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The map label for this gene is purM [H]

Identifier: 77748683

GI number: 77748683

Start: 3464629

End: 3465687

Strand: Direct

Name: purM [H]

Synonym: XAC2959

Alternate gene names: 77748683

Gene position: 3464629-3465687 (Clockwise)

Preceding gene: 21243682

Following gene: 21243687

Centisome position: 66.94

GC content: 67.04

Gene sequence:

>1059_bases
GTGACCAGCCAGACGCCTTCCAGCCCCTCGCCCATGACCTACCGCGACGCGGGGGTCGACATCGACGCCGGCAATGCATT
GGTCGAACGCATCAAGCCGCTGGTCAAGCGCAGCTTCCGGCCCGAGGTCATGGGCGGCCTGGGCGGCTTCGGGGCGCTGT
TCGACCTGTCCGGCAAGTACAAGGAGCCGGTCCTGGTGTCCGGCACCGACGGCGTGGGCACCAAGCTCAAGCTGGCCCAG
CAGTTGGGGCGGCACGACACCATCGGCATCGATCTGGTCGGCATGTGCGTCAACGACGTGCTGGTGCAGGGCGCCGAGCC
GTTGTTCTTCCTGGATTACTTCGCCACCGGCAAGCTGGACGTGGATACCGCTGCGGCGGTGGTGGGCGGCATCGCACGCG
GCTGCGAGCTTTCCGGTTGCGCGCTGATCGGCGGCGAGACCGCTGAAATGCCCGACATGTATCCGCCGGGCGAATACGAC
CTGGCCGGCTTCACCGTGGGTGCGGTGGAAAAGTCGCAGCTGCTGGATGGCGCACAGGTGCGCGAAGGCGACGTGCTGAT
CGGCATCGCCTCCTCCGGCCCGCATTCCAACGGCTATTCGTTGATCCGCAAGATCTACGAGCGCGCCGGCGCGCCGGCCG
AACACGTACTGGACGATGGCACCAAGCTGATCGATGCGCTGATGGCGCCAACCGCGCTGTACGTCAAGCCGGTGCTGGCG
CTGCTGAAGTCGCACGGTGAAGCGATCCACGCGATGGCGCATATCACCGGTGGCGGCCTCACCGAAAACATCATCCGCGT
GATACCCGAAGGCCTGGGTCTGGAGATCGACGCCACTGCCTGGACCCTGCCGCCGGTATTCGCCTGGCTGCAGCGCGAAG
GTGCGGTGGCCGATGCCGAAATGTGGCGCACCTTCAACTGCGGAATCGGCTTCGTGCTGGTTGCCGCGCCCGCGCAGGCG
GCCGCGCTGGAACAGGCGTTGGATGCGCAGTCGCTGGCGCATTGGCGCATCGGCCAGGTGGTGACGGCGCATGGCGACGA
GCGCGTGCGCATCGGCTGA

Upstream 100 bases:

>100_bases
ATGACATAAGCGTATCCGGGTGAATTGTTGCCCGAATGGGGCGCTAGCGCCAACGTGGCTGCTAAAATCGCCGCCTTATA
CCGCCGAGCCACCCCCGCCC

Downstream 100 bases:

>100_bases
TCGATCAGGACACCCGCATGGACGCTTTTCCAGTCGCCACGACCGCATCGGCCAGCACCGACGATCTGCAGCATCTCAAG
CTGCTGTCGATCTTCCACTA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTSQTPSSPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQ
QLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDVDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYD
LAGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGAPAEHVLDDGTKLIDALMAPTALYVKPVLA
LLKSHGEAIHAMAHITGGGLTENIIRVIPEGLGLEIDATAWTLPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQA
AALEQALDAQSLAHWRIGQVVTAHGDERVRIG

Sequences:

>Translated_352_residues
MTSQTPSSPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQ
QLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDVDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYD
LAGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGAPAEHVLDDGTKLIDALMAPTALYVKPVLA
LLKSHGEAIHAMAHITGGGLTENIIRVIPEGLGLEIDATAWTLPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQA
AALEQALDAQSLAHWRIGQVVTAHGDERVRIG
>Mature_351_residues
TSQTPSSPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKYKEPVLVSGTDGVGTKLKLAQQ
LGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLDVDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDL
AGFTVGAVEKSQLLDGAQVREGDVLIGIASSGPHSNGYSLIRKIYERAGAPAEHVLDDGTKLIDALMAPTALYVKPVLAL
LKSHGEAIHAMAHITGGGLTENIIRVIPEGLGLEIDATAWTLPPVFAWLQREGAVADAEMWRTFNCGIGFVLVAAPAQAA
ALEQALDAQSLAHWRIGQVVTAHGDERVRIG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=54.8571428571429, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=54.8571428571429, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=54.8571428571429, Blast_Score=371, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=59.8265895953757, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567511, Length=355, Percent_Identity=41.6901408450704, Blast_Score=255, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=46.8023255813954, Blast_Score=306, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24582400, Length=269, Percent_Identity=46.8401486988848, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36972; Mature: 36841

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQTPSSPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKY
CCCCCCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHEECCCCC
KEPVLVSGTDGVGTKLKLAQQLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLD
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
VDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDLAGFTVGAVEKSQLLDGAQV
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCC
REGDVLIGIASSGPHSNGYSLIRKIYERAGAPAEHVLDDGTKLIDALMAPTALYVKPVLA
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLKSHGEAIHAMAHITGGGLTENIIRVIPEGLGLEIDATAWTLPPVFAWLQREGAVADAE
HHHHCCHHEEHHHHHCCCCHHHHHHHHCCCCCCEEECCCEECHHHHHHHHHHCCCCCHHH
MWRTFNCGIGFVLVAAPAQAAALEQALDAQSