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The map label for this gene is murC [H]

Identifier: 21909788

GI number: 21909788

Start: 294160

End: 295488

Strand: Direct

Name: murC [H]

Synonym: SpyM3_0252

Alternate gene names: 21909788

Gene position: 294160-295488 (Clockwise)

Preceding gene: 21909787

Following gene: 21909789

Centisome position: 15.48

GC content: 37.62

Gene sequence:

>1329_bases
ATGTCAAAAACGTATCATTTTATCGGAATTAAAGGGTCAGGAATGAGTGCCTTGGCCCTTATGTTGCATCAAATGGGGCA
TAAGGTGCAAGGTAGTGATGTTGAAAAATACTATTTCACTCAAAGAGGATTGGAACAAGCGGGCATCACTATCTTACCTT
TTAGCGAGGACAACATTACGCCAGATATGGAACTTATCGTTGGGAATGCCTTTCGTGAAAACAACAAAGAAGTGGCCTAT
GCTTTGAGACACCAGATTCCTTTCAAACGTTATCATGACTTTTTAGGTGATTTTATGAAATCATTTATCAGTTTTGCAGT
AGCAGGTGCTCATGGTAAAACTTCTACAACGGGTTTATTGTCACATGTCTTGAAAAATATCACAGACACATCTTATTTAA
TTGGTGATGGTACTGGGCGTGGGTCTGCTAATGCGCAGTATTTTGTTTTTGAATCAGACGAATACGAACGCCATTTTATG
CCTTATCACCCAGAATACTCTATCATTACTAATATTGATTTTGACCATCCTGATTATTTCACAGGAATTGCTGATGTGCG
AAACGCTTTCAACGATTATGCTAAGCAGGTCAAGAAAGCTTTGTTTGTTTATGGTGAAGATGACGAACTAAAAAAGATCG
AAGCACCTGCACCTATTTACTATTATGGTTTTGAAGAGGGCAATGATTTTATCGCTTACGACATTACGCGTACTACGAAC
GGATCGGACTTTAAGGTAAAACACCAAGGAGAGGTCATTGGTCAGTTTCACGTACCTGCTTATGGAAAACATAACATTTT
AAACGCTACAGCAGTAATTGCAAACTTGTTTGTAGCCGGCATTGATATGGCTCTAGTGGCAGACCATCTTAAAACTTTTT
CAGGTGTGAAACGTCGTTTTACAGAGAAAATTATCAATGACACTATTATTATTGATGACTTTGCTCATCATCCAACCGAA
ATTGTGGCAACAATTGATGCGGCTAGACAAAAATACCCAAGTAAAGAAATTGTAGCAATATTCCAGCCACATACTTTTAC
TCGCACTATTGCCTTATTAGAGGATTTTGCTTGTGCTTTAAATGAAGCTGACAGTGTTTATTTAGCCCAGATTTATGGTT
CTGCACGTGAAGTAGATAAAGGTGAAGTTAGGGTTGAAGATTTGGCTGCTAAGATTATCAAACCATCACAAGTAGTAACG
GTGGAAAATGTCTCTCCTCTTCTTGATCACGATAATGCTGTTTATGTTTTTATGGGAGCTGGAGATATTCAGCTATATGA
ACATTCTTTTGAGGAATTACTTGCAAATTTAACTAAAAATAACCAATAA

Upstream 100 bases:

>100_bases
ACAACGAGAAAAAACAATTGCGCAAGAGCTTAATCTTAGTAGGTTTGAGGATCTTCCTTAATAAATCTACTCAGCGTATG
CAGATGACAAAGGAGTTAAG

Downstream 100 bases:

>100_bases
CATGTCCTGCCTTAGGCAGGTTTTCTCATTCTAAAGGAGTTTGATATGTTGATTAGACAGGTTCAAGGATCCGATTTGGA
AGTTATTGCTACCATTGAAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAY
ALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFM
PYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTE
IVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVT
VENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ

Sequences:

>Translated_442_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAY
ALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFM
PYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTE
IVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVT
VENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
>Mature_441_residues
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYA
LRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMP
YHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTNG
SDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEI
VATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVTV
ENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1790680, Length=425, Percent_Identity=30.3529411764706, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1786279, Length=459, Percent_Identity=27.8867102396514, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49622; Mature: 49491

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNIT
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCEEEEECCCCCCC
PDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLL
CCHHEEEECHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
SHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYF
HHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHH
TGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
HHHHHHHHHHHHHHHHHHHHEEEECCCCCHHEECCCCCEEEEEECCCCEEEEEEEEECCC
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRF
CCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACAL
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGA
CCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECC
GDIQLYEHSFEELLANLTKNNQ
CCEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNIT
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCEEEEECCCCCCC
PDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLL
CCHHEEEECHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
SHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYF
HHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHH
TGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
HHHHHHHHHHHHHHHHHHHHEEEECCCCCHHEECCCCCEEEEEECCCCEEEEEEEEECCC
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRF
CCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACAL
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NEADSVYLAQIYGSAREVDKGEVRVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGA
CCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECC
GDIQLYEHSFEELLANLTKNNQ
CCEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]