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The map label for this gene is ntpA [H]

Identifier: 161485755

GI number: 161485755

Start: 141064

End: 142839

Strand: Direct

Name: ntpA [H]

Synonym: SpyM3_0120

Alternate gene names: 161485755

Gene position: 141064-142839 (Clockwise)

Preceding gene: 21909655

Following gene: 21909657

Centisome position: 7.42

GC content: 46.62

Gene sequence:

>1776_bases
GTGAACCAAGGAAAAATAATAACCGTTTCGGGACCTCTTGTTGTGGCTTCTGGGATGCAAGAAGCTAATATTCAAGATAT
TTGTCGTGTGGGACATCTTGGCTTAGTCGGAGAAATTATTGAAATGCGCCGCGATCAAGCGTCTATTCAGGTTTATGAGG
AAACATCAGGGATCGGTCCAGGAGAACCAGTAGTGACTACTGGTTGTCCTTTGTCGGTCGAGTTAGGCCCGGGCCTGATT
TCAGAAATGTTTGACGGTATTCAGCGACCGCTTGATCGTTTTCAAAAAGCAACGGACAGCGACTTTTTAATCCGTGGTGT
GGCTATCCCAAGTCTTGATCGAAAGGCTAAGTGGGCATTTATTCCCAAGCTAAGTGTTGGTCAAGAAGTAGTTGCAGGTG
ATATTTTAGGAACTGTGCAAGAAACAGCTGTCATTGAGCATCGTATCATGGTTCCTTATAAAGTTTCAGGGACCTTGGTG
GCTATTCATGCAGGGGACTTCACAGTAACAGATACAGTTTATGAAATTAAGCAGGAAGACGGTTCCATTTACCAAGGTAG
CCTCATGCAGACTTGGCCAGTTCGTCAAAGTCGCCCTGTTGCTCAAAAGCTTATCCCAGTCGAGCCTTTGGTTACAGGTC
AACGGGTTATTGACACCTTTTTCCCTGTTACAAAAGGTGGTGCCGCTGCCGTTCCTGGACCATTTGGGGCAGGAAAAACA
GTTGTGCAGCATCAAATAGCTAAATTTGCCAACGTTGATATTGTTATTTATGTCGGTTGTGGGGAACGCGGCAACGAGAT
GACCGACGTTTTGAATGAGTTTCCAGAGTTAATTGACCCAAATACAGGCCAGTCCATTATGGAGCGCACGGTGTTAATTG
CAAACACCTCTAATATGCCAGTAGCAGCGCGTGAAGCGTCGATTTACACAGGCATTACCATTGCCGAATATTTCCGTGAT
ATGGGCTATTCTGTGGCTATCATGGCAGACTCGACATCACGTTGGGCAGAAGCTCTGCGCGAGATGTCAGGGCGCCTACA
AGAAATGCCTGGTGATGAAGGCTATCCGGCTTACTTAGGGAGTCGTATTGCCGAATATTATGAACGGGCTGGTCGTGTTC
GGACCTTGGGAAGTCAAGAACGTGAGGGAACCATTACAGCCATCGGCGCGGTTTCTCCTCCTGGAGGGGATATTTCAGAG
CCTGTCACTCAAAACACCCTTCGGATTATCAAAGTTTTCTGGGGGCTCGACGCGCCTCTTGCGCAACGGCGTCACTTCCC
AGCGATTAACTGGCTGACGTCTTATTCATTGTATCAAGATGATGTAGGAAGCTATATTGACCGTAAACAGGAATCTAATT
GGTCCAACAAGGTAACTCGTGCCATGGCTATTTTGCAGCGTGAAGCCAGTCTAGAAGAAATTGTACGCTTGGTGGGGCTT
GATTCACTGTCTGAACAAGATCGTTTGACCATGGCTGTTGCCCGGCAAATTCGGGAGGATTATCTCCAGCAAAATGCCTT
TGATTCGGTGGATACCTTTACTTCCTTTCCGAAACAAGAGGCCATGCTAACCAATATTTTGACCTTTAATGAGGAAGCCA
GCAAAGCCCTTTCTTTGGGAGCTTATTTTAATGAGATTATGGAAGGCACTGCTCAGGTACGCGATCGCATCGCACGCAGC
AAATTTATCCCAGAAGAAAACTTGGAGCAGATTAAAGGGCTTACTCAGAAGGTTACCAAAGAGATTCACCACGTTTTAGC
AAAGGGAGGAATTTAG

Upstream 100 bases:

>100_bases
GAACGCATAGGATAGTTTGCTGACTATTCAAAATAGTCACATTAAACCTTGACAGTATAGATTAGTTAGTATGATTTGGA
AAAAATAAAGGAGGAAAAAG

Downstream 100 bases:

>100_bases
ATGAGCGTTCTCAAAGAATATCGGACGGTTAGCGAAGTGGTTGGCCCTTTGATGATTGTTGATCAAGTTGCAGGAGTGCA
CTACAACGAATTGGTAGATA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIIKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQESNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI

Sequences:

>Translated_591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIIKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQESNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
>Mature_591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIIKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQESNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=562, Percent_Identity=53.3807829181495, Blast_Score=600, Evalue=1e-171,
Organism=Homo sapiens, GI32189394, Length=316, Percent_Identity=31.6455696202532, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI19913428, Length=233, Percent_Identity=29.1845493562232, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI19913426, Length=233, Percent_Identity=29.6137339055794, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI50345984, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4757810, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790170, Length=342, Percent_Identity=28.3625730994152, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788251, Length=308, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790172, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=559, Percent_Identity=52.7728085867621, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI25144756, Length=316, Percent_Identity=31.6455696202532, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17510931, Length=225, Percent_Identity=30.6666666666667, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17570191, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988080, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71988074, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988063, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320016, Length=357, Percent_Identity=46.7787114845938, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6322581, Length=360, Percent_Identity=29.7222222222222, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319603, Length=240, Percent_Identity=30.8333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319370, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583988, Length=562, Percent_Identity=52.846975088968, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583986, Length=562, Percent_Identity=52.846975088968, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583984, Length=562, Percent_Identity=52.846975088968, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583992, Length=562, Percent_Identity=52.6690391459075, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI20129479, Length=537, Percent_Identity=52.5139664804469, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI28574560, Length=320, Percent_Identity=35, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24638766, Length=317, Percent_Identity=31.8611987381703, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281361666, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646341, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17136796, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24658560, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 64983; Mature: 64983

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGP
CCCCCEEEEECCEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAF
CCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEE
IPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLVAIHAGDFTVTDTVYEIKQED
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCEEEHHHHHHHHHCC
GSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
CCEEECCCCEECCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIAEYFRDMGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLG
EEECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISEPVTQNTLRIIKVFWGLDAPL
HHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYQDDVGSYIDRKQESNWSNKVTRAMAILQREASLEEIVRLVGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCC
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
AYFNEIMEGTAQVRDRIARSKFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGP
CCCCCEEEEECCEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAF
CCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEE
IPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLVAIHAGDFTVTDTVYEIKQED
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCEEEHHHHHHHHHCC
GSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
CCEEECCCCEECCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIAEYFRDMGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLG
EEECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISEPVTQNTLRIIKVFWGLDAPL
HHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYQDDVGSYIDRKQESNWSNKVTRAMAILQREASLEEIVRLVGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCC
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
AYFNEIMEGTAQVRDRIARSKFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]