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The map label for this gene is qor [C]

Identifier: 30263342

GI number: 30263342

Start: 3158565

End: 3159518

Strand: Reverse

Name: qor [C]

Synonym: BA_3435

Alternate gene names: 30263342

Gene position: 3159518-3158565 (Counterclockwise)

Preceding gene: 30263343

Following gene: 30263341

Centisome position: 60.44

GC content: 39.62

Gene sequence:

>954_bases
ATGAAAGCAATAGGACTTACGCAATATGGAGATAAAAGCGTACTACAAGAGATTGAAATGCAGACACCGCTATTGGGAGA
CAACGATGTACTGATTGAAGTATATGCAGCTGGTGTAAATCCCGTGGATTGGAAAATACGTGAAGGTTTACTGCAAGACG
TAATTTCTTATGACTTCCCGCTCGTTTTAGGATGGGATGTTGCAGGTGTAGTTGCTGCTATAGGAAAAAACGTAACAGTA
TTTAAAGTGGGGGATGAAGTATACAGTCGTCCAGATATTGAACGAAACGGCACGTACGCAGAGTACGTGGCTGTAGATGA
AAAATATGTGGCGAAAAAACCGAGAAATCTATCTTTTGAAGAAGCGGCATCAATCCCTCTAGTAGGTTTGACAAGTTGGC
AAAGCTTAGTGAAGTTCGCAAATGTTCAAAAAGGTAATAAGGTTTTAATTCATGCTGGATCTGGCGGGATTGGAACGTTT
GCTATTCAGCTAGCGAAAAGTTTCGGTGCACATGTTGCAACTACGACTAGTACGAAAAACATGCAATTTGTAAAGGATCT
AGGCGCTGATACTGTCGTCGATTACAAAACGGAAGACTTTTCTTTGCTTTTGCATAATTACAATATTGTATTTGATGTGT
TAGGCGGAGATGTACTAAAGGATAGTTATAAAGTGCTTGCACCAAATGGAAAGTTAGCGTCTATTTATGGTCCGAAAGGT
ATGGAAATTCCGCAAACCGAGATATCAAGAGAGAAAAATATTGAGAGTGACCATATATTTACTGAACCTAACGGATATGA
ACTTTCTCTTATTACAGAATTAATTGAGGGCGGGAAGATTAAACCCGTTGTCACGCATGTGTTGCCTTTACATGTAGAAG
GTGTAAAAAAAGCACACCACATAAGTGAGTCAGAGCGTGCTCGTGGCAAAATAGTATTGAAGAAACATTGGTAA

Upstream 100 bases:

>100_bases
CTTGCTCTATTTGATGGTCAACGTCCAGCTGACGAAGTATTGGATGAGCTAGGAGAAGAAGTACTACCGCATTTCCCAGC
CTTGTAAAGGAGTGAAAAGA

Downstream 100 bases:

>100_bases
AGTATGAGGTTTTAGAGACAGTATTGTGCTAAGTAGCGAATGAGTTTATATATTCTATTCTAGCAATTGTTTTAAAAGGG
AGAGAACAAATGGATTCAAT

Product: alcohol dehydrogenase, zinc-containing

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKAIGLTQYGDKSVLQEIEMQTPLLGDNDVLIEVYAAGVNPVDWKIREGLLQDVISYDFPLVLGWDVAGVVAAIGKNVTV
FKVGDEVYSRPDIERNGTYAEYVAVDEKYVAKKPRNLSFEEAASIPLVGLTSWQSLVKFANVQKGNKVLIHAGSGGIGTF
AIQLAKSFGAHVATTTSTKNMQFVKDLGADTVVDYKTEDFSLLLHNYNIVFDVLGGDVLKDSYKVLAPNGKLASIYGPKG
MEIPQTEISREKNIESDHIFTEPNGYELSLITELIEGGKIKPVVTHVLPLHVEGVKKAHHISESERARGKIVLKKHW

Sequences:

>Translated_317_residues
MKAIGLTQYGDKSVLQEIEMQTPLLGDNDVLIEVYAAGVNPVDWKIREGLLQDVISYDFPLVLGWDVAGVVAAIGKNVTV
FKVGDEVYSRPDIERNGTYAEYVAVDEKYVAKKPRNLSFEEAASIPLVGLTSWQSLVKFANVQKGNKVLIHAGSGGIGTF
AIQLAKSFGAHVATTTSTKNMQFVKDLGADTVVDYKTEDFSLLLHNYNIVFDVLGGDVLKDSYKVLAPNGKLASIYGPKG
MEIPQTEISREKNIESDHIFTEPNGYELSLITELIEGGKIKPVVTHVLPLHVEGVKKAHHISESERARGKIVLKKHW
>Mature_317_residues
MKAIGLTQYGDKSVLQEIEMQTPLLGDNDVLIEVYAAGVNPVDWKIREGLLQDVISYDFPLVLGWDVAGVVAAIGKNVTV
FKVGDEVYSRPDIERNGTYAEYVAVDEKYVAKKPRNLSFEEAASIPLVGLTSWQSLVKFANVQKGNKVLIHAGSGGIGTF
AIQLAKSFGAHVATTTSTKNMQFVKDLGADTVVDYKTEDFSLLLHNYNIVFDVLGGDVLKDSYKVLAPNGKLASIYGPKG
MEIPQTEISREKNIESDHIFTEPNGYELSLITELIEGGKIKPVVTHVLPLHVEGVKKAHHISESERARGKIVLKKHW

