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The map label for this gene is mutY

Identifier: 21672797

GI number: 21672797

Start: 588846

End: 589889

Strand: Direct

Name: mutY

Synonym: BUsg534

Alternate gene names: 21672797

Gene position: 588846-589889 (Clockwise)

Preceding gene: 21672795

Following gene: 21672798

Centisome position: 91.8

GC content: 22.41

Gene sequence:

>1044_bases
ATGACAATATATGTTTTTTCGCAATTAATTCTTAATTGGTATCATATAAATGGAAGAAAAAATCTTCCATGGAAAAAAGA
TAAAACTTTATATAAAGTTTGGATATCAGAAATAATGTTACAGCAAACAACTGTAAAAACAGCAATTCCTTATTTTAAAA
ATTTTATATCAAGATTTCCAAATATACAATCTTTAAATCAAAGTAAATTAGACGATATTTTATGTTTATGGAGTGGACTT
GGATATTATAAAAGAGCAGAAAATATTTATAAAACAGTGAAAATTATTAAAGAAGAATTCCAAGAAAAATTTCCAACAGG
ATTTTCAGACCTAATTAAATTACCAGGAATTGGAAGATCTACAGCAGGTGCTATTTTATCGTTATCATTAGATTATTTTT
TTCCTATTTTAGAAGGAAATGTAAAAAGAATTTTAATGAGATATTACGGTATAATTGGATATGTAACAGAAAAAAAAATA
GAACAAAAATTATGGTATTTAATCGAATTAATTACTCCAATTCATAATACTGGTAGCTTTAATCAGGGTATAATGGATAT
AGGTGCATTAATTTGTACTCCTAAAAATCCAAAATGTAATTTATGCCCATTAATACAAAAATGCATAGCTTACAAAGAAA
AAAATTGGATTAAATATCCATTAAAAAAAAAGAAAAAGATAATACTAGAAAAAAAATCTTGGTTTGTTGTTATCAAATAT
CAAAATCAATTTTGGATTGAAAAAAATACAGAAAAAAAAATTTGGAAAAATTTATTTTGTTTTCCAAATTTTGATACTAA
AATTAAAACCATAGAATGGTTAAAAAAAAATAAAATCAATATAGATAAAAAACATAAAAAAATTCAATCTTTTTATCATA
AATTTAGTCATTTTACACTTCATATTATTCCAATTCTAGTAAATTTATCTTTTTTTAAAAATTTTCAGAATAGTAAAAAA
ACAGGAATTTGGTATGATTTGAAAAACACACACGACATAGGTCTTCCTAAACCAGTTCAAAAAATACTAGAAATATTTAA
ATAG

Upstream 100 bases:

>100_bases
ATACTTTTTTTAATCAAGTAAAAAATATTGAAGTCAATTACATTAAGATAATTTATATCTCATATTTTTTAAAATTTTTA
AAATTAAAAAATTCTATAAA

Downstream 100 bases:

>100_bases
TTTTTAATAAAAAAGGTTAAAAAAAATGAATCGTATAATTTTTTGTACATTTTTACAAAAAAAATCTGAAGGTCAAGATT
ATCCTCCTTATCCAGGAAAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFPNIQSLNQSKLDDILCLWSGL
GYYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRSTAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKI
EQKLWYLIELITPIHNTGSFNQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKY
QNQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTLHIIPILVNLSFFKNFQNSKK
TGIWYDLKNTHDIGLPKPVQKILEIFK

Sequences:

>Translated_347_residues
MTIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFPNIQSLNQSKLDDILCLWSGL
GYYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRSTAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKI
EQKLWYLIELITPIHNTGSFNQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKY
QNQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTLHIIPILVNLSFFKNFQNSKK
TGIWYDLKNTHDIGLPKPVQKILEIFK
>Mature_346_residues
TIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFPNIQSLNQSKLDDILCLWSGLG
YYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRSTAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKIE
QKLWYLIELITPIHNTGSFNQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKYQ
NQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTLHIIPILVNLSFFKNFQNSKKT
GIWYDLKNTHDIGLPKPVQKILEIFK

Specific function: Adenine glycosylase active on G-A and C-A mispairs

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family

Homologues:

Organism=Homo sapiens, GI115298648, Length=219, Percent_Identity=34.703196347032, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI115298654, Length=219, Percent_Identity=34.703196347032, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI115298652, Length=219, Percent_Identity=34.703196347032, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI115298650, Length=219, Percent_Identity=34.703196347032, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI6912520, Length=219, Percent_Identity=34.703196347032, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI190358497, Length=219, Percent_Identity=34.703196347032, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1789331, Length=347, Percent_Identity=43.2276657060519, Blast_Score=333, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTY_BUCAP (Q8K926)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660864.1
- ProteinModelPortal:   Q8K926
- SMR:   Q8K926
- EnsemblBacteria:   EBBUCT00000000342
- GeneID:   1005544
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg534
- GeneTree:   EBGT00050000007867
- HOGENOM:   HBG464473
- OMA:   AIMEFGA
- ProtClustDB:   CLSK493050
- BioCyc:   BAPH198804:BUSG534-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:1.10.340.30
- Gene3D:   G3DSA:1.10.1670.10
- Gene3D:   G3DSA:3.90.79.10
- SMART:   SM00478
- SMART:   SM00525
- SMART:   SM00278
- TIGRFAMs:   TIGR01084

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD; SSF48150 DNA_glycsylse; SSF55811 NUDIX_hydrolase

EC number: 3.2.2.-

Molecular weight: Translated: 41302; Mature: 41170

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS00764 ENDONUCLEASE_III_1; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFP
CEEHEEHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NIQSLNQSKLDDILCLWSGLGYYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRS
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKIEQKLWYLIELITPIHNTGSF
HHHHHHEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKY
CCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHEEECCCEEEEEEE
QNQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTL
CCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HIIPILVNLSFFKNFQNSKKTGIWYDLKNTHDIGLPKPVQKILEIFK
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHC
>Mature Secondary Structure 
TIYVFSQLILNWYHINGRKNLPWKKDKTLYKVWISEIMLQQTTVKTAIPYFKNFISRFP
EEHEEHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NIQSLNQSKLDDILCLWSGLGYYKRAENIYKTVKIIKEEFQEKFPTGFSDLIKLPGIGRS
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TAGAILSLSLDYFFPILEGNVKRILMRYYGIIGYVTEKKIEQKLWYLIELITPIHNTGSF
HHHHHHEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NQGIMDIGALICTPKNPKCNLCPLIQKCIAYKEKNWIKYPLKKKKKIILEKKSWFVVIKY
CCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHEEECCCEEEEEEE
QNQFWIEKNTEKKIWKNLFCFPNFDTKIKTIEWLKKNKINIDKKHKKIQSFYHKFSHFTL
CCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HIIPILVNLSFFKNFQNSKKTGIWYDLKNTHDIGLPKPVQKILEIFK
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438