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The map label for this gene is pyrP [H]

Identifier: 21910095

GI number: 21910095

Start: 612165

End: 613379

Strand: Direct

Name: pyrP [H]

Synonym: SpyM3_0559

Alternate gene names: 21910095

Gene position: 612165-613379 (Clockwise)

Preceding gene: 21910094

Following gene: 21910096

Centisome position: 32.21

GC content: 38.77

Gene sequence:

>1215_bases
ATGTTAGTTGGTTTGTCCTTTCAGCATTTATTTGCCATGTTTGGGGCGACGGTTCTTGTTCCTATTTTAGTTGGAATTGA
CCCGTCTGTGGCCCTCCTATCGAGTGGTTTAGGAACACTTGCACATTTATCGGTAACCAAATTTAAAATTCCAGCCTACA
TGGGCTCAAGTTTTGCTTATATAGCAGCTATGCAGTTACTGATGAAGACAAATGGTATTGGTGCTGTAGCTCAAGGGGCT
ATGACAGGAGGTCTCGTTTACCTGATTGTAGCTTTGATTGTTAAAGTTATTGGCAATGATTGGATTGATAAGATTTTACC
ACCGATTGTAGTTGGTCCGATTGTTATGGTCATTGGTCTAAGTCTAGCTTCTACAGCTGTTAATGATGTCATGTTAAAAA
ATGGGAACTATAATCTGACTTATCTTGTTATTGGGTTAGTCACCTTATTATCAGTTATTTTTTTCAATATTTATGGTAAG
GGAATTGTTGCTATTGTACCGCTTTTATTAGGGCTATTAGTTGGTTATGTTGTAGCCCTTTTAGTGGGTGTTCTCACCGG
TCAAGAAATTGTTGATTTTACCAATGTGGCTCAGGCCAAATGGTTTAGTATCCCATCAGTGGAAATTCCTTTCTTAACCT
ACGGGGTTAAATTCTACCCAAGTGCCATTTTAACTATGGCACCCATTGCCTTTGTTACAATGACAGAACATTTTGGACAC
ATTATGGTCTTAAATAGTTTGACAAAAAGAGATTATTTCAAGGATCCAGGACTTGAAAAGACTTTAACTGGTGATGGTTT
TGCGCAAATCATTGCCGGCTTCTTAGGGGCACCTCCGGTCACTTCTTATGGTGAAAACATCGGTGTAATGGCTTTGAATA
AAATATTCTCGGTCTATGTTATTGCAGGTGCCGCAGTGATTGCCGCTCTCCTCAGTTTTATCGGTAAGGTATCAGCCTTA
ATTCAATCTATTCCAACACCAGTTATTGGAGGTATATCAGTTGCCTTGTTTGGTGTGATAGCTTCTAGCGGTTTGAAAAT
CTTGATTGAATCCAAAGTTGATATGGATAATAAGAAAAACTTATTGATTGCCAGTGTCATTTTGGTCTCTGGGATTGGAG
GATTGATGCTTCAAGTAAATGGTCTTCAAATTTCAGGTGTCGCTTTCTCAACACTTCTTGGCATCATCTTATATCAGGTA
CTTCCTGAAAAATAG

Upstream 100 bases:

>100_bases
TGATGGCCGTGATCGTGTTAGCATTATTGACCCAACATAAGAAGGAGGTTTTACTGTGAAAGATGTCATTTATGATGTGG
AAGAAGTGCCAAAGGCAGGT

Downstream 100 bases:

>100_bases
GAAGAATTGTTGTTAGACCACTTACATAGTCATCAGTCGTTAGTGATAAAGGGGATAATCATGTCAGTTGTAAATAATCG
CGTTGCACTTACCAATTTAG

Product: putative uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGA
MTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGK
GIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILTMAPIAFVTMTEHFGH
IMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSAL
IQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQV
LPEK

Sequences:

>Translated_404_residues
MLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGA
MTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGK
GIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILTMAPIAFVTMTEHFGH
IMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSAL
IQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQV
LPEK
>Mature_404_residues
MLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGA
MTGGLVYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGK
GIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILTMAPIAFVTMTEHFGH
IMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSAL
IQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQV
LPEK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=420, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI44680143, Length=427, Percent_Identity=24.5901639344262, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788843, Length=394, Percent_Identity=42.8934010152284, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87081818, Length=410, Percent_Identity=38.2926829268293, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082181, Length=389, Percent_Identity=25.4498714652956, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082178, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790087, Length=441, Percent_Identity=23.5827664399093, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356175, Length=291, Percent_Identity=26.8041237113402, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42406; Mature: 42406

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]