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=358, Percent_Identity=31.8435754189944, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI194239674, Length=327, Percent_Identity=31.1926605504587, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI13236495, Length=327, Percent_Identity=31.1926605504587, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI194239676, Length=321, Percent_Identity=31.1526479750779, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI22538446, Length=340, Percent_Identity=29.7058823529412, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI22538444, Length=340, Percent_Identity=29.7058823529412, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24308257, Length=251, Percent_Identity=29.8804780876494, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI18379349, Length=348, Percent_Identity=27.8735632183908, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI28557745, Length=234, Percent_Identity=30.3418803418803, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI90669511, Length=167, Percent_Identity=32.3353293413174, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI67078404, Length=253, Percent_Identity=24.1106719367589, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790485, Length=331, Percent_Identity=28.0966767371601, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17507255, Length=242, Percent_Identity=34.7107438016529, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71987554, Length=341, Percent_Identity=32.258064516129, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562876, Length=342, Percent_Identity=24.8538011695906, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=193, Percent_Identity=27.4611398963731, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=267, Percent_Identity=29.5880149812734, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324195, Length=236, Percent_Identity=27.9661016949153, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=210, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=216, Percent_Identity=26.8518518518519, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319401, Length=169, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=220, Percent_Identity=25.9090909090909, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319945, Length=259, Percent_Identity=27.027027027027, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24581341, Length=242, Percent_Identity=30.9917355371901, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581339, Length=242, Percent_Identity=30.9917355371901, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920632, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330659, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581345, Length=222, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550423, Length=247, Percent_Identity=25.1012145748988, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34807; Mature: 34807

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGLTQYGDKSVLQEIEMQTPLLGDNDVLIEVYAAGVNPVDWKIREGLLQDVISYDFP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
LVLGWDVAGVVAAIGKNVTVFKVGDEVYSRPDIERNGTYAEYVAVDEKYVAKKPRNLSFE
EEECCCHHHHHHHHCCCEEEEEECHHHHCCCCCCCCCCEEEEEEECHHHHHCCCCCCCHH
EAASIPLVGLTSWQSLVKFANVQKGNKVLIHAGSGGIGTFAIQLAKSFGAHVATTTSTKN
HHCCCCEEEHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCC
MQFVKDLGADTVVDYKTEDFSLLLHNYNIVFDVLGGDVLKDSYKVLAPNGKLASIYGPKG
HHHHHHCCCCCEEEECCCCEEEEEECCCEEEEECCCHHHHCCCEEECCCCCEEEEECCCC
MEIPQTEISREKNIESDHIFTEPNGYELSLITELIEGGKIKPVVTHVLPLHVEGVKKAHH
CCCCHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ISESERARGKIVLKKHW
CCCCHHCCCEEEEEECC
>Mature Secondary Structure
MKAIGLTQYGDKSVLQEIEMQTPLLGDNDVLIEVYAAGVNPVDWKIREGLLQDVISYDFP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
LVLGWDVAGVVAAIGKNVTVFKVGDEVYSRPDIERNGTYAEYVAVDEKYVAKKPRNLSFE
EEECCCHHHHHHHHCCCEEEEEECHHHHCCCCCCCCCCEEEEEEECHHHHHCCCCCCCHH
EAASIPLVGLTSWQSLVKFANVQKGNKVLIHAGSGGIGTFAIQLAKSFGAHVATTTSTKN
HHCCCCEEEHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCC
MQFVKDLGADTVVDYKTEDFSLLLHNYNIVFDVLGGDVLKDSYKVLAPNGKLASIYGPKG
HHHHHHCCCCCEEEECCCCEEEEEECCCEEEEECCCHHHHCCCEEECCCCCEEEEECCCC
MEIPQTEISREKNIESDHIFTEPNGYELSLITELIEGGKIKPVVTHVLPLHVEGVKKAHH
CCCCHHHHHHHHCCCCCEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ISESERARGKIVLKKHW
CCCCHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA