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The map label for this gene is algC [H]

Identifier: 77748747

GI number: 77748747

Start: 4596687

End: 4598081

Strand: Reverse

Name: algC [H]

Synonym: XAC3912

Alternate gene names: 77748747

Gene position: 4598081-4596687 (Counterclockwise)

Preceding gene: 21244632

Following gene: 21244621

Centisome position: 88.84

GC content: 65.09

Gene sequence:

>1395_bases
GTGCAGGTCGCCGCCGGGATGTTTCGTGCCTACGACATCCGCGGCGTGGTCGGCAAAGACCTCAACCCCGGCGTTGCCGC
CTTGATCGGCCAGGCCATCGGCAGCGTGATGCAGGCGCAGGGACTACGCGATGTGGTGGTCGGTCGCGACGGCCGGCTGT
CCGGGCCGGAGCTGAGCAACGGCCTGATCGAAGGCCTGCGCCGTGCCGGCTGCAACGTCACCGACATCGGTCTGGCACCG
ACGCCGGTGGTGTACTTCGGCGCGTACGAGCTGCGTGCCGGCAGCTGCGTGGCGGTGACCGGCAGCCACAATCCACCGGA
CTACAATGGCTTCAAGATCGTGGTCGGCGGCGAGACCTTGTCCGGCGCCGCCATCGCCGAACTGCACCAGCGCATCAACG
AAGGCCGCCTGCATACCGCCGCCACGCCTGGCGAACTGGAACAGCGCGACATCAGCGATGCCTACATCCAGCGCATCGCC
GACGACGTCCAGCTCGATCGCCCGATCAAGGTGGTGGTGGACGCCGGCAATGGCGTGGCCGGTGAGATCGCACCGCGCCT
GCTGGAAGCGATCGGCGCCGACGTGGTGCCGTTGTACTGCGATATCGATGGCACCTTCCCCAACCATCACCCTGATCCGA
GCGAGCCGCACAACCTCAACGATCTGGTGAAGATGGTGCAGCGTTTCGATGCCGATATCGGCGTGGCGTTCGATGGCGAT
GCCGATCGCCTGGGCGTGGTGACCAAGGAAGGCGCGATGGTGTTCCCCGACCGCCTGCTGATGCTGTTCGCCGCCGATGT
ACTGCAGCGCAACCCTGGCGCACTGGTCATCTACGACGTGAAGTGCACCGGCAAGCTGTCCGACTACGTATTGCGCAACG
GCGGCAGTCCGCTGATGTGGAAGACCGGGCATTCGCTGATCAAGTCCAAGATGCGCGAGACCGACGCCGAACTGGCTGGC
GAGATGAGCGGCCACTTCTTCTTCAAGGAGCGCTGGTACGGCTTTGACGACGGCATCTACGCCGCCGCACGCTTGTTGGA
AATCCTGGCCCAGCGCGAGCAGACGCCGTCCGAGGTGCTGGACGCCTTGCCTGAAAGCGTCTCCACGCCGGAGATCAAGG
TGCCGGTGGAAGGCGATGCGCATGCGCTGGTCGCGCAATTTGTCGCGCGTGCGCAGACCGGCGAAGAATCGCCGTTCGAA
TCGGCGCGGCTGTCGACCATCGATGGACTACGTGCGGACTTCATCGACGGCTGGGGGCTGGTACGCGCCTCCAACACCAC
CCCGATCCTGGTGCTGCGGTTCGAAGCCGACAGCGAAGCCGCATTGCAGCGGATTCGCACGCTGTTCCGCAACGAACTGC
AGACGTTGTTGCCGGAGCATTCCGTGGCGTTCTGA

Upstream 100 bases:

>100_bases
CACCTTCAGTCAGAGCCTGCAGCACGACGCCAGCGTTGCCAGCGAAGCACGCGCGCTGGACGCCGAGGCGTCGCCCGCAC
CGCCAGCGCTGGTGCCGGCG

Downstream 100 bases:

>100_bases
TTGCCGGATGCGGAGACCGTCCGCTGCGTTGCCTGTGGAGCGGCAGCGCAGCTGGGCCGGTGCGCGACGCGGCGGTCCGT
CATCCGGTATCGCGTCGGTG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQVAAGMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAP
TPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVVGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIA
DDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGADVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGD
ADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAG
EMSGHFFFKERWYGFDDGIYAAARLLEILAQREQTPSEVLDALPESVSTPEIKVPVEGDAHALVAQFVARAQTGEESPFE
SARLSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHSVAF

Sequences:

>Translated_464_residues
MQVAAGMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAP
TPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVVGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIA
DDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGADVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGD
ADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAG
EMSGHFFFKERWYGFDDGIYAAARLLEILAQREQTPSEVLDALPESVSTPEIKVPVEGDAHALVAQFVARAQTGEESPFE
SARLSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHSVAF
>Mature_464_residues
MQVAAGMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAP
TPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVVGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIA
DDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGADVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGD
ADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAG
EMSGHFFFKERWYGFDDGIYAAARLLEILAQREQTPSEVLDALPESVSTPEIKVPVEGDAHALVAQFVARAQTGEESPFE
SARLSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHSVAF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=464, Percent_Identity=33.1896551724138, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789566, Length=441, Percent_Identity=28.3446712018141, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50067; Mature: 50067

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVAAGMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRDVVVGRDGRLSGPELSN
CCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCHHH
GLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVVGGETL
HHHHHHHHCCCCEEECCCCCCCEEEEECEEECCCCEEEEECCCCCCCCCCEEEEECCCCC
SGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDVQLDRPIKVVVDAGNGVA
CCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GEIAPRLLEAIGADVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGD
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCC
ADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMW
CCCEEEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCCEEE
KTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQREQTPSEVL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
DALPESVSTPEIKVPVEGDAHALVAQFVARAQTGEESPFESARLSTIDGLRADFIDGWGL
HHCHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHCCCCE
VRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHSVAF
EEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQVAAGMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRDVVVGRDGRLSGPELSN
CCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCHHH
GLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVVGGETL
HHHHHHHHCCCCEEECCCCCCCEEEEECEEECCCCEEEEECCCCCCCCCCEEEEECCCCC
SGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDVQLDRPIKVVVDAGNGVA
CCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GEIAPRLLEAIGADVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGD
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCC
ADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMW
CCCEEEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCCEEE
KTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQREQTPSEVL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
DALPESVSTPEIKVPVEGDAHALVAQFVARAQTGEESPFESARLSTIDGLRADFIDGWGL
HHCHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHCCCCE
VRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHSVAF
EEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]