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The map label for this gene is aceB [H]

Identifier: 22123937

GI number: 22123937

Start: 19456

End: 21087

Strand: Direct

Name: aceB [H]

Synonym: y0015

Alternate gene names: 22123937

Gene position: 19456-21087 (Clockwise)

Preceding gene: 22123935

Following gene: 22123938

Centisome position: 0.42

GC content: 47.98

Gene sequence:

>1632_bases
GTGGCAGCAGTAACATTGGGAAGGGGAATAGCAATGAGACAACAGTTAGCGGGCACAGAGTTAGTTTTCACCCAGCCTTT
TAATGCTGCTGAGCGGCAGGTTTTACCGGATAAAGCCATCGAGTTTCTAACCGAATTAGTGGTGAAATTTAGCGAATCGC
GTAACCAACTCCTTGCCACAAGGGCATCTTGGCAGCAAACCATCGATCAGGGGGCGTTACCCGATTTTATTTTGGAAACT
AATTCCATTCGTGATGGTGATTGGAAAATCCAAGGTATTCCTGCTGACTTACGCGATCGTAGAGTTGAGATCACCGGGCC
AGTAGAGCGGAAAATGGTGATCAATGCGCTTAATGCCAACGTAAAAGTTTTTATGGCGGATTTCGAAGATTCACTGGCAC
CCAGTTGGGATAAAGTGATTGATGGTCAAATTAATCTACATGATGCGGTGAAAGGGACAATTTCCTATACGAATGAATCG
GGCAAGGTCTATCAATTAAAACCTAATCCCGCGGTATTGATTGCACGTGTTCGTGGCCTGCACTTACCGGAAAAACATGT
TAAATGGCAGGACGAGGCGATTCCCGGTGGTTTATTCGATTTCGCTTTGTATTTCTACCATAACTATCAGCAACTGCTGG
CGAAGGGCAGCGGCCCTTATTTCTATTTGCCGAAGATGCAGTCATACCAGGAAGCCGCTTGGTGGAGCGATGTGTTCAAT
TTTACCGAGCAGCGCTTTGGTCTATCGCAGGGCACCATTAAGGCGACGGTATTAATTGAGACATTACCCGCCGTTTTCCA
AATGGATGAAATTCTCTACCACCTGCGCCACCACATTGTTGGTCTGAATTGTGGGCGCTGGGACTATATCTTTAGCTATA
TAAAAACATTGAAAAACCACCCTGACCGCGTGTTACCAGATCGCCAGTCAGTCACGATGAATAAACCTTTTCTTAGCGCG
TATTCCCGTTTGTTGATCAAGACATGCCATAAACGTGGCGCTTTGGCGATGGGGGGAATGGCCGCCTTCATCCCGGATAA
AGACGCAGAAAAGAATAAGTTGGTGTTGGATAAAGTTCGTGCCGACAAAGAGTTAGAAGCCAGTAACGGCCACGATGGAA
CTTGGGTGGCGCATCCGGGCTTGGCAGATACGGTGATGGACGTTTTTAACAAAGTATTAGGTTCTCGGCCTAATCAATTA
GAGGTTAGCCGCGAACAGGATAAACCTATCACCGCCGCTGAGTTGCTGGAACCTTGTTCTGGCGAGCGCACTGAAGCAGG
GATGCGGGCCAATATCAGAGTCGCGGTGCAGTACATTGAAGCATGGATATCGGGTAATGGTTGTGTGCCGATTTATGGCT
TGATGGAGGATGCGGCTACTGCAGAGATTTCCCGCACTTCTATCTGGCAATGGATACATCATCAGAAAAGCCTCAGTAAT
GGCCAGACGGTGACTAAAGAGCTGTTCCGCAGCATGTTGAGTGAAGAAATTCAGGTTGTGAAGCTTGAGCTTGGCGCAGA
GCGTTTTGATCGCGGGCGGTTTGAAGAAGCTGCACGCTTGATGGAGCGTATTACAACACAAGACGAGCTTATCGACTTCC
TGACGTTGCCGGGCTATGCATTGCTTGCCTGA

Upstream 100 bases:

