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The map label for this gene is cap3A [H]

Identifier: 21909921

GI number: 21909921

Start: 429671

End: 430828

Strand: Direct

Name: cap3A [H]

Synonym: SpyM3_0385

Alternate gene names: 21909921

Gene position: 429671-430828 (Clockwise)

Preceding gene: 21909920

Following gene: 21909922

Centisome position: 22.61

GC content: 30.22

Gene sequence:

>1158_bases
ATGAAAATTACAGTTGTAGGCATTGGATACGTTGGATTATCGATAGGGCTCCTACTTGCAAAGGAACACGACGTTACCTT
TTTTGATATTGATAATAAAAAAATTGATTTAATAAATAAAAGGCAATCCCCTCTTAAAGAAGCAGCTATAAACAAACTTT
TATGTAAGGCAAAAAATATTAATGCAACTTATTCTGAAGAATTAGCATATAAGGATGCGACTTTCATAATCTTGTCTTTG
CCAACCAACCTAAAAGTTAATAAGCTTGATACTTCCATTATCGAAATTTCTGTAAGTAATATTTTAAAGATAAACAAAAA
GGCTACAATTGTAATAAAGTCGACAGTTCCAATTGGTTTTACAGAATATTTAAGGAATCGATTTCACTACAACGATATCA
TTTTTTCACCTGAGTTCCTTAGGGAAGGATCAACTATTTATGATCAATTGTATCCTTCGAGAACTATAGTTGGAAATGAA
TCTAGAAATTCTCAATTATTCTTAGACATACTAACAGATATATCGGTTGAAAAAGACTCGTCATCTTTATTAGTTGGCTC
TTCTGAAGCAGAAGCGATAAAGTTATTTTCGAATGCATACTTGGCACAAAAAATTGCTTTTTTTAATGAGTTGGATACGT
TTGCTGAAATGCAAAATTTGGACTCAAAAAAAATTATTGAGGCTATGGGATATGACCAGAGAATAGGAAATTCGCACAAT
AATCCTTCTTTCGGTTTTGGTGGGTACTGTCTTCCTAAGGATATTAAGCAATTAGAGTATCATTTTAAAGAAATTCCAGC
ACCAATTATTACCAGTATAAGTGAGTCTAATTTATTAAGAAAAATTCATATAGCAAAAATGATTTTGAACAGCTCAGCTA
AAACAATAGGAATTTATAGAATTAATTCCAAAAAAGATTCGGATAATTGTAGGGAATCTTCTACAATTGATGTTGCTAAA
CTTCTAAAAAGCAGTGGTAAGGATGTTATCATCTTTGAGCCCTTAATTAACCAAAAAAAGTTTTTGGGGTGCCCTTTAAT
TAATGATTTTAATGAATTTATTAAATATTCGGATATTATAGTTGCCAATAGAATAGATGATGCTCTGAGAAAATGTAATT
CAAAAGTTTTTACACGTGATATTTTTCAGTATGATTAA

Upstream 100 bases:

>100_bases
ATCCAAAAATTTATATCATCTCATTTAGGTATAAAAATCAATTTTATATTCTTTCTAACAAAAAAATTGATTTATAAAAA
GTTTTAGAATAGAGGTTAAC

Downstream 100 bases:

>100_bases
CAAAAACATTTTTGCGAAAAAATATTTTTAAGTAATAAATTCAGTTAAAAGTTATTATATCTGAAAATTTTAAAGGTCTT
TAAAATGAACAATAGGAAAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATYSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIYDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSSSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Sequences:

>Translated_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATYSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIYDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSSSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD
>Mature_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATYSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIYDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSSSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Specific function: Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis. Directly responsible for the transformation of some unencapsulated serotype-3 SP mutants to the encapsulated phenotype [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=373, Percent_Identity=28.686327077748, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI296040438, Length=274, Percent_Identity=29.9270072992701, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI296040443, Length=359, Percent_Identity=25.0696378830084, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=43.5567010309278, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=22.7160493827161, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=375, Percent_Identity=28, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17136908, Length=414, Percent_Identity=29.2270531400966, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43489; Mature: 43489

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
NATYSEELAYKDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCHHHHHHCCCEEEEEEECCCCCEEECCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIYDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEEEHHCCCCCCCC
SSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
NATYSEELAYKDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCHHHHHHCCCEEEEEEECCCCCEEECCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIYDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEEEHHCCCCCCCC
SSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929009; 8566758; 7869055 [H]