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The map label for this gene is hasA [H]

Identifier: 21911387

GI number: 21911387

Start: 1880498

End: 1881757

Strand: Direct

Name: hasA [H]

Synonym: SpyM3_1851

Alternate gene names: 21911387

Gene position: 1880498-1881757 (Clockwise)

Preceding gene: 21911378

Following gene: 21911388

Centisome position: 98.95

GC content: 32.78

Gene sequence:

>1260_bases
GTGCCTATTTTTAAAAAAACTTTAATTGTTTTATCCTTTATTTGTTTGATATCTATCTTGATTTATCTAAATATGTATCT
ATTTGGAACATCAACTGTAGGAATTTATGGAGTAATATTAATAACCTATCTAGTTATTAAACTTGGATTATCTTTCCTTT
ATGAGCCATTTAAAGGAAATCCACATGACTATAAAGTTGCTGCTGTAATTCCTTCTTATAATGAAGATGCCGAGTCATTA
TTAGAAACACTTAAAAGTGTGTTAGCACAGACCTATCCGTTATCAGAAATTTATATTGTTGATGATGGGAGTTCAAACAC
AGATGCAATACAATTAATTGAAGAGTATGTAAATAGAGAAGTGGATATTTGTCGAAACGTTATCGTTCACCGTTCCCTTG
TCAATAAAGGAAAACGCCATGCTCAAGCGTGGGCATTTGAAAGATCTGACGCTGACGTTTTTTTAACCGTAGATTCAGAT
ACTTATATCTATCCAAATGCCTTAGAAGAACTCCTAAAAAGCTTCAATGATGAGACAGTTTATGCTGCAACAGGACATTT
GAATGCTAGAAACAGACAAACTAATCTATTAACGCGACTTACAGATATCCGTTACGATAATGCCTTTGGGGTGGAGCGTG
CTGCTCAATCATTAACAGGTAATATTTTAGTTTGCTCAGGACCATTGAGTATTTATCGACGTGAAGTGATTATTCCTAAC
TTAGAGCGCTATAAAAATCAAACATTCCTAGGTTTACCTGTTAGCATTGGGGATGATCGATGTTTAACAAATTATGCTAT
TGATTTAGGACGCACTGTCTACCAATCAACAGCTAGATGTGATACTGATGTACCTTTCCAATTAAAAAGTTATTTAAAGC
AACAAAATCGATGGAATAAATCTTTTTTTAGAGAATCTATTATTTCTGTCAAAAAAATTCTTTCTAATCCCATCGTTGCC
TTATGGACTATTTTCGAAGTCGTTATGTTTATGATGTTGATTGTCGCAATTGGGAATCTTTTGTTTAATCAAGCTATTCA
ATTAGACCTTATTAAACTTTTTGCCTTTTTATCCATCATCTTTATCGTTGCTTTATGTCGTAATGTTCATTATATGGTCA
AACATCCTGCTAGTTTTTTGTTATCTCCTCTGTATGGAATATTACACTTGTTTGTCTTACAGCCCCTAAAACTTTATTCT
TTATGCACCATTAAAAATACGGAATGGGGAACACGTAAAAAGGTCACTATTTTTAAATAA

Upstream 100 bases:

>100_bases
ATTAAAAATATCTCTATGTCTAGTTGACATTATTTCTTATTTATATTAGAATATTGAGGCCCTTACTTTCAAGGAAATTA
AAAAAGAAAGAGGTGTAATT

Downstream 100 bases:

>100_bases
TATATGCATCGAGTAGTTAGAGAAGGAGTAATTTTATGAAAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTA
GGAGTTCTTTTATCACTTCA

Product: hyaluronan synthase

Products: NA

Alternate protein names: Hyaluronate synthase; Hyaluronic acid synthase; HA synthase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGNPHDYKVAAVIPSYNEDAESL
LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD
TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVA
LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYS
LCTIKNTEWGTRKKVTIFK

Sequences:

>Translated_419_residues
MPIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGNPHDYKVAAVIPSYNEDAESL
LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD
TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVA
LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYS
LCTIKNTEWGTRKKVTIFK
>Mature_418_residues
PIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGNPHDYKVAAVIPSYNEDAESLL
ETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDT
YIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNL
ERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVAL
WTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSL
CTIKNTEWGTRKKVTIFK

Specific function: Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nodC/HAS family [H]

Homologues:

Organism=Homo sapiens, GI4885391, Length=436, Percent_Identity=27.9816513761468, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI20302153, Length=437, Percent_Identity=28.3752860411899, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI167466171, Length=452, Percent_Identity=27.4336283185841, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1787259, Length=269, Percent_Identity=23.4200743494424, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: =2.4.1.212 [H]

Molecular weight: Translated: 47842; Mature: 47711

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH
VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE
YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK
HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
SFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
HHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEC
>Mature Secondary Structure 
PIFKKTLIVLSFICLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH
VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE
YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK
HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
SFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVALCRNVHYMVKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
HHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]