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The map label for this gene is typA [H]

Identifier: 21910714

GI number: 21910714

Start: 1204951

End: 1206657

Strand: Reverse

Name: typA [H]

Synonym: SpyM3_1178

Alternate gene names: 21910714

Gene position: 1206657-1204951 (Counterclockwise)

Preceding gene: 21910715

Following gene: 21910713

Centisome position: 63.49

GC content: 41.77

Gene sequence:

>1707_bases
ATGGATTCCAATGACCTTGAAAAAGAACGTGGGATTACAATCCTTGCGAAAAATACGGCAGTAGCCTATAACGATGTTCG
TATTAACATCATGGATACCCCAGGACACGCGGACTTCGGTGGTGAAGTTGAACGTATCATGAAAATGGTTGACGGGGTTG
TTCTTGTTGTGGATGCCTACGAAGGAACAATGCCCCAGACGCGTTTCGTATTGAAAAAAGCACTTGAGCAAAACCTTATC
CCAATCGTTGTGGTGAACAAGATTGACAAACCTTCAGCTCGTCCAGCAGAAGTTGTAGATGAAGTGCTTGAATTATTCAT
CGAACTTGGTGCCGATGATGAGCAATTGGAATTCCCAGTTGTTTACGCATCAGCTATTAATGGAACATCATCATTATCAG
ATGACCCTGCTGACCAAGAGCATACTATGGCACCGATCTTTGATACGATTATTGATCATATTCCAGCGCCAGTTGATAAT
TCAGATGAGCCTTTGCAATTCCAAGTGTCACTTTTGGACTACAACGATTTCGTAGGTCGTATCGGTATCGGTCGTGTTTT
CCGTGGTACTGTTAAAGTGGGTGACCAAGTAACTCTTTCAAAACTTGATGGTACCACTAAAAACTTCCGTGTTACAAAAC
TGTTTGGTTTCTTCGGTTTGGAACGTCGTGAAATTCAAGAAGCTAAAGCAGGTGACTTGATTGCTGTTTCAGGTATGGAA
GATATCTTTGTTGGAGAAACCATTACACCAACTGACTGTGTGGAAGCTCTGCCAATTCTTCGTATTGATGAGCCAACACT
TCAGATGACTTTCTTGGTCAATAACTCTCCTTTTGCAGGTCGTGAAGGTAAATGGATCACGTCACGTAAGGTTGAAGAAC
GTCTTTTAGCAGAATTGCAAACAGACGTGTCACTTCGTGTTGACCCAACAGATTCGCCAGATAAATGGACGGTTTCAGGG
CGTGGAGAATTGCACTTGTCAATTCTTATCGAAACCATGCGCCGTGAAGGCTATGAACTTCAAGTATCACGTCCAGAAGT
TATCATCAAAGAAATTGATGGTGTCAAATGTGAACCGTTTGAGCGTGTTCAAATTGATACACCAGAAGAATATCAGGGTG
CAATCATCCAGTCTCTTTCAGAACGTAAAGGGGATATGCTTGATATGCAGATGGTTGGTAATGGTCAAACGCGTTTGATT
TTCTTGATTCCTGCACGTGGTTTGATTGGTTATTCAACAGAGTTTCTTTCAATGACACGTGGATATGGTATCATGAATCA
TACTTTTGATCAGTATCTACCGGTTGTTCAAGGAGAAATTGGTGGCCGTCATCGTGGTGCCTTGGTTTCTATTGAAAATG
GGAAAGCAACGACATATTCAATCATGCGTATTGAAGAACGTGGAACTATCTTTGTCAACCCAGGTACAGAAGTTTACGAA
GGGATGATTGTTGGTGAAAACTCACGTGATAACGACCTTGGTGTTAACATTACAACAGCTAAGCAAATGACAAATGTCCG
TTCAGCGACTAAAGATCAAACTGCAGTTATCAAGACGCCTCGTATCCTAACGCTTGAAGAATCATTAGAGTTCTTGAATG
ACGACGAATACATGGAAGTAACGCCAGAATCTATCCGCTTGCGTAAGCAAATCTTGAATAAAGCTGCGCGTGATAAAGCT
AATAAAAAGAAAAAATCAGCCGAATAG

Upstream 100 bases:

>100_bases
GATTATTGCCCACGTTGACCACGGAAAAACAACACTTGTAGATGAATTATTAAAACAATCCCATACTCTTGATGAGCGTA
AAGAGCTCCAAGAGCGTGCC

Downstream 100 bases:

>100_bases
CTTTTGAAGTTAAACTAACTAAATAAAATAGCAAAAAGATATTTAAGAAAAGTCATTTTTTAAAGGTCTTTTTGCGTTTA
CAAGTTCCTATGGAATATAA

Product: putative GTP-binding protein TypA/BipA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLI
PIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDN
SDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGME
DIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSLRVDPTDSPDKWTVSG
RGELHLSILIETMRREGYELQVSRPEVIIKEIDGVKCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLI
FLIPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMRIEERGTIFVNPGTEVYE
GMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAARDKA
NKKKKSAE

Sequences:

>Translated_568_residues
MDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLI
PIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDN
SDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGME
DIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSLRVDPTDSPDKWTVSG
RGELHLSILIETMRREGYELQVSRPEVIIKEIDGVKCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLI
FLIPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMRIEERGTIFVNPGTEVYE
GMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAARDKA
NKKKKSAE
>Mature_568_residues
MDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLI
PIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDN
SDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGME
DIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSLRVDPTDSPDKWTVSG
RGELHLSILIETMRREGYELQVSRPEVIIKEIDGVKCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLI
FLIPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMRIEERGTIFVNPGTEVYE
GMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAARDKA
NKKKKSAE

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=471, Percent_Identity=24.8407643312102, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI94966754, Length=94, Percent_Identity=42.5531914893617, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI18390331, Length=102, Percent_Identity=42.156862745098, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI25306283, Length=122, Percent_Identity=37.7049180327869, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI19923640, Length=122, Percent_Identity=37.7049180327869, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI25306287, Length=122, Percent_Identity=37.7049180327869, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34147630, Length=239, Percent_Identity=30.9623430962343, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI94966752, Length=81, Percent_Identity=43.2098765432099, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217272892, Length=89, Percent_Identity=41.5730337078652, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI217272894, Length=89, Percent_Identity=41.5730337078652, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI48994988, Length=565, Percent_Identity=54.5132743362832, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=471, Percent_Identity=27.3885350318471, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789738, Length=127, Percent_Identity=39.3700787401575, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790835, Length=134, Percent_Identity=29.8507462686567, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=476, Percent_Identity=25.4201680672269, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=400, Percent_Identity=24.75, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17533571, Length=137, Percent_Identity=37.956204379562, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17552882, Length=90, Percent_Identity=35.5555555555556, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988811, Length=90, Percent_Identity=35.5555555555556, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988819, Length=90, Percent_Identity=35.5555555555556, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=263, Percent_Identity=28.1368821292776, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17506493, Length=68, Percent_Identity=39.7058823529412, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=469, Percent_Identity=27.9317697228145, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323098, Length=136, Percent_Identity=33.8235294117647, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324761, Length=235, Percent_Identity=29.7872340425532, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324707, Length=107, Percent_Identity=38.3177570093458, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320593, Length=107, Percent_Identity=38.3177570093458, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI78706572, Length=478, Percent_Identity=24.2677824267782, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24582462, Length=158, Percent_Identity=34.1772151898734, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363316, Length=265, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17864358, Length=265, Percent_Identity=30.188679245283, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357743, Length=143, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574573, Length=99, Percent_Identity=38.3838383838384, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221458488, Length=114, Percent_Identity=40.3508771929825, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 63369; Mature: 63369

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAY
CCCCCCHHHCCEEEEEECCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECC
EGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQLEFPV
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
VYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGR
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHCC
IGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGME
CCCCCEEECEEECCCEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHCCCCCEEEECCCC
DIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQ
CEEECCCCCHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHH
TDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGVKCEPF
CCCEEEECCCCCCCEEEECCCCCEEHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCC
ERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPARGLIGYSTEFLSMTR
CEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHC
GYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMRIEERGTIFVNPGTEVYE
CCCCHHCCHHHHHCHHCCCCCCCCCCEEEEEECCCEEEEEEEEEECCCEEEECCCHHHHC
GMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEV
CEEEECCCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEECCEEEEHHHHHHHHCCCCEEEE
TPESIRLRKQILNKAARDKANKKKKSAE
CHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDSNDLEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAY
CCCCCCHHHCCEEEEEECCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECC
EGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLELFIELGADDEQLEFPV
CCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
VYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGR
EEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHCC
IGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGME
CCCCCEEECEEECCCEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHCCCCCEEEECCCC
DIFVGETITPTDCVEALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQ
CEEECCCCCHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHH
TDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGVKCEPF
CCCEEEECCCCCCCEEEECCCCCEEHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCC
ERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPARGLIGYSTEFLSMTR
CEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHC
GYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGKATTYSIMRIEERGTIFVNPGTEVYE
CCCCHHCCHHHHHCHHCCCCCCCCCCEEEEEECCCEEEEEEEEEECCCEEEECCCHHHHC
GMIVGENSRDNDLGVNITTAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEV
CEEEECCCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEECCEEEEHHHHHHHHCCCCEEEE
TPESIRLRKQILNKAARDKANKKKKSAE
CHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]