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The map label for this gene is msrA.2 [H]

Identifier: 21909865

GI number: 21909865

Start: 369550

End: 370059

Strand: Direct

Name: msrA.2 [H]

Synonym: SpyM3_0329

Alternate gene names: 21909865

Gene position: 369550-370059 (Clockwise)

Preceding gene: 21909864

Following gene: 21909866

Centisome position: 19.44

GC content: 42.16

Gene sequence:

>510_bases
ATGGAAAGAGCCATTTTTGCAGGAGGTTGTTTCTGGTGTATGGTGCAACCTTTTGAGGAGCAAGCAGGTATTTTGTCAGT
CAGAAGTGGCTACACAGGTGGGCATCTCCCAAATCCTAGCTATGAACAAGTTTGTGCCAAAACAACAGGACATACAGAAG
CTGTTGAAATTATTTTTGACCCTGAAGAGATCAGCTATAAGGAATTAGTTGAATTGTATTGGGTGCAGACGGATCCAACA
GACGCCTTTGGGCAATTTGAAGATCGTGGGGACAACTACCGTCCTGTCATTTACTATACAACGGAAAGACAAAAAGAAAT
TGCAGAGCAATCAAAAGCAAACTTGCAAGCTTCAGGACGTTTTGACCAACCCATTGTCACCACTATTGAACCAGCAGAGC
CATTTTATCTCGCAGAGGATTATCACCAAGGATTTTATAAAAAGAATCCCAAGCGGTATGCACAAAGCAGTGCTATTCGT
CATCAGTTTTTAGAGGAGAATTGGTCATGA

Upstream 100 bases:

>100_bases
CGCCACAGGAACTGAATTAATAGGATAAAAATGCTTTGCCACTGGCAAAGTTTTTTGTTACAATGAAGACCATTAACTGA
AGAAAAAGGGGATATAGAGA

Downstream 100 bases:

>100_bases
GAAAATCATTTTACAGCTGGCTGATGACACAACGTAACCCTAAATCAAATGAACCTGTGGCGATTTTAGCAGATTTGGTG
TTTGATGACACCACTTTTCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWVQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS

Sequences:

>Translated_169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWVQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS
>Mature_169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWVQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=40.6451612903226, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=40.6451612903226, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=42.9906542056075, Blast_Score=90, Evalue=8e-19,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=45.0980392156863, Blast_Score=134, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=35.7615894039735, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=29.2993630573248, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=33.9393939393939, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=33.75, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19512; Mature: 19512

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFD
CCCEEECCCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEC
PEEISYKELVELYWVQTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGR
CCCCCHHHHHHHHEECCCCCCHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCC
FDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CCCCEEEEECCCCCEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFD
CCCEEECCCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEC
PEEISYKELVELYWVQTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGR
CCCCCHHHHHHHHEECCCCCCHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCC
FDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CCCCEEEEECCCCCEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]