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The map label for this gene is mltA

Identifier: 21672707

GI number: 21672707

Start: 505593

End: 506693

Strand: Direct

Name: mltA

Synonym: BUsg442

Alternate gene names: 21672707

Gene position: 505593-506693 (Clockwise)

Preceding gene: 21672705

Following gene: 21672708

Centisome position: 78.82

GC content: 23.8

Gene sequence:

>1101_bases
ATGCTTAATTCTTGCATTAATAAAATTAAAAAGAAAAAAAATATAAAAAAAATAATTTTAATGTTGATTTTTATCTTTTC
AGTCAATTTTTTCACTAAAAATACAAATCAAGGTAAACAATATGAAGATAAATTAAACAAAGATTTTACGAATATAAAAA
AAATAAATATAAAAAACAAATTAGTTAATCAAAAAGAATTTCTTCTACAACTTGAAAAAATTAAAATTTTCTCTCCAAAT
CTATATTCGAAAAATATATCTATTTATAACGCTATATTAAAATGGTTAAAAAAAAGAGCAGAAATAAATGAACTAAATAA
ATTTAGAATAAAGTTATTTCAAATGAAAGGCGTAGATCAATATGGAAATGTTAAGATAACCGGATACTATACACCAATAG
TAAAAGCCAGTAAGATCAAAAAAAATAACTTTATATATCCGATATACAGAACACCTTCTAATTTTAAAAAAAATGAAAAA
TTACCACAAAGAAAAGATATATACAATGGTTTTTTAAAAAAAGAATATATTTTAGCTTATAGCGATTCTTTAATAAATAA
TTTTATTATGGAAATTCAAGGTAGTGGTTTTATAGATTATGGTGATAACAAACCATTAATTTTTTTTGGTTATGCAAAAA
AAAATAATTGGCCTTATACAAGTATTGGTCAAATTTTAATCAAAAATGGCGATATACAAAAAAAAAATATTTCAATGAAC
ACTATTAAAAACTGGTGTACACACCATACTCAAAAGGAAATACAAAATTTACTTGAAAAAAATAAATCCTTTGTTTTCTT
TCAAGAAACCAAAAGAAAAGAGGTATACGGTTCTAGCGCAGTGCCATTAGTTGAAAAAGCAGCTATAGCTGTAGATAAAT
CAGTAATAAAAATTGGAAGTGTCGTATTAGTAAAAATACCTGTTCTTGATAAAAACGGCATTTTTATTCATAAATATGAA
ATGCATTTACTAATTGCATTAGATGTAGGAGGTGTCATTAAAGGACAACATTTTGATGTATATCAAGGAATCGGAGAAAA
AGCTGGTAAATTGGCAGGTTTTTATAACCATTATGGATACGCTTGGGTACTGAAAATTTAA

Upstream 100 bases:

>100_bases
AAAAAGCAACCTTTTTAAAAAAATTTTTTAAAAAAATTTTTAAATATTATGCTTATATTATGCTTATTAAAAAAACTTAA
AAATATTTAATAAAACTGCT

Downstream 100 bases:

>100_bases
CTCAAAAAACATAAACAAAAAGGAAAAAAAATGAATATAATTCAATCAGGAATCAACGTTAAAAATGCTTCTATTACTAT
AATAATAGCAAGATTTAATG

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MLNSCINKIKKKKNIKKIILMLIFIFSVNFFTKNTNQGKQYEDKLNKDFTNIKKINIKNKLVNQKEFLLQLEKIKIFSPN
LYSKNISIYNAILKWLKKRAEINELNKFRIKLFQMKGVDQYGNVKITGYYTPIVKASKIKKNNFIYPIYRTPSNFKKNEK
LPQRKDIYNGFLKKEYILAYSDSLINNFIMEIQGSGFIDYGDNKPLIFFGYAKKNNWPYTSIGQILIKNGDIQKKNISMN
TIKNWCTHHTQKEIQNLLEKNKSFVFFQETKRKEVYGSSAVPLVEKAAIAVDKSVIKIGSVVLVKIPVLDKNGIFIHKYE
MHLLIALDVGGVIKGQHFDVYQGIGEKAGKLAGFYNHYGYAWVLKI

Sequences:

>Translated_366_residues
MLNSCINKIKKKKNIKKIILMLIFIFSVNFFTKNTNQGKQYEDKLNKDFTNIKKINIKNKLVNQKEFLLQLEKIKIFSPN
LYSKNISIYNAILKWLKKRAEINELNKFRIKLFQMKGVDQYGNVKITGYYTPIVKASKIKKNNFIYPIYRTPSNFKKNEK
LPQRKDIYNGFLKKEYILAYSDSLINNFIMEIQGSGFIDYGDNKPLIFFGYAKKNNWPYTSIGQILIKNGDIQKKNISMN
TIKNWCTHHTQKEIQNLLEKNKSFVFFQETKRKEVYGSSAVPLVEKAAIAVDKSVIKIGSVVLVKIPVLDKNGIFIHKYE
MHLLIALDVGGVIKGQHFDVYQGIGEKAGKLAGFYNHYGYAWVLKI
>Mature_366_residues
MLNSCINKIKKKKNIKKIILMLIFIFSVNFFTKNTNQGKQYEDKLNKDFTNIKKINIKNKLVNQKEFLLQLEKIKIFSPN
LYSKNISIYNAILKWLKKRAEINELNKFRIKLFQMKGVDQYGNVKITGYYTPIVKASKIKKNNFIYPIYRTPSNFKKNEK
LPQRKDIYNGFLKKEYILAYSDSLINNFIMEIQGSGFIDYGDNKPLIFFGYAKKNNWPYTSIGQILIKNGDIQKKNISMN
TIKNWCTHHTQKEIQNLLEKNKSFVFFQETKRKEVYGSSAVPLVEKAAIAVDKSVIKIGSVVLVKIPVLDKNGIFIHKYE
MHLLIALDVGGVIKGQHFDVYQGIGEKAGKLAGFYNHYGYAWVLKI

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=357, Percent_Identity=45.0980392156863, Blast_Score=356, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MLTA_BUCAP (Q8K9A7)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660774.1
- ProteinModelPortal:   Q8K9A7
- SMR:   Q8K9A7
- EnsemblBacteria:   EBBUCT00000000208
- GeneID:   1005722
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg442
- GeneTree:   EBGT00050000007825
- HOGENOM:   HBG296995
- OMA:   NQGDFLT
- ProtClustDB:   PRK11162
- BioCyc:   BAPH198804:BUSG442-MONOMER
- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300
- Gene3D:   G3DSA:2.40.40.10
- SMART:   SM00925

Pfam domain/function: PF06725 3D; PF03562 MltA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42546; Mature: 42546

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSCINKIKKKKNIKKIILMLIFIFSVNFFTKNTNQGKQYEDKLNKDFTNIKKINIKNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHEEEEEHHHH
LVNQKEFLLQLEKIKIFSPNLYSKNISIYNAILKWLKKRAEINELNKFRIKLFQMKGVDQ
HCCHHHHHHEEEHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
YGNVKITGYYTPIVKASKIKKNNFIYPIYRTPSNFKKNEKLPQRKDIYNGFLKKEYILAY
CCCEEEEEEECCCEECCEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEE
SDSLINNFIMEIQGSGFIDYGDNKPLIFFGYAKKNNWPYTSIGQILIKNGDIQKKNISMN
HHHHHHHHHHEECCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHH
TIKNWCTHHTQKEIQNLLEKNKSFVFFQETKRKEVYGSSAVPLVEKAAIAVDKSVIKIGS
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VVLVKIPVLDKNGIFIHKYEMHLLIALDVGGVIKGQHFDVYQGIGEKAGKLAGFYNHYGY
EEEEEEEEECCCCEEEEEEEEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCE
AWVLKI
EEEEEC
>Mature Secondary Structure
MLNSCINKIKKKKNIKKIILMLIFIFSVNFFTKNTNQGKQYEDKLNKDFTNIKKINIKNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHEEEEEHHHH
LVNQKEFLLQLEKIKIFSPNLYSKNISIYNAILKWLKKRAEINELNKFRIKLFQMKGVDQ
HCCHHHHHHEEEHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
YGNVKITGYYTPIVKASKIKKNNFIYPIYRTPSNFKKNEKLPQRKDIYNGFLKKEYILAY
CCCEEEEEEECCCEECCEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHEEEEE
SDSLINNFIMEIQGSGFIDYGDNKPLIFFGYAKKNNWPYTSIGQILIKNGDIQKKNISMN
HHHHHHHHHHEECCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHH
TIKNWCTHHTQKEIQNLLEKNKSFVFFQETKRKEVYGSSAVPLVEKAAIAVDKSVIKIGS
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCC
VVLVKIPVLDKNGIFIHKYEMHLLIALDVGGVIKGQHFDVYQGIGEKAGKLAGFYNHYGY
EEEEEEEEECCCCEEEEEEEEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCE
AWVLKI
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438