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The map label for this gene is lon

Identifier: 21672726

GI number: 21672726

Start: 523305

End: 525638

Strand: Direct

Name: lon

Synonym: BUsg461

Alternate gene names: 21672726

Gene position: 523305-525638 (Clockwise)

Preceding gene: 21672725

Following gene: 21672727

Centisome position: 81.58

GC content: 29.69

Gene sequence:

>2334_bases
ATGAATTCTGAGCGTTCTGAACGCATTAAAATTCCCGTTTTACCGTTAAGAGATGTAGTTGTGTATCCTCACATGGTTAT
TCCATTATTTGTAGGTCGTAAAAAATCAATTCATTGCATTGAAACATCTATGAATAACGATAAAAAAATCATGCTAATTG
CACAAAAAGAAGCATCAAAAGACGAACCTAGTACAAATGATTTATTTAATATAGGAACTATTAGCTCAATTTTACAAATG
TTAAAACTACCAGATGGAACAGTAAAAGTACTAGTAGAGGGCTTACAACGTGCTTGTATTAAAAATATAGAAAGCAATGG
AGAACATTTAGTTGCTGAGGTAGAATTAATTATTTCTCCTACTGTTATAGATAAAGAACAAGAAGTATTAATTCGAACAA
CAGTTAATCAATTTGAGTCTTATATCAAACTTAATAAAAAAATTCCTTCAGAAATACTTAATACTCTTAGCCAAACGAAA
AATGCAGAAAAACTAGCAGATACAATTGCTGCTCATATGCCATTAAAATTAGCTGATAAACAGTCAGTATTGGAAATATA
TAATGTAAATGAAAGATTAGAATTTTTAATGGCTATAATGGAAACAGAAATAGATTTATTAAAAGTGGAAAAAAGAATTA
GAAATCGTGTTAAAAAACAAATGGAAAAGAGTCAAAGAGAATATTATCTCAATGAACAAATAAAAGCTATTCAAAAAGAA
CTTGGAGATATGGACGAAATTCCAGATGAAAATAAAATTTTAAAACGTAAGATTAAAAGTTTAAAAATGCCTAAAGAAGC
AAAAGAAAAAACAGAATCAGAATTACAAAAGTTAAAAATGATGTCACCAATGTCAGCAGAAGCGACAGTAGTACGAAGTT
ATATTGATTGGATGATACAGGTTCCTTGGAATATAAAAACAAAAATAAAAAAAGATATTCAAGAAGCAAAAAAAATTCTT
GATATAGACCATTTTGGTCTAGAAAAGGTAAAAGAACGCATATTAGAATATTTAGCTGTACAAAGTAGGACAAATAAAGT
TAAAGGTCCTATTTTGTGTTTAATAGGTCCTCCTGGGGTAGGTAAAACATCTTTAGGAAAATCTATTGCAAAATCAACAG
GTAGAAAATATGTAAGAATGGCTTTAGGTGGAATACGAGACGAAGCTGAAATTAGAGGTCATCGACGTACATATATTGGT
TCAATGCCTGGAAAATTAATGCAAAAAATGGTAAAAGCAAAGGTAAAAAATCCTTTATTTTTACTTGACGAAATTGATAA
AATGTCTTGTGATATAAGAGTTGATCCAGCATCTGCATTACTAGAAGTACTAGATCCTGAACAAAATATAAATTTTAATG
ATCATTATTTAGAAGTAGACTATGATCTTTCAGATGTTATGTTTGTAGCAACTTCTAACTCTATGAATATACCTGCACCA
TTACTTGATCGAATGGAAATAATCCGTCTTTCTGGTTATACAGAAAACGAAAAATTAAATATAGCGAAGTGCTATTTATA
TCCAAAACAAATGGAAAGAAATGCATTAAAAAGGAACGAACTCATCATTACTGATTGCGCTATAATTAGTATAATTCAAT
ATTATACTCGTGAAGCAGGAGTACGTAGTTTAGAACGTGAAATATCTAAAATATGTAGAAAAGTCGTAAAACTTTTAATT
TTAAATAAATCTTTAAAAAAAATAGAAATAAACAGTAAAAATTTAAAGAAATTTTTAGGAATAAAACGATTTGATTACGG
AAAAACAAACAATTTAAATCAAATCGGACAGGTTGTTGGATTGGCTTGGACAGAAGTAGGTGGAGAATTATTGACAATTG
AGACAGCATGTGTTTCAGGAAAAGGAAAACTTACTTACACAGGTTCTTTAGGTGAAGTTATGCAAGAATCAATTCAAGCT
GCATTAACTGTAGTTCGATCTCAAGCAAAAAAATTAGGAATTAAAAAAGATTTTCATGAAAAACATGATATTCATGTTCA
TGTTCCCGAAGGTGCTACACCGAAAGACGGTCCGAGTGCAGGTATCGCGATGTGTACAGCTATAGTATCTTCTTTAACAA
AGAATCCTGTCAAATCTAATATTGCGATGACAGGAGAAATTACATTACAAGGAAGGGTATTAACAATAGGAGGACTAAAA
GAAAAATTACTTGCAGCACATCGTGGAGGTGTTAAAACTGTGTTAATACCATATGAAAATAAACGTAATTTAGAAGAAAT
ACCAAAAAATATTATTGAAGGACTAACAATTTATCCAGTAAAGAATATCGAAGAAGTTTTAAAAATAGCATTAGAAAATA
CACCTTACGTATAA