>100_bases
TTTCTGTCGGGTGAAAAATAACCATAAAATTCTGCCTTTTTTACTGGCAGGGACACGTTACCTGATGATAATCCAAGAGT
GACGCGAGGTCAGCGTTAAG

Downstream 100 bases:

>100_bases
GCCATCCTATTGAACCCTACAAAATTGAATTATAAGGAACATCGCCATGACGATCTCTCGTACTCAACAAATTCAGCAGT
TGGAACAGGAATGGACATCG

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAAVTLGRGIAMRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNQLLATRASWQQTIDQGALPDFILET
NSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNES
GKVYQLKPNPAVLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFN
FTEQRFGLSQGTIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSA
YSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQL
EVSREQDKPITAAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSN
GQTVTKELFRSMLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA

Sequences:

>Translated_543_residues
MAAVTLGRGIAMRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNQLLATRASWQQTIDQGALPDFILET
NSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNES
GKVYQLKPNPAVLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFN
FTEQRFGLSQGTIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSA
YSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQL
EVSREQDKPITAAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSN
GQTVTKELFRSMLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA
>Mature_542_residues
AAVTLGRGIAMRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNQLLATRASWQQTIDQGALPDFILETN
SIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESG
KVYQLKPNPAVLIARVRGLHLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFNF
TEQRFGLSQGTIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQSVTMNKPFLSAY
SRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVRADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLE
VSREQDKPITAAELLEPCSGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSNG
QTVTKELFRSMLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYALLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=79.5497185741088, Blast_Score=894, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=518, Percent_Identity=49.8069498069498, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71982926, Length=412, Percent_Identity=51.9417475728155, Blast_Score=407, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324212, Length=522, Percent_Identity=46.7432950191571, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322222, Length=521, Percent_Identity=46.6410748560461, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 61299; Mature: 61168

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVTLGRGIAMRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNQLLAT
CCEEECCCCHHHHHHHCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASWQQTIDQGALPDFILETNSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNAN
HHHHHHHHHCCCCCHHHEECCCCCCCCEEEECCCCCHHCCEEEEECCHHHHHHHHHHCCC
VKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPAVLIARVRGL
EEEEEECCCCCCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEHHCC
HLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFN
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
FTEQRFGLSQGTIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNH
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
PDRVLPDRQSVTMNKPFLSAYSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVR
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCCCCCHHHHHH
ADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPITAAELLEPCS
CCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHCCCC
GERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GQTVTKELFRSMLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYA
CHHHHHHHHHHHHHHHHEEEEEHHCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCHH
LLA
HCC
>Mature Secondary Structure 
AAVTLGRGIAMRQQLAGTELVFTQPFNAAERQVLPDKAIEFLTELVVKFSESRNQLLAT
CEEECCCCHHHHHHHCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASWQQTIDQGALPDFILETNSIRDGDWKIQGIPADLRDRRVEITGPVERKMVINALNAN
HHHHHHHHHCCCCCHHHEECCCCCCCCEEEECCCCCHHCCEEEEECCHHHHHHHHHHCCC
VKVFMADFEDSLAPSWDKVIDGQINLHDAVKGTISYTNESGKVYQLKPNPAVLIARVRGL
EEEEEECCCCCCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEHHCC
HLPEKHVKWQDEAIPGGLFDFALYFYHNYQQLLAKGSGPYFYLPKMQSYQEAAWWSDVFN
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
FTEQRFGLSQGTIKATVLIETLPAVFQMDEILYHLRHHIVGLNCGRWDYIFSYIKTLKNH
HHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
PDRVLPDRQSVTMNKPFLSAYSRLLIKTCHKRGALAMGGMAAFIPDKDAEKNKLVLDKVR
CCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCEEECCEEEECCCCCCCCCCCHHHHHH
ADKELEASNGHDGTWVAHPGLADTVMDVFNKVLGSRPNQLEVSREQDKPITAAELLEPCS
CCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHCCCC
GERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKSLSN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GQTVTKELFRSMLSEEIQVVKLELGAERFDRGRFEEAARLMERITTQDELIDFLTLPGYA
CHHHHHHHHHHHHHHHHEEEEEHHCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCHH
LLA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]