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The map label for this gene is purM [H]

Identifier: 21909558

GI number: 21909558

Start: 42314

End: 43336

Strand: Direct

Name: purM [H]

Synonym: SpyM3_0022

Alternate gene names: 21909558

Gene position: 42314-43336 (Clockwise)

Preceding gene: 21909557

Following gene: 21909559

Centisome position: 2.23

GC content: 42.82

Gene sequence:

>1023_bases
ATGTCTGAAAAAAATGCTTATGCAAAATCTGGTGTTGATGTTGAAGCTGGTTATGAAGTGGTTGAAAGAATAAAAAAACA
CGTTGCTCGTACAGAACGTGCGGGAGTCATGGGAGTTCTAGGTGGCTTTGGTGGGATGTTTGACTTGAGTAAAACAGGAG
TTAAAGAGCCTGTCTTGGTTTCAGGGACTGACGGTGTCGGAACAAAACTGATGCTTGCTATCAAGTACGACAAGCACGAC
ACAATCGGTCAAGACTGTGTTGCCATGTGTGTCAACGATATTATTGCAGCAGGTGCTGAGCCATTATATTTTTTAGATTA
TATTGCGACAGGAAAAAATAATCCAGTCAAACTTGAAGAAGTTGTTTCTGGCGTTGCAGAAGGTTGTGTTCAAGCAGGAG
TAGCACTCATTGGAGGTGAAACCGCTGAAATGCCTGGGATGTATGGCGAAGATGATTATGACCTTGCTGGCTTTGCTGTT
GGTGTGGCTGAAAAATCTCAAATCATCGACGGTTCAAAAGTAAAAGAAGGCGATATTCTTTTGGGACTTGCTTCAAGTGG
TATCCATTCAAACGGTTATTCTTTGGTACGTCGTGTCTTTGCTGACTATACTGGTAAAGAGTTGCTTCCAGAGCTTGAAG
GCAAACAACTTAAGGATGTCCTTCTTGAGCCAACTCGTATCTATGTTAAAGCAGCTCTGCCATTAATCAAGGAAGAACTA
GTCAACGGTATCGGCCACATCACGGGTGGTGGCTTTATCGAGAATGTTCCTCGTATGTTTGCGGATGATTTGGCTGCGGA
AATCGATGAGGACAAGGTGCCAGTGCTTCCGATTTTCAAGGCGCTTGAAAAATATGGTGACATCAAGCACGAAGAAATGT
TTGAAATCTTCAATATGGGTGTCGGTCTTATGCTAGCTGTTAGTCCTGAAAATGTTAACCGCGTCAAAGAGCTCTTGGAT
GAACCAGTTTATGAAATCGGTCGTATCATCAAGAAAGCAGACGCTAGTGTGGTGATTAAATAA

Upstream 100 bases:

>100_bases
TTATGATTATGAAGAAGAATACCTCAGAAGTTTAGAAGAGAAAACAAGTTTTTATATTCAAAAAGTGAAATAAGCTCTGC
TAATTATATAAGGAGAAAAC

Downstream 100 bases:

>100_bases
GTCACTAAATTTTATAAGAAAGGAGTGTTTAGTTAGTTTGCCTAACTGAACACGGGATTAAATTTCTAGGAAAAAAGATA
AAACGACTTAGACGCAAGCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFGGMFDLSKTGVKEPVLVSGTDGVGTKLMLAIKYDKHD
TIGQDCVAMCVNDIIAAGAEPLYFLDYIATGKNNPVKLEEVVSGVAEGCVQAGVALIGGETAEMPGMYGEDDYDLAGFAV
GVAEKSQIIDGSKVKEGDILLGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEEL
VNGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMGVGLMLAVSPENVNRVKELLD
EPVYEIGRIIKKADASVVIK

Sequences:

>Translated_340_residues
MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFGGMFDLSKTGVKEPVLVSGTDGVGTKLMLAIKYDKHD
TIGQDCVAMCVNDIIAAGAEPLYFLDYIATGKNNPVKLEEVVSGVAEGCVQAGVALIGGETAEMPGMYGEDDYDLAGFAV
GVAEKSQIIDGSKVKEGDILLGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEEL
VNGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMGVGLMLAVSPENVNRVKELLD
EPVYEIGRIIKKADASVVIK
>Mature_339_residues
SEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFGGMFDLSKTGVKEPVLVSGTDGVGTKLMLAIKYDKHDT
IGQDCVAMCVNDIIAAGAEPLYFLDYIATGKNNPVKLEEVVSGVAEGCVQAGVALIGGETAEMPGMYGEDDYDLAGFAVG
VAEKSQIIDGSKVKEGDILLGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEELV
NGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMGVGLMLAVSPENVNRVKELLDE
PVYEIGRIIKKADASVVIK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=46.3343108504399, Blast_Score=306, Evalue=1e-83,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=46.3343108504399, Blast_Score=306, Evalue=1e-83,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=46.3343108504399, Blast_Score=306, Evalue=1e-83,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=52.9411764705882, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=41.0714285714286, Blast_Score=234, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=46.1538461538462, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=40.8304498269896, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36501; Mature: 36369

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFGGMFDLSKTGVKEPVLV
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHCCCCCCEEE
SGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYIATGKNNPVKLEE
ECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHH
VVSGVAEGCVQAGVALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVKEGDIL
HHHHHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCHHHHEEEHHHHHHCCCCCCCCCCCEE
LGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEEL
EEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VNGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMG
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
VGLMLAVSPENVNRVKELLDEPVYEIGRIIKKADASVVIK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure 
SEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGVLGGFGGMFDLSKTGVKEPVLV
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHCCCCCCEEE
SGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYIATGKNNPVKLEE
ECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHH
VVSGVAEGCVQAGVALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVKEGDIL
HHHHHHHHHHHHCHHHCCCCHHHCCCCCCCCCCCHHHHEEEHHHHHHCCCCCCCCCCCEE
LGLASSGIHSNGYSLVRRVFADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEEL
EEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VNGIGHITGGGFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMG
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
VGLMLAVSPENVNRVKELLDEPVYEIGRIIKKADASVVIK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA