Click here to switch to the map view.

The map label for this gene is yjcE [H]

Identifier: 77748737

GI number: 77748737

Start: 4376069

End: 4377706

Strand: Reverse

Name: yjcE [H]

Synonym: XAC3701

Alternate gene names: 77748737

Gene position: 4377706-4376069 (Counterclockwise)

Preceding gene: 21244429

Following gene: 21244425

Centisome position: 84.58

GC content: 65.2

Gene sequence:

>1638_bases
ATGCATTCGATCGATGTCGTCCTCGCCATGTTGCTGGCGGTCGCGGCCAGCGGTTACCTCATCCGCATCCTGCCGTTTTC
GCTGCCGTTGCCGTTGGTCCAGATCGCCCTGGGCGCGGTGGTCTCCGGCGTTTTCGATGCAGGGCACGAGTTGGAACCGG
AGCTGTTCTTCCTGTTGTTCCTGCCGCCACTGCTGTTCCTGGATGGCTGGCGCATTCCCAAGCAAGGCTTGTTCCGCGAC
AAGGCGGCCATTCTGGAATTGGCGTTGGGGCTGGTCATCTTCACCGTGATTGGCGCCGGCTTCTTCATTCATTGGCTGAT
ACCGGCGATGCCGCTGGCCGTGGCATTCGCGCTGGCGGCGATCATTTCGCCGACCGATCCGGTGGCGGTGTCCTCGATCG
CCTCCAAGGTGCCGATTCCCAAGCGCCTGATGCACATCCTGGAAGGCGAGTCGTTGCTCAACGACGCCTCGGGCCTGGTG
TGTTTCCAGTTCGCGGTGGCGGCGGTGCTGACCGGGACCTTCTCGGTGGCGGCCGCTTCGCTGACCTTTCTGTGGGTGGC
GCTGGCCGGCCTGGCCCTGGGCGTGGCGACGACCTTTGGGTTGAGCCGCATCCAGGCCTGGATCTGGCGGCATTTCGGCG
AGGAGCCCGGTTCGGCGATCCTGGTCAACCTGCTCACCCCATTTGCAGCGTATCTGCTGGCCGAAGCCTTCCACGCGTCC
GGCATCCTGGCCGCAGTGGCCGCTGGCGTCACCATGAGCTATGTGGAAATGGCCGGCAACGCGCCGGGCAACATGCGCCT
GCAGCGGTCGGCGGTGTGGGACACGGTGCAGTTCACCTTCAACGGCATCATCTTCGTGCTGCTGGGCGAGCAGTTGCCGG
GCATCCTGGACGGTGCGGTGCGCAGCGTCCAGGAGGCCGGGCACCTCAATCCGTGGTGGCTGGCGGTGTACGTGGCCACC
ATCAGCGCTAGCTTGATGGCGTTGCGCTTCGTGTGGGTGTTCCTGTCGCTGCGCTGGAACATCTTCAAGGCGCAACGGCG
CGGCGAGGCGCATGTCAGCCCGCCGTGGCGAATCGTGGTGGCGGTATCGTTGGCCGGCGTGCGCGGTGCGATCACCCTGG
CCGGCGTGCTCACGCTGCCATTGATGCTGGAGGACGGCTCGCCATTTCCGGCCCGCCAGTTGGCGATCTTTCTGGCCGCC
TCGGTGATCCTGGTGTCGCTGCTGGTGGCCAGCGTCGCGTTGCCGCGCCTGTTGCGCGGTCTGGAACTGCCCGAGGAAGA
AGACGAGCAACTCAAGGAAGACCTAGCCGTGAAGGCCGCTTCGCAGGCGGCGCTGGAGGCAGTGGAAAAACTGCGCCAGC
GGCTGGTGGACGGCAGCAAGCATGCCGAGCGCTACAACGCAGCGGCCAACCAGGTGAGCCAGCGCTATCAGCGCAAGCTC
GGCGCGGTGGACATGGCCGAGACCGATCCGGAAGAGGCGGTTGCCTACGAAAAGGCGCTGCGTCAGTTCCGCCATGCGGC
ATTGGTGGCCGAGCGCAATGAGTTGTTCAAGCTTGCGCGACGACGCGAGATTTCCGACGACCTGTCGCGACGGCTGGTGC
GCAACCTGGATCTGATCGAGTCGCGCAAGCGCGCTTGA

Upstream 100 bases:

>100_bases
CCCGGGTGCAACACGGTATGGTCCGGTAGGTGCGTTGTTGTTGTGCGTCGCAATATGCGATGCCGCACGTGCGGCCGCTT
TTTTTCATTCCGGGTTTTTC

Downstream 100 bases:

>100_bases
GCGCGCTGATGCGCGCGGTAATCGGGAATCGGGATTGGGGAATCGCAAGAGCCACGGCGGTTGCCGTGTTTGGGTAGGAG
CGCACCTGAGCGCGATGGGG

Product: Na+:H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGVTMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISASLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVDGSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA

Sequences:

>Translated_545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGVTMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISASLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVDGSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA
>Mature_545_residues
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLFLPPLLFLDGWRIPKQGLFRD
KAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAAIISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLV
CFQFAVAAVLTGTFSVAAASLTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
GILAAVAAGVTMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAVRSVQEAGHLNPWWLAVYVAT
ISASLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVVAVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAA
SVILVSLLVASVALPRLLRGLELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVDGSKHAERYNAAANQVSQRYQRKL
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIESRKRA

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=506, Percent_Identity=22.9249011857708, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI15529998, Length=583, Percent_Identity=24.0137221269297, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI27777632, Length=514, Percent_Identity=25.6809338521401, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI41872703, Length=428, Percent_Identity=26.4018691588785, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI4759144, Length=257, Percent_Identity=31.9066147859922, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI27734935, Length=412, Percent_Identity=23.5436893203883, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI194239733, Length=453, Percent_Identity=24.5033112582781, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI110227626, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI294997330, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI14211919, Length=416, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI5454070, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790501, Length=544, Percent_Identity=41.9117647058824, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71987559, Length=437, Percent_Identity=24.7139588100687, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71987545, Length=437, Percent_Identity=24.7139588100687, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=474, Percent_Identity=23.6286919831224, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=531, Percent_Identity=23.1638418079096, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=404, Percent_Identity=26.4851485148515, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993582, Length=404, Percent_Identity=26.4851485148515, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=494, Percent_Identity=21.6599190283401, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71999817, Length=525, Percent_Identity=21.3333333333333, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71999819, Length=525, Percent_Identity=21.3333333333333, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25147678, Length=404, Percent_Identity=23.7623762376238, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987535, Length=523, Percent_Identity=22.5621414913958, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=523, Percent_Identity=22.3709369024857, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=339, Percent_Identity=23.3038348082596, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992107, Length=339, Percent_Identity=23.3038348082596, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510738, Length=421, Percent_Identity=24.9406175771971, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI221510734, Length=421, Percent_Identity=24.9406175771971, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI221510732, Length=428, Percent_Identity=26.1682242990654, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510736, Length=428, Percent_Identity=26.1682242990654, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585580, Length=428, Percent_Identity=25.7009345794392, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585578, Length=428, Percent_Identity=25.7009345794392, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510740, Length=428, Percent_Identity=25.7009345794392, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360447, Length=504, Percent_Identity=24.0079365079365, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221473222, Length=434, Percent_Identity=24.1935483870968, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281364513, Length=439, Percent_Identity=24.1457858769932, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221473212, Length=407, Percent_Identity=24.5700245700246, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221473215, Length=439, Percent_Identity=24.373576309795, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59173; Mature: 59173

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPPLLFLDGWRIPKQGLFRDKAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLVCFQFAVAAVLTGTFSVAAAS
HHCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGVTMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
RSVQEAGHLNPWWLAVYVATISASLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAASVILVSLLVASVALPRLLRG
EEHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVDGSKHAERYNAAANQVSQRYQRKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKRA
HCCCC
>Mature Secondary Structure
MHSIDVVLAMLLAVAASGYLIRILPFSLPLPLVQIALGAVVSGVFDAGHELEPELFFLLF
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPPLLFLDGWRIPKQGLFRDKAAILELALGLVIFTVIGAGFFIHWLIPAMPLAVAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISPTDPVAVSSIASKVPIPKRLMHILEGESLLNDASGLVCFQFAVAAVLTGTFSVAAAS
HHCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTFLWVALAGLALGVATTFGLSRIQAWIWRHFGEEPGSAILVNLLTPFAAYLLAEAFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILAAVAAGVTMSYVEMAGNAPGNMRLQRSAVWDTVQFTFNGIIFVLLGEQLPGILDGAV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
RSVQEAGHLNPWWLAVYVATISASLMALRFVWVFLSLRWNIFKAQRRGEAHVSPPWRIVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLMLEDGSPFPARQLAIFLAASVILVSLLVASVALPRLLRG
EEHHHCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LELPEEEDEQLKEDLAVKAASQAALEAVEKLRQRLVDGSKHAERYNAAANQVSQRYQRKL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GAVDMAETDPEEAVAYEKALRQFRHAALVAERNELFKLARRREISDDLSRRLVRNLDLIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKRA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]