGCAAAAAGGGATAATTAGCCACCAGCAAATGAAAGTGGCGCTAATTATCAC
CGTGATCTTAACAATCATTTCAGGTATCGCCCTCATTGCCGTCGCCTGTGAAAAGCCCAGCGATATTCTTGGATTTTTAC
TGCTTGGCCTGATGGCGATTGTTGCCGCCATTACTTACACCGTGGGGAGAAAACCCTATGGTTATATGGGATTGGGTGAT
ATTTCGGTATTGGTATTCTTCGGTTGGTTAAGCGTCGCAGGGACCTATTATCTTCAAGCTGGCCACTTTGATAGCATCGT
CATGCTGCCGGCCACGGCCTGTGGTTTACTGGCCACGGCGGTATTAAATATTAATAACTTACGCGATATCGAAAATGATA
AAGCAAATGGCAAAAATACGCTGGCAGTCCGTCTAGGGCCTGTCGTAGCACGCTATTATCATGCGCTGTTAATTGGTGCC
GCCATCTTCTGCCTGGCACTCTTCAGCATTCTCCATCTGCACAGTTGGCACGGTTGGATCTTTTTATTAGCGATCCCATT
ACTGGGAAAACATGCGCTGTTTGTTTTACGGGACCCTACCGCAGCAGGTATGCGCCCTATGCTCGAGCAGATGGTGAAAG
CCGCTTTACTGACCAATATCCTGTTTGCTGTGGGCCTGGTATTCAGTTAA

Upstream 100 bases:

>100_bases
TCATAATTTTTTGACATGATAATTTTATTAACATTATTTCCATTTGGCATGATCCCGTTTTCTTACACGCCGAGATTAAG
GCGGACCAGACTCCTATTGA

Downstream 100 bases:

>100_bases
TACGGCTTGTTTATCATAGAAAGGTCTCCGGGCCATTAGCGGCTCAAGGTAACTTGAATAAATTTAACAATTGATGATTT
TGCCAACAGCGGCCAGAAAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKRKMSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGLLQILSNLANDYGDAVKGSDT
EERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIAVACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGD
ISVLVFFGWLSVAGTYYLQAGHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGA
AIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNILFAVGLVFS

Sequences:

>Translated_309_residues
MKRKMSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGLLQILSNLANDYGDAVKGSDT
EERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIAVACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGD
ISVLVFFGWLSVAGTYYLQAGHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGA
AIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNILFAVGLVFS
>Mature_309_residues
MKRKMSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGLLQILSNLANDYGDAVKGSDT
EERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIAVACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGD
ISVLVFFGWLSVAGTYYLQAGHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGA
AIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNILFAVGLVFS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=307, Percent_Identity=27.0358306188925, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790365, Length=298, Percent_Identity=68.1208053691275, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17737429, Length=293, Percent_Identity=28.3276450511945, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33239; Mature: 33239

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKMSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGL
CCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LQILSNLANDYGDAVKGSDTEERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGDISVLVFFGWLSVAGTYYLQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEC
GHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGA
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
AIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LFAVGLVFS
HHHHHHHCC
>Mature Secondary Structure
MKRKMSLSINTSQTQAWLESLRPRTLPLAFASIVTGSALAVWLDSFKPAVALLALLTAGL
CCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LQILSNLANDYGDAVKGSDTEERIGPLRGMQKGIISHQQMKVALIITVILTIISGIALIA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VACEKPSDILGFLLLGLMAIVAAITYTVGRKPYGYMGLGDISVLVFFGWLSVAGTYYLQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEC
GHFDSIVMLPATACGLLATAVLNINNLRDIENDKANGKNTLAVRLGPVVARYYHALLIGA
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
AIFCLALFSILHLHSWHGWIFLLAIPLLGKHALFVLRDPTAAGMRPMLEQMVKAALLTNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LFAVGLVFS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]