Upstream 100 bases:

>100_bases
TATACTTGGCTTAAGTATAAATAGAGCTGCATATTATTTTATAATAAATTGCAGTTTTTAATAAATATAAACAGCGGAAA
TTCAACTAAGAGAGAGCTCT

Downstream 100 bases:

>100_bases
AAGATCTAAATTTGGCTGACAAAAAACCGTCAGCCTTTATAATTTAAATAAAAAAATTAAAAATTTCAATATAAAATTGA
AACTATCTAGGATAGTTATA

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 777; Mature: 777

Protein sequence:

>777_residues
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASKDEPSTNDLFNIGTISSILQM
LKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISPTVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTK
NAEKLADTIAAHMPLKLADKQSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKE
LGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQVPWNIKTKIKKDIQEAKKIL
DIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGVGKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKMVKAKVKNPLFLLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAGVRSLEREISKICRKVVKLLI
LNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVGLAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQA
ALTVVRSQAKKLGIKKDFHEKHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLK
EKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV

Sequences:

>Translated_777_residues
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASKDEPSTNDLFNIGTISSILQM
LKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISPTVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTK
NAEKLADTIAAHMPLKLADKQSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKE
LGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQVPWNIKTKIKKDIQEAKKIL
DIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGVGKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKMVKAKVKNPLFLLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAGVRSLEREISKICRKVVKLLI
LNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVGLAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQA
ALTVVRSQAKKLGIKKDFHEKHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLK
EKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV
>Mature_777_residues
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASKDEPSTNDLFNIGTISSILQM
LKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISPTVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTK
NAEKLADTIAAHMPLKLADKQSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKE
LGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQVPWNIKTKIKKDIQEAKKIL
DIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGVGKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKMVKAKVKNPLFLLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAGVRSLEREISKICRKVVKLLI
LNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVGLAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQA
ALTVVRSQAKKLGIKKDFHEKHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLK
EKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=778, Percent_Identity=38.1748071979434, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI21396489, Length=689, Percent_Identity=39.0420899854862, Blast_Score=499, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=775, Percent_Identity=78.3225806451613, Blast_Score=1271, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=632, Percent_Identity=40.1898734177215, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=804, Percent_Identity=33.7064676616915, Blast_Score=417, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=652, Percent_Identity=40.4907975460123, Blast_Score=475, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24666867, Length=685, Percent_Identity=41.021897810219, Blast_Score=510, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=685, Percent_Identity=41.021897810219, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_BUCAP (Q8K988)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660793.1
- ProteinModelPortal:   Q8K988
- MEROPS:   S16.001
- EnsemblBacteria:   EBBUCT00000000422
- GeneID:   1005704
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg461
- GeneTree:   EBGT00050000007957
- HOGENOM:   HBG566281
- OMA:   IQKMSKV
- ProtClustDB:   CLSK316282
- BioCyc:   BAPH198804:BUSG461-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 87756; Mature: 87756

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 679-679 ACT_SITE 722-722

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASK
CCCCCCCEEEECCCCHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCC
DEPSTNDLFNIGTISSILQMLKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISP
CCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECC
TVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTKNAEKLADTIAAHMPLKLADK
CEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCH
QSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQ
HCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
VPWNIKTKIKKDIQEAKKILDIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGV
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIGSMPGKLMQKMVKAKVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCEE
LLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAP
EEECCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAG
HHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
VRSLEREISKICRKVVKLLILNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVG
HHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQAALTVVRSQAKKLGIKKDFHE
HHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
KHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCHH
EKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASK
CCCCCCCEEEECCCCHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCC
DEPSTNDLFNIGTISSILQMLKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISP
CCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECC
TVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTKNAEKLADTIAAHMPLKLADK
CEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCH
QSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQ
HCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
VPWNIKTKIKKDIQEAKKILDIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGV
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
GKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIGSMPGKLMQKMVKAKVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCEE
LLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAP
EEECCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAG
HHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
VRSLEREISKICRKVVKLLILNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVG
HHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQAALTVVRSQAKKLGIKKDFHE
HHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
KHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEECCHH
EKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438