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The map label for this gene is sdaC [H]

Identifier: 30263357

GI number: 30263357

Start: 3175281

End: 3176600

Strand: Reverse

Name: sdaC [H]

Synonym: BA_3451

Alternate gene names: 30263357

Gene position: 3176600-3175281 (Counterclockwise)

Preceding gene: 30263358

Following gene: 30263355

Centisome position: 60.77

GC content: 35.61

Gene sequence:

>1320_bases
ATGAACGGGAATACTGCAAAGAAAATAGAAGTTCAAGCTGAAAATACCGCACTAAACAATGAGCAATATGCAGATCCGAA
AAAGTGGCATAAGCAGGATACTACATGGGCACTCAGTCTATTTGGAACTGCAATTGGAGCAGGGGTGCTCTTTTTACCGA
TTAATGCAGGTTCAGGTGGTTTATTATCTTTACTACTAATTACATTGCTTGCATATCCAGTTATGTACTACTCACATAGG
GCGCTTGCTAAAATGATATACGCTTCTAATTCTGCTGATGAGGGGATCACAGGTACAATTAGAGAGTATTTCGGAAATAA
AGCGAGTATCATTTTTAACATCGTATATTTCGGTTCAATTTATACAATCGTACTAATGTATTCGGTTGCGCTTACAAACA
CTGCAAGTAGTTTTATCGTGCATCAATTGCACATGCCAGAACCTCCAAGAGCAATTTTATCACTTGTATTAGTTCTTGGT
CTTATCGCTATACTAAATTTTGGTCAAGATATTACTGTAAAGGTAATGAGTATGTTAGTGTATCCTTTCATCGTTTCTCT
ACTGTTTATCGCAATATCTTTAATTCCACAGTGGAATACGTCAATGCTGAGTTTTTCAGCTGTTTCAACTGCTTCAACAG
GAACAGGCTATTTTGGGACGATAGTGATGATTTTACCAATCATCGTATTCTCATTTAATCATTCACCTATGATTTCATCA
TTTGTTGTGAAACAGAGAGCTACGTATGGAATCGAAGCCACTGATGCGAAATGTGCGCAAATACAAAAGGTTTGTTATAT
TATGACATTCGCTGTTGTTATGTTCTTCGTTTGGAGTAGCGCATTGAGCTTGACTCCAGATGATATAAAAATGGCAAAAG
AACAAAACCTATTAATCCTTTCATATCTTGCGAATGAGCTTAATTCACCTGTAATTACGATTGCAGCTCCAATCATTGCT
TTTGTGGCTATTACAAAGTCTTTCCTTGGCCATTATATCGGAGCATTTGAAGTAATGCGTGACATGATTATTAAGTTTGG
TAAATCACGTGGAAAAGATATTGAAGAAAAAACAATTAAGACAATAATCCTTACTTTTGTTGTATTATCATGCTGGTTTG
TTGCTTATACAAATCCAAGTATTCTTGGACTTATTGATTCTCTAAGCGGTCCATTAGTTGCTGCTATCTTATGTCTATTA
CCGATGTATGCGATTCAAAAAGTACCGGTATTAGCTAAGTACAAAGGGAAAATGAGTAACGTATTTGTTATTATTGTAGG
TGTACTTACTGTTTTAGCAAGTATTAAGTCATTATTCTAA

Upstream 100 bases:

>100_bases
TACAATGTGGGGCAACTTGTAAGGAATTCATTTTCCGGAAAGGGAATATTTGTTAGATGCAAAGAGAGATGCAGGAATAG
ATACAAGGGGGAGTTATTAT

Downstream 100 bases:

>100_bases
TTTACGATTGTTGATTTTAGTGTAAAAGTAATGGAATATAAAATATCTATTTTTGGACAAACTTCTCACGTTTGAGAGTT
TGTCCTTTTTATTTCTTCTA

Product: serine/threonine transporter family protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNGNTAKKIEVQAENTALNNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIVSLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTIVMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLLILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Sequences:

>Translated_439_residues
MNGNTAKKIEVQAENTALNNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIVSLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTIVMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLLILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF
>Mature_439_residues
MNGNTAKKIEVQAENTALNNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIVSLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTIVMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLLILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKDIEEKTIKTIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=428, Percent_Identity=50, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=44.1588785046729, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=36.7396593673966, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI145693183, Length=428, Percent_Identity=25.2336448598131, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789961, Length=396, Percent_Identity=23.7373737373737, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48041; Mature: 48041

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGNTAKKIEVQAENTALNNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIVSLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTIVMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
FVVKQRATYGIEATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLLIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKDIEEKTIK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSN
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
VFVIIVGVLTVLASIKSLF
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGNTAKKIEVQAENTALNNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIVSLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTIVMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
FVVKQRATYGIEATDAKCAQIQKVCYIMTFAVVMFFVWSSALSLTPDDIKMAKEQNLLIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKDIEEKTIK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TIILTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSN
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
VFVIIVGVLTVLASIKSLF
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]