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The map label for this gene is rpoC

Identifier: 21672327

GI number: 21672327

Start: 36463

End: 40704

Strand: Reverse

Name: rpoC

Synonym: BUsg034

Alternate gene names: 21672327

Gene position: 40704-36463 (Counterclockwise)

Preceding gene: 21672328

Following gene: 21672326

Centisome position: 6.35

GC content: 32.37

Gene sequence:

>4242_bases
GTGAAAGATTTACTAAAATTTTTAAAAGCCCAAACTAAAAATGAGGATTTTGATGCTATTAAAATTTCTCTAGCATCACC
TGATATGATTAGATCTTGGTCATTTGGTGAAGTTAAAAAACCAGAAACTATTAATTATCGTACATTTAAACCTGAACGAG
ACGGACTATTTTGTGCACGTATTTTTGGTCCAGTAAAAGATTATGAATGTTTATGCGGAAAATATAAAAGATTAAAACAT
CGAGGTGTTATTTGTGAAAAATGCGGTGTTGAAGTAACACAAAGTAAAGTTAGACGTGAACGAATGGGTCATATAGAACT
TTCTTCTCCTACAGCTCATATTTGGTTTTTAAAATCATTACCATCACGTATAGGTTTATTATTAGACATGCCTTTAAGAG
ATATTGAAAGAGTACTATATTTTGAATCTTATGTTGTTATTGAAACAGGTATGACAAATCTTGAAAAACGTCAAATTTTA
ACTGAAGAACAATATCTAGATGCATTAGAAGAATTTGGAGACGAATTTTATGCAACAATGGGAGCAGAAGCAATTCAATC
TTTATTAAAAGATATAAATTTAGTAAAAGAATGTGAAAACTTAAGAATAGAACTTAATGAGACGAATTCGGAAACAAAGC
GAAAAAAATTAACTAAAAGAATTAAATTATTAGAATCTTTTATACAATCTAATAATAAACCAGAATGGATGATTTTAACT
GTTTTACCAGTATTGCCACCTGATCTAAGACCATTAGTACCATTAGATGGAGGAAGATTTGCAACATCTGATCTAAACGA
TTTATATCGTCGCGTCATTAACAGAAACAATAGATTAAAAAGATTATTAGATTTAGCAGCACCTGATATCATTGTTAGAA
ATGAAAAAAGAATGTTACAAGAAGCAATAGATGCTTTACTAGATAATGGTAGAAGAGGAAGAGCCATTACTGGTTCAAAT
AAAAGACCTCTTAAATCATTAGCAGATATGATTAAAGGAAAACAAGGTAGATTCCGACAAAATCTTCTTGGAAAACGCGT
TGATTATTCCGGACGATCAGTTATTACTGTAGGACCTTATCTTCGTTTACATCAATGTGGCTTACCTAAAAAAATGGCAT
TAGAACTTTTTAAACCATTTATATATGGAAAATTAGAAGTTCGTGGATTGGCAACTACCATAAAAGCCGCAAAAAAAATG
GTTGAAAGAGAAGAAGCAATAGTATGGGATATATTAGACGAAGTTATTCGAGAACATCCTGTTCTTTTGAATCGTGCACC
TACTTTACATAGATTAGGAATACAAGCATTTGAACCCGTTTTAATAGAAGGTAAAGCTATTCAATTACATCCATTAGTTT
GTGCGGCTTATAATGCTGATTTTGATGGAGATCAGATGGCTGTTCATGTTCCATTAACTCTAGAAGCTCAATTAGAAGCT
AGAGCTTTAATGATGTCTACAAATAATATACTTTCTCCAGCTAATGGTGAACCAATTATCGTACCATCTCAAGATGTAGT
CTTAGGGCTTTATTATATGACTCGCGAAAAAATAAATGGAAAGGGAGAGGGAATGATTTTAAACGGTTCTAATGAAGCAG
AAAAAGTATATCGTTTAGAAATTGCAGAGTTACATTCTCTAGTTAAGGTACGCATAACAGAATACAAAAAAAATAAAGAT
CAAAGTTTTATTCCTAAAACAAAGATAATAAACACTACAATAGGACGAGCTATTTTATGGATGATTGTTCCTAAAGGATT
GCCATTTAGTATTGTTAATCAAACTTTAGGAAAAAAAGACATTTCTAAAATGTTAAATACTTGCTATCGTATTTTAGGTT
TAAAACCTACTGTTGCTTTTGCCGATCAGATCATGTATACAGGTTTTGCTTATGCAGCAAGATCTGGAGCTTCGGTTGGT
ATTGACGACATGGTCATACCTGTAAAAAAATTAAATATTATTCATGAAGCAGAAATAGAAGTAGCTGAAATACAAGAACA
GTTTCAATCTGGATTAGTTACGGCAGGTGAAAGATATAACAAAGTCATTGATATTTGGGCAGCAGCTAACGAAAGAGTAG
CTAAAGCAATGATGGAAAACTTATCTACAGAATCTGTATTTAATAAAAAAGGCGAGAAACAGAAACAAATCTCTTTTAAT
AGTATATTTATGATGGCCGATTCGGGTGCTCGCGGGTCTGCTGCACAAATTCGTCAATTAGCAGGAATGAGAGGACTGAT
GGCAAAACCAGATGGATCAATTATTGAAACGCCTATAACAGCTAATTTTAGAGAAGGTCTAAACGTATTACAATATTTTA
TTTCAACTCATGGAGCACGAAAGGGTTTAGCTGATACAGCATTAAAAACAGCTAATTCTGGTTATTTGACACGCCGTTTA
GTAGATGTTGCACAAGATTTAGTTGTAACACAAAATGATTGCGGAACACATGAAGGAATTTTAATGACTCCTTTAATAGA
AGGAGGAGATGTCAAAGAACCATTACGTGAACGTGTTTTAGGTCGTGTCACAGCAGAAAAAATATTAATTCCCAATACTG
AAAATATATTAATTGAAAGAAATACTTTATTAAACGAGCAATGGTGTGATCTTTTAGAAAAAAATTCTATAGATAATGTG
AAAGTAAGATCAGTAGTAAATTGTGAAACTGATTTTGGTGTTTGTGCTTACTGTTATGGTCGTGATTTAGCAAGAGGTAA
CTTAGTTAATAAAGGAGAAGCAATAGGAGTAATAGCAGCACAATCTATAGGAGAACCAGGTACGCAATTAACTATGCGAA
CTTTTCATATTGGTGGTGCAGCATCAAGGGCAGCTACTGAATCTAGTATTCAAATAAAAAATAAAGGCATAATCAATCTT
AATAACGCAAAGTCTGTTACTAATTCTTCAGGTAAGATAGTTATAACTTCAAGAAATGTAGAACTTAATATAATTGATAA
TTTTAGAAGAACAAAAGAAACTTATAAAGTTCCTTATGGAGCTATTATGGCTAAAGGCCATGGAGAGCAAGTTAATTCTG
GAGAAACAGTAGCAAAATGGGATCCTCATACCATACCTGTTATTACTGAAGTGAGCGGATTTGTTCGATTTGTAGATATG
ATAGACGGTCAAAGTATTACAAGACAAGCCGATGAACTAACTGGATTATCTTCTATAGTTGTACTAGATACAGCAGAAAG
AATGACAATTGGAAAAGATTTAAGACCTTCATTAAAAATTGTTGATCGTGATGGAAATGACGTTCTTATTTCAGGAACAG
AAATGCCAGCACAGTATTTTTTACCTGGGAAAGCAATTGTTCAACTTGATGACAGAGTACAAATTAGTTCTGGTGACACT
TTAGCAAGAGTACCACAAGAATCAGGAGGTACTAAAGATATAACTGGTGGACTACCAAGAGTTGCAGATTTATTTGAAGC
TAGACGTCCAAAAGAATTAGCGATTTTAGCTGAAATAAGTGGAATTATATCTTTTGGAAAAGAAACAAAAGGGAAAAGAA
GACTAATTATTACTCCAGTAGACGGAAGTGATGCATATGAAGAAATGATTCCAAAATGGAGACAATTGAATGTTTTTGAA
GGAGAAAGAGTTGAACGAGGTGATGTTATATCAGATGGACCCGAATCACCACACGATATTCTTCGTTTAAGAGGAGTGCA
GGCTGTAACTAAATATATTGTAAATGAAGTACAAGAAGTATATCGTTTACAAGGTGTAAAAATTAATGATAAACATATTG
AAGTAATAATTAGACAAATGCTTCGAAAAGCTACTGTCATTAAATCAGGAAATTCAGAATTTTTAGATGGAGAACAAGTA
GAATTTTCTCGAATAAAAATTTCAAATCGTATTTTAAATAAACAAAGTAAAATACCTGCAACTTTTTCAAGAGATTTATT
AGGCATTACTAAAGCATCTCTTGCAACTGAATCTTTTATATCAGCAGCTTCTTTTCAGGAAACAACTAGAGTTTTAACAG
AATCTGCAGTTGCAGGAAAAAAAGACGAATTACGAGGATTAAAAGAAAATGTTATTGTTGGACGTTTAATACCTGCAGGT
ACTGGATATGCATATCATAAAGAACGTTTAAATCGTCGTCATACAGTAAATACCAATCAAATAAAACCTAATAACTCTTC
TTCTCAAATTAGTGCAGAAGAAGCATCTGCAAGTTTATCAGAATTATTAAATTCCACTCTTATACAACATGATCATACAT
AA

Upstream 100 bases:

>100_bases
TAGGTATTAATATTGAATTAGAAAATGAATAAAATTTAAAATAATATAAGACATATAGATTTACCACCTTCAAAAATTTC
ACTCCAACGAGAGCTCATGC

Downstream 100 bases:

>100_bases
ATAATTTTAAAATAATTATATTATGGCTGCTCTTAAAAGCAGCCAAAATATGGAAAAATAGCATTTCTTATCTTATCAAA
TAAACTTTAAAAGTTATAAA

Product: DNA-directed RNA polymerase subunit beta'

Products: NA

Alternate protein names: RNAP subunit beta'; RNA polymerase subunit beta'; Transcriptase subunit beta'

Number of amino acids: Translated: 1413; Mature: 1413

Protein sequence:

>1413_residues
MKDLLKFLKAQTKNEDFDAIKISLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKH
RGVICEKCGVEVTQSKVRRERMGHIELSSPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIETGMTNLEKRQIL
TEEQYLDALEEFGDEFYATMGAEAIQSLLKDINLVKECENLRIELNETNSETKRKKLTKRIKLLESFIQSNNKPEWMILT
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAIDALLDNGRRGRAITGSN
KRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLEVRGLATTIKAAKKM
VEREEAIVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREKINGKGEGMILNGSNEAEKVYRLEIAELHSLVKVRITEYKKNKD
QSFIPKTKIINTTIGRAILWMIVPKGLPFSIVNQTLGKKDISKMLNTCYRILGLKPTVAFADQIMYTGFAYAARSGASVG
IDDMVIPVKKLNIIHEAEIEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTESVFNKKGEKQKQISFN
SIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRL
VDVAQDLVVTQNDCGTHEGILMTPLIEGGDVKEPLRERVLGRVTAEKILIPNTENILIERNTLLNEQWCDLLEKNSIDNV
KVRSVVNCETDFGVCAYCYGRDLARGNLVNKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAATESSIQIKNKGIINL
NNAKSVTNSSGKIVITSRNVELNIIDNFRRTKETYKVPYGAIMAKGHGEQVNSGETVAKWDPHTIPVITEVSGFVRFVDM
IDGQSITRQADELTGLSSIVVLDTAERMTIGKDLRPSLKIVDRDGNDVLISGTEMPAQYFLPGKAIVQLDDRVQISSGDT
LARVPQESGGTKDITGGLPRVADLFEARRPKELAILAEISGIISFGKETKGKRRLIITPVDGSDAYEEMIPKWRQLNVFE
GERVERGDVISDGPESPHDILRLRGVQAVTKYIVNEVQEVYRLQGVKINDKHIEVIIRQMLRKATVIKSGNSEFLDGEQV
EFSRIKISNRILNKQSKIPATFSRDLLGITKASLATESFISAASFQETTRVLTESAVAGKKDELRGLKENVIVGRLIPAG
TGYAYHKERLNRRHTVNTNQIKPNNSSSQISAEEASASLSELLNSTLIQHDHT

Sequences:

>Translated_1413_residues
MKDLLKFLKAQTKNEDFDAIKISLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKH
RGVICEKCGVEVTQSKVRRERMGHIELSSPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIETGMTNLEKRQIL
TEEQYLDALEEFGDEFYATMGAEAIQSLLKDINLVKECENLRIELNETNSETKRKKLTKRIKLLESFIQSNNKPEWMILT
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAIDALLDNGRRGRAITGSN
KRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLEVRGLATTIKAAKKM
VEREEAIVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREKINGKGEGMILNGSNEAEKVYRLEIAELHSLVKVRITEYKKNKD
QSFIPKTKIINTTIGRAILWMIVPKGLPFSIVNQTLGKKDISKMLNTCYRILGLKPTVAFADQIMYTGFAYAARSGASVG
IDDMVIPVKKLNIIHEAEIEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTESVFNKKGEKQKQISFN
SIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRL
VDVAQDLVVTQNDCGTHEGILMTPLIEGGDVKEPLRERVLGRVTAEKILIPNTENILIERNTLLNEQWCDLLEKNSIDNV
KVRSVVNCETDFGVCAYCYGRDLARGNLVNKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAATESSIQIKNKGIINL
NNAKSVTNSSGKIVITSRNVELNIIDNFRRTKETYKVPYGAIMAKGHGEQVNSGETVAKWDPHTIPVITEVSGFVRFVDM
IDGQSITRQADELTGLSSIVVLDTAERMTIGKDLRPSLKIVDRDGNDVLISGTEMPAQYFLPGKAIVQLDDRVQISSGDT
LARVPQESGGTKDITGGLPRVADLFEARRPKELAILAEISGIISFGKETKGKRRLIITPVDGSDAYEEMIPKWRQLNVFE
GERVERGDVISDGPESPHDILRLRGVQAVTKYIVNEVQEVYRLQGVKINDKHIEVIIRQMLRKATVIKSGNSEFLDGEQV
EFSRIKISNRILNKQSKIPATFSRDLLGITKASLATESFISAASFQETTRVLTESAVAGKKDELRGLKENVIVGRLIPAG
TGYAYHKERLNRRHTVNTNQIKPNNSSSQISAEEASASLSELLNSTLIQHDHT
>Mature_1413_residues
MKDLLKFLKAQTKNEDFDAIKISLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKH
RGVICEKCGVEVTQSKVRRERMGHIELSSPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIETGMTNLEKRQIL
TEEQYLDALEEFGDEFYATMGAEAIQSLLKDINLVKECENLRIELNETNSETKRKKLTKRIKLLESFIQSNNKPEWMILT
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAIDALLDNGRRGRAITGSN
KRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLEVRGLATTIKAAKKM
VEREEAIVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREKINGKGEGMILNGSNEAEKVYRLEIAELHSLVKVRITEYKKNKD
QSFIPKTKIINTTIGRAILWMIVPKGLPFSIVNQTLGKKDISKMLNTCYRILGLKPTVAFADQIMYTGFAYAARSGASVG
IDDMVIPVKKLNIIHEAEIEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTESVFNKKGEKQKQISFN
SIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRL
VDVAQDLVVTQNDCGTHEGILMTPLIEGGDVKEPLRERVLGRVTAEKILIPNTENILIERNTLLNEQWCDLLEKNSIDNV
KVRSVVNCETDFGVCAYCYGRDLARGNLVNKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAATESSIQIKNKGIINL
NNAKSVTNSSGKIVITSRNVELNIIDNFRRTKETYKVPYGAIMAKGHGEQVNSGETVAKWDPHTIPVITEVSGFVRFVDM
IDGQSITRQADELTGLSSIVVLDTAERMTIGKDLRPSLKIVDRDGNDVLISGTEMPAQYFLPGKAIVQLDDRVQISSGDT
LARVPQESGGTKDITGGLPRVADLFEARRPKELAILAEISGIISFGKETKGKRRLIITPVDGSDAYEEMIPKWRQLNVFE
GERVERGDVISDGPESPHDILRLRGVQAVTKYIVNEVQEVYRLQGVKINDKHIEVIIRQMLRKATVIKSGNSEFLDGEQV
EFSRIKISNRILNKQSKIPATFSRDLLGITKASLATESFISAASFQETTRVLTESAVAGKKDELRGLKENVIVGRLIPAG
TGYAYHKERLNRRHTVNTNQIKPNNSSSQISAEEASASLSELLNSTLIQHDHT

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG0086

COG function: function code K; DNA-directed RNA polymerase, beta' subunit/160 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA polymerase beta' chain family

Homologues:

Organism=Homo sapiens, GI4505939, Length=930, Percent_Identity=24.6236559139785, Blast_Score=190, Evalue=7e-48,
Organism=Homo sapiens, GI39725938, Length=308, Percent_Identity=31.8181818181818, Blast_Score=137, Evalue=8e-32,
Organism=Homo sapiens, GI103471997, Length=593, Percent_Identity=25.6323777403035, Blast_Score=127, Evalue=7e-29,
Organism=Escherichia coli, GI2367335, Length=1412, Percent_Identity=86.2606232294618, Blast_Score=2524, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987878, Length=912, Percent_Identity=24.780701754386, Blast_Score=180, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25145495, Length=311, Percent_Identity=31.5112540192926, Blast_Score=149, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324690, Length=692, Percent_Identity=25.5780346820809, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320061, Length=668, Percent_Identity=26.1976047904192, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17530899, Length=838, Percent_Identity=24.2243436754177, Blast_Score=180, Evalue=6e-45,
Organism=Drosophila melanogaster, GI281360912, Length=715, Percent_Identity=25.4545454545455, Blast_Score=171, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPOC_BUCAP (P41185)

Other databases:

- EMBL:   AE013218
- EMBL:   Z11913
- PIR:   S32681
- RefSeq:   NP_660394.1
- ProteinModelPortal:   P41185
- EnsemblBacteria:   EBBUCT00000000338
- GeneID:   1005850
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg034
- GeneTree:   EBGT00050000008021
- HOGENOM:   HBG621785
- OMA:   FEARVPK
- ProtClustDB:   PRK00566
- BioCyc:   BAPH198804:BUSG034-MONOMER
- HAMAP:   MF_01322
- InterPro:   IPR000722
- InterPro:   IPR006592
- InterPro:   IPR007080
- InterPro:   IPR007066
- InterPro:   IPR007083
- InterPro:   IPR007081
- InterPro:   IPR012754
- SMART:   SM00663
- TIGRFAMs:   TIGR02386

Pfam domain/function: PF04997 RNA_pol_Rpb1_1; PF00623 RNA_pol_Rpb1_2; PF04983 RNA_pol_Rpb1_3; PF05000 RNA_pol_Rpb1_4; PF04998 RNA_pol_Rpb1_5

EC number: =2.7.7.6

Molecular weight: Translated: 157683; Mature: 157683

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLLKFLKAQTKNEDFDAIKISLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCAR
CHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEH
IFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQSKVRRERMGHIELSSPTAHIWFLKSL
HHCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCEEECCCCEEEEEHHHH
PSRIGLLLDMPLRDIERVLYFESYVVIETGMTNLEKRQILTEEQYLDALEEFGDEFYATM
HHHHCEEECCCHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAEAIQSLLKDINLVKECENLRIELNETNSETKRKKLTKRIKLLESFIQSNNKPEWMILT
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQ
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHH
EAIDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPY
HHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
LRLHQCGLPKKMALELFKPFIYGKLEVRGLATTIKAAKKMVEREEAIVWDILDEVIREHP
HHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
EEECCCCCHHHHCHHHCCCEEEECCEEEEECEEEEEECCCCCCCCEEEEEEEEEECCHHH
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREKINGKGEGMILNGSNEAEKVYRLE
HEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
IAELHSLVKVRITEYKKNKDQSFIPKTKIINTTIGRAILWMIVPKGLPFSIVNQTLGKKD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEHCCCCCCCHHHHHHHCCHHH
ISKMLNTCYRILGLKPTVAFADQIMYTGFAYAARSGASVGIDDMVIPVKKLNIIHEAEIE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHCCHHHCCCH
VAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTESVFNKKGEKQKQISFN
HHHHHHHHHCCCCCCCHHHHHEEEEEHHCHHHHHHHHHHHCCHHHHHHCCCCHHHCEEEE
SIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGAR
EEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCC
KGLADTALKTANSGYLTRRLVDVAQDLVVTQNDCGTHEGILMTPLIEGGDVKEPLRERVL
CCHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHH
GRVTAEKILIPNTENILIERNTLLNEQWCDLLEKNSIDNVKVRSVVNCETDFGVCAYCYG
HHHHHCEEECCCCCCEEEECCHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECC
RDLARGNLVNKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAATESSIQIKNKGIINL
CCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHCCCCCEEEECCCEEEE
NNAKSVTNSSGKIVITSRNVELNIIDNFRRTKETYKVPYGAIMAKGHGEQVNSGETVAKW
CCCCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEC
DPHTIPVITEVSGFVRFVDMIDGQSITRQADELTGLSSIVVLDTAERMTIGKDLRPSLKI
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCCCEEE
VDRDGNDVLISGTEMPAQYFLPGKAIVQLDDRVQISSGDTLARVPQESGGTKDITGGLPR
EECCCCEEEEECCCCCHHHCCCCCEEEEECCEEEECCCCCCEECCCCCCCCCCCCCCCHH
VADLFEARRPKELAILAEISGIISFGKETKGKRRLIITPVDGSDAYEEMIPKWRQLNVFE
HHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCHHHCCCCCC
GERVERGDVISDGPESPHDILRLRGVQAVTKYIVNEVQEVYRLQGVKINDKHIEVIIRQM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHH
LRKATVIKSGNSEFLDGEQVEFSRIKISNRILNKQSKIPATFSRDLLGITKASLATESFI
HHHHHHHCCCCCCCCCCCCCCHHHEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SAASFQETTRVLTESAVAGKKDELRGLKENVIVGRLIPAGTGYAYHKERLNRRHTVNTNQ
HHHHHHHHHHHHHHHHHCCCHHHHCCHHHCEEEEEEECCCCCCHHHHHHCCCCCCCCCCC
IKPNNSSSQISAEEASASLSELLNSTLIQHDHT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKDLLKFLKAQTKNEDFDAIKISLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCAR
CHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEH
IFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQSKVRRERMGHIELSSPTAHIWFLKSL
HHCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCEEECCCCEEEEEHHHH
PSRIGLLLDMPLRDIERVLYFESYVVIETGMTNLEKRQILTEEQYLDALEEFGDEFYATM
HHHHCEEECCCHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAEAIQSLLKDINLVKECENLRIELNETNSETKRKKLTKRIKLLESFIQSNNKPEWMILT
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQ
EECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHH
EAIDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPY
HHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
LRLHQCGLPKKMALELFKPFIYGKLEVRGLATTIKAAKKMVEREEAIVWDILDEVIREHP
HHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
EEECCCCCHHHHCHHHCCCEEEECCEEEEECEEEEEECCCCCCCCEEEEEEEEEECCHHH
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTREKINGKGEGMILNGSNEAEKVYRLE
HEEEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
IAELHSLVKVRITEYKKNKDQSFIPKTKIINTTIGRAILWMIVPKGLPFSIVNQTLGKKD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEEHCCCCCCCHHHHHHHCCHHH
ISKMLNTCYRILGLKPTVAFADQIMYTGFAYAARSGASVGIDDMVIPVKKLNIIHEAEIE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHCCHHHCCCH
VAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTESVFNKKGEKQKQISFN
HHHHHHHHHCCCCCCCHHHHHEEEEEHHCHHHHHHHHHHHCCHHHHHHCCCCHHHCEEEE
SIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGAR
EEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCC
KGLADTALKTANSGYLTRRLVDVAQDLVVTQNDCGTHEGILMTPLIEGGDVKEPLRERVL
CCHHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHH
GRVTAEKILIPNTENILIERNTLLNEQWCDLLEKNSIDNVKVRSVVNCETDFGVCAYCYG
HHHHHCEEECCCCCCEEEECCHHCCHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEECC
RDLARGNLVNKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAATESSIQIKNKGIINL
CCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHCCCCCEEEECCCEEEE
NNAKSVTNSSGKIVITSRNVELNIIDNFRRTKETYKVPYGAIMAKGHGEQVNSGETVAKW
CCCCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEC
DPHTIPVITEVSGFVRFVDMIDGQSITRQADELTGLSSIVVLDTAERMTIGKDLRPSLKI
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECHHHHHCCCCCCCCEEE
VDRDGNDVLISGTEMPAQYFLPGKAIVQLDDRVQISSGDTLARVPQESGGTKDITGGLPR
EECCCCEEEEECCCCCHHHCCCCCEEEEECCEEEECCCCCCEECCCCCCCCCCCCCCCHH
VADLFEARRPKELAILAEISGIISFGKETKGKRRLIITPVDGSDAYEEMIPKWRQLNVFE
HHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHCCHHHCCCCCC
GERVERGDVISDGPESPHDILRLRGVQAVTKYIVNEVQEVYRLQGVKINDKHIEVIIRQM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHH
LRKATVIKSGNSEFLDGEQVEFSRIKISNRILNKQSKIPATFSRDLLGITKASLATESFI
HHHHHHHCCCCCCCCCCCCCCHHHEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SAASFQETTRVLTESAVAGKKDELRGLKENVIVGRLIPAGTGYAYHKERLNRRHTVNTNQ
HHHHHHHHHHHHHHHHHCCCHHHHCCHHHCEEEEEEECCCCCCHHHHHHCCCCCCCCCCC
IKPNNSSSQISAEEASASLSELLNSTLIQHDHT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438; 1369199