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The map label for this gene is mutY [H]

Identifier: 21911120

GI number: 21911120

Start: 1584077

End: 1585231

Strand: Direct

Name: mutY [H]

Synonym: SpyM3_1584

Alternate gene names: 21911120

Gene position: 1584077-1585231 (Clockwise)

Preceding gene: 21911115

Following gene: 21911121

Centisome position: 83.35

GC content: 38.35

Gene sequence:

>1155_bases
ATGATTGAATTAAAAGATTATGGTATTAATATGTGGGATAATGAGACAATCGCTTCTTTTCGTCGCACACTTTTAGGGTG
GTATGACCAAGAAAAACGTGATCTCCCTTGGCGAAGAACTACTAATCCATACTATATTTGGGTTTCTGAAATCATGTTGC
AACAAACACAAGTTAATACGGTAATCCCTTATTATAAACGTTTTCTAGAGTGGTTTCCTCAAATAAAAGATTTGGCAGAC
GCTCCTGAAGAACAATTACTAAAGGCATGGGAGGGACTAGGCTATTATTCTCGGGTGCGTAATATGCAAAAGGCTGCACA
GCAAGTGATGGTTGATTTTGGTGGCATATTTCCTCACACTTATGATGATATTGCTTCATTAAAAGGGATTGGTCCTTATA
CTGCAGGTGCTATCGCCAGCATCTCATTCAACTTACCAGAGCCTGCTGTTGATGGCAATGTGATGCGTGTCATGGCTCGT
TTGTTTGAAGTTAATTATGATATCGGTGACCCTAAAAATCGTAAAATTTTTCAAGCTATTATGGAAATACTAATTGACCC
TGACAGACCCGGTGATTTTAACCAGGCACTTATGGATCTAGGTACAGACATCGAATCCGCTAAGACACCTAGGCCTGATG
AAAGCCCTATTCGTTTCTTTAACGCTGCTTATTTGAATGGTACTTATGGTAAATACCCTATAAAAAATCCAAAGAAAAAG
CCTAAACCAATGCGAATTCAGGCTTTTGTCATTCGTAACCAAAATGGCCAATATCTACTGGAGAAAAATACTAAAGGGAG
ACTTCTAGGAGGTTTTTGGTCATTTCCTATTATCGAAACGTCACCTCTTTCTCAACAATTAGATTTATTTGATGACAATC
AATCCAACCCCATAATCTGGCAAACCCAAAATGAAACTTTCGAAAGAGAATATCAATTAAAGCCCCAATGGACTGATAAT
CACTTTCCAAATATTAAGCACACTTTTAGTCACCAGAAGTGGACAATAGAACTCATAGAGGGGGTGGTCAAAGCAACAGA
TTTACCTAATGCTCCTCACCTAAAGTGGGTAGCAATTGAGGACTTTTCTCTTTATCCCTTTGCAACGCCCCAAAAGAAAA
TGCTAGAGACCTACTTAAAACAGAAAAATGCTTAA

Upstream 100 bases:

>100_bases
TGAGGTAAACCTAATATTATTATAATATTTCCTTTTCTTTTTCGCAAATACCTAAAATCTTTTTTTACTCTTTTTAAGAC
TCCTGTGTTACAATAACAAC

Downstream 100 bases:

>100_bases
TCACAAGTGAACTATGACGGTTCACTTTTTGTTTACAATTCCTTTACGCCGCTGTAAAGTTTTCCTCAGATTGTCTTTTA
ATACCTTATAAATAGTGATC

Product: putative A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MIELKDYGINMWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLAD
APEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMAR
LFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKK
PKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDN
HFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA

Sequences:

>Translated_384_residues
MIELKDYGINMWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLAD
APEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMAR
LFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKK
PKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDN
HFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA
>Mature_384_residues
MIELKDYGINMWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLAD
APEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMAR
LFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKK
PKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDN
HFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI190358497, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298648, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298650, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298654, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298652, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1789331, Length=260, Percent_Identity=40.7692307692308, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 44779; Mature: 44779

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKDYGINMWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNT
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEHHHHHHHHHHHHH
VIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
YDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAI
HHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKK
HHHHCCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCC
PKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIW
CCCEEEEEEEEECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCCCCCCCCEEE
QTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIE
ECCCCCHHHHEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEE
DFSLYPFATPQKKMLETYLKQKNA
CCEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIELKDYGINMWDNETIASFRRTLLGWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNT
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEHHHHHHHHHHHHH
VIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
YDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAI
HHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKK
HHHHCCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCC
PKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIW
CCCEEEEEEEEECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCCCCCCCCEEE
QTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIE
ECCCCCHHHHEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEE
DFSLYPFATPQKKMLETYLKQKNA
CCEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]