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The map label for this gene is yrkA [H]

Identifier: 270000547

GI number: 270000547

Start: 3143203

End: 3144531

Strand: Reverse

Name: yrkA [H]

Synonym: BA_3422

Alternate gene names: 270000547

Gene position: 3144531-3143203 (Counterclockwise)

Preceding gene: 270000546

Following gene: 30263328

Centisome position: 60.16

GC content: 35.74

Gene sequence:

>1329_bases
TTGGAAATATTTAATTTAGTCATGGTTGCGATTTTAATCGCATTTACTGGATTTTTCGTAGCAGCTGAGTTTGCGATTGT
AAAAGTACGTTCAAGTCGTATTGATCAGCTTGTTGCAGAAGGAAAACGCGGTGCTTTAGCAGCGAAAAAGGTAACAACAA
ATTTAGATGAATATTTATCTGCTTGTCAATTAGGTATTACAGTTACAGCTATGGGATTAGGTTGGTTAGGTGAACCGACA
ATTGAAAAGTTATTACACCCGTTATTTGAGAAATGGAACTTAAACCCTTCTATTTCATCAGTATTAACATTTGGTCTTGC
TTTTATGTTAATGACGTATTTACACGTTGTAGTAGGGGAATTAGCTCCTAAAACGATGGCAATTCAAAAGGCTGAAAAAG
TAACATTATTATTTGCAGCTCCACTAATGATGTTCTATAAAGTGATGTATCCATTTATTTGGGTATTAAATGGTTCAGCT
CGTGTGATAACTGGTTTATTCGGTTTAAAACCGGCTTCTGAACATGAAGTAGCTCATACAGAGGAAGAATTACGCCTTAT
TCTTTCAGATAGCTATGAAAGTGGCGAAATTAATCAAGCTGAATACAAGTATGTAAATAACATTTTTGAATTTGATAATC
GTATTGCAAAAGAGATTATGGTACCGCGAACAGAAATCGTTGGTTTCTACCTGGAAGATTCAGTAGAAGAACACATGAAA
GTAATCCAAAATGAGCGATACACACGTTATCCGATTTTTGGAGAAGATAAAGATGATATTATCGGTATGGTCAACGTAAA
AGATTTCTTTATTCGATATATGACCGAGGATCAAAAAGATTTATCATCCATTCGCTCGTATATGCGTCCGATTATTGAAG
TGATGGAAACAACTCCAATTCACGATTTATTACTTCAAATGCAGAAGAAGCGAATTCCGATGGCTGTTTTATATGATGAG
TACGGAGGAACAGCTGGAATTGTAACGTTTGAGGACATCTTGGAGGAAATCGTCGGCGAAATTCGTGATGAATATGATGA
AGATGAAGCACCACCAATTCAACATGTGAACGAGCAACATATCATTGTTGATGGAAAAGTGCTTATCTCAGAAGTGAAAG
ATTTATTTGGATTACACATTGAAGAAGATGATGTGGATACAATCGGTGGATGGATTATGATGCAAAATCATGAAATCGAA
GAAGGACAACACGTTGAGGCGGAAGGTTATGAATTTAAAGTGTTAGAAAAAGACGCTTACCAAATTAAACGTGTTGAAAT
TCGTAAGATGGAAGAGGAACAAGAAGAAGAAAAAGCAGCAACTGTGTAA

Upstream 100 bases:

>100_bases
CTTTAATTTTTGTATCGGGCTATGTTTTCTAAGAAAGAAATAAGAAAACATTATAGTATACAGGAGGTGGACACCTTAGT
TTTTTAACTAAGGGGATTCA

Downstream 100 bases:

>100_bases
GTTGCTGCTTTTCTTCTAAAGTATAAAAAATGAGAAATTAGGAGCGGATATTTTGATTCAAGCAGCCTTACGTGTATATC
GATTACAATTGTATGTGATC

Product: CBS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSA
RVITGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTFEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV

Sequences:

>Translated_442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSA
RVITGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTFEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV
>Mature_442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSA
RVITGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTFEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=404, Percent_Identity=47.7722772277228, Blast_Score=391, Evalue=1e-109,
Organism=Escherichia coli, GI1790664, Length=432, Percent_Identity=23.3796296296296, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI145693175, Length=426, Percent_Identity=25.5868544600939, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786879, Length=255, Percent_Identity=30.1960784313725, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082033, Length=270, Percent_Identity=24.8148148148148, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788119, Length=246, Percent_Identity=25.609756097561, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50620; Mature: 50620

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHH
ACQLGITVTAMGLGWLGEPTIEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGE
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSARVITGLFGLKPASEHEVAHT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCHHCC
EEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPI
HHHCCCCEECCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
HDLLLQMQKKRIPMAVLYDEYGGTAGIVTFEDILEEIVGEIRDEYDEDEAPPIQHVNEQH
HHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCE
IIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIEEGQHVEAEGYEFKVLEKDAY
EEEEHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCHH
QIKRVEIRKMEEEQEEEKAATV
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHH
ACQLGITVTAMGLGWLGEPTIEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGE
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSARVITGLFGLKPASEHEVAHT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCHHCC
EEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPI
HHHCCCCEECCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
HDLLLQMQKKRIPMAVLYDEYGGTAGIVTFEDILEEIVGEIRDEYDEDEAPPIQHVNEQH
HHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCE
IIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIEEGQHVEAEGYEFKVLEKDAY
EEEEHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCHH
QIKRVEIRKMEEEQEEEKAATV
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]