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The map label for this gene is yjcE [H]

Identifier: 22124158

GI number: 22124158

Start: 253332

End: 255002

Strand: Reverse

Name: yjcE [H]

Synonym: y0238

Alternate gene names: 22124158

Gene position: 255002-253332 (Counterclockwise)

Preceding gene: 22124159

Following gene: 22124155

Centisome position: 5.54

GC content: 52.42

Gene sequence:

>1671_bases
GTGTGGAGTCTTAAGGAAAGCATGGAAATCTTTTTTACAATCCTCATTTTGATTTTAGTGGTATCGCTTTCTGGCGTTGT
CACTCGAATGTTACCGTTTCAAGTCCCTCTTCCTCTGATGCAAATTGTCTGCGGTGCTTTGCTGGCTTGGCCCAATTTTG
GGTTGCATGTCAATTTTGACCCAGAGCTATTCCTGGTGCTGTTCATTCCGCCGCTGCTATTTGCCGATGGTTGGAAAACA
CCGACACGGGAATTTATTCATCATGGGCGAGAAATATTGGGTCTGGCACTGGCATTAGTTTTGGTGACCATCGTGGGTAT
CGGTTATCTGATTTACTGGATGGTACCGGGTATTCCGCTGGTGGCGGCCTTTGCGTTGGCGGCGGTGTTATCGCCGACCG
ATGCCGTAGCGCTATCCGGTATCGTGGGTAAAGGGCGGATCCCGAAATCCATTATGGGCGTACTGGAAGGAGAGGCGTTG
ATGAACGATGCCTCCGGTCTGGTGGCGCTGAAATTTGCCATTGCAGTGGCGATGGGGACGATGATCTTTACCGTTTCCGG
TGCCACGCTGGAGTTCTTAAAAGTCGCGATCGGTGGTCTGCTGGCGGGTGTGGCGATAACCTGGTTGTACAGTAAATCGC
TGCGTATTATGAGCCGCTGGAGCGGCGATGATCCAGCGACACAAATTGTCTTGTTGCTGTTGTTACCGTTCGCCTCCTAT
TTGGTTGCAGAGCACCTTGGCGTCTCCGGCATCTTGGCGGCGGTGGCGGCGGGGATGACCATCAGCCAGTCGGGTATTAT
TCGTAACGCCCCGTTGGCGATGCGGCTGCGTGCTGACAGTGTGTGGTCGATGTTGGAGTTTGTGTTTAACGGCATGGTAT
TTATCCTGTTGGGTCTGCAATTACCGGGGATCCTCGAAACCTCCATCACACAAGCAGAACTGGACCCGACCATTCAAACC
TGGAACCTGTTCGCTGATGTTGCCATTATTTATGGCGCGTTGTTGTTGCTGCGTTTCGGTTGGTTGTGGTCGATGAAGAA
AATCAGTAAGCGGGTGCTGACCAAGCGGCCACTGCAATTTAGCGATTACACCACCCGTGAGCTGTGGGTTGCTTCATTCG
CCGGGGTGCGTGGGGCGATAACCCTTGCCGGTGTGCTGTCGATTCCCTTATTCCTTAGCGATGGCTCAGCCTTCCCATCC
CGCTACCAATTGGTCTTTATCGCCACTGGCGTGATCTTGTTGTCGGTGATTATTGGGGTGATCGCCTTGCCGCCGTTATT
ACGCGGGGTGGTGGTTGCGGATAAGAGTGCCAGCCGTGAAGAAATTCGTCTGGCTCGGGCGGCGATGGCAGAAGTCGCGA
TTGTTAGCCTGAATAAGATGGAAGAGCGGCTAATGACCAGTAGTGAGGAGAATATTGACTCAGAGTTACTGAAGGAGGTT
AGCTCGCGGGTCATTGGTACATTGCGGCGGCGCACGGGCAGTAAAGATGAAGTTGAGAATACGCTGCTGATTGAAAATCT
GGAACGGCGTTTTCGCTTAACCGCCCTGCGGGCCGAACGTGGTGAGTTATATCACCTGCGCGCCACGCAGAAAATCAGCA
ATGAAACCCTGCAAAAGCTGCTGCATGATTTGGATTTGCTGGAAGCGTTGCTGATCGAAAAAGAAGGTTAA

Upstream 100 bases:

>100_bases
GGTTGTCACAGGTTTTTCCCCCGCTTCACAAAAAAGTGATCTACTATCGAAAGCGATGCCCGGCCTTGGCTTCGGGCGGG
TATGATCACAAAATTATGTC

Downstream 100 bases:

>100_bases
TATCTTACGGACGGGGCTAATTTGGCCCCGTTTACCGATTACATGAGACTTAAAACGTAATCGACTCATCGGGGTTTGTC
AGCCGTCTGACAGTACTGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MWSLKESMEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKT
PTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEAL
MNDASGLVALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASY
LVAEHLGVSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQT
WNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPS
RYQLVFIATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEV
SSRVIGTLRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG

Sequences:

>Translated_556_residues
MWSLKESMEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKT
PTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEAL
MNDASGLVALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASY
LVAEHLGVSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQT
WNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPS
RYQLVFIATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEV
SSRVIGTLRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG
>Mature_556_residues
MWSLKESMEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFDPELFLVLFIPPLLFADGWKT
PTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPLVAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEAL
MNDASGLVALKFAIAVAMGTMIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASY
LVAEHLGVSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQLPGILETSITQAELDPTIQT
WNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQFSDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPS
RYQLVFIATGVILLSVIIGVIALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEV
SSRVIGTLRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKLLHDLDLLEALLIEKEG

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=459, Percent_Identity=23.3115468409586, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI15529998, Length=455, Percent_Identity=23.956043956044, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI41872703, Length=506, Percent_Identity=24.1106719367589, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI27734935, Length=267, Percent_Identity=23.9700374531835, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI14211919, Length=260, Percent_Identity=24.2307692307692, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI294997330, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI110227626, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI5454070, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=75, Blast_Score=831, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980847, Length=396, Percent_Identity=23.989898989899, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=385, Percent_Identity=23.8961038961039, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=445, Percent_Identity=21.5730337078652, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71999819, Length=445, Percent_Identity=21.5730337078652, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=401, Percent_Identity=22.1945137157107, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=388, Percent_Identity=21.6494845360825, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=401, Percent_Identity=22.1945137157107, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=21.9584569732938, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=21.9584569732938, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=364, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221473215, Length=446, Percent_Identity=21.52466367713, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364513, Length=440, Percent_Identity=21.5909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=440, Percent_Identity=21.5909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473212, Length=384, Percent_Identity=22.3958333333333, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281360447, Length=562, Percent_Identity=21.8861209964413, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510734, Length=390, Percent_Identity=22.0512820512821, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221510738, Length=390, Percent_Identity=22.0512820512821, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60800; Mature: 60800

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSLKESMEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
PELFLVLFIPPLLFADGWKTPTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPL
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGLVALKFAIAVAMGT
HHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASY
HHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LVAEHLGVSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQ
HHHHHCCHHHHHHHHHHCCEECCCCCEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHC
LPGILETSITQAELDPTIQTWNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQF
CCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFIATGVILLSVIIGV
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEV
HHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SSRVIGTLRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
LHDLDLLEALLIEKEG
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MWSLKESMEIFFTILILILVVSLSGVVTRMLPFQVPLPLMQIVCGALLAWPNFGLHVNFD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
PELFLVLFIPPLLFADGWKTPTREFIHHGREILGLALALVLVTIVGIGYLIYWMVPGIPL
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VAAFALAAVLSPTDAVALSGIVGKGRIPKSIMGVLEGEALMNDASGLVALKFAIAVAMGT
HHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIFTVSGATLEFLKVAIGGLLAGVAITWLYSKSLRIMSRWSGDDPATQIVLLLLLPFASY
HHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LVAEHLGVSGILAAVAAGMTISQSGIIRNAPLAMRLRADSVWSMLEFVFNGMVFILLGLQ
HHHHHCCHHHHHHHHHHCCEECCCCCEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHC
LPGILETSITQAELDPTIQTWNLFADVAIIYGALLLLRFGWLWSMKKISKRVLTKRPLQF
CCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SDYTTRELWVASFAGVRGAITLAGVLSIPLFLSDGSAFPSRYQLVFIATGVILLSVIIGV
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IALPPLLRGVVVADKSASREEIRLARAAMAEVAIVSLNKMEERLMTSSEENIDSELLKEV
HHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SSRVIGTLRRRTGSKDEVENTLLIENLERRFRLTALRAERGELYHLRATQKISNETLQKL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHH
LHDLDLLEALLIEKEG
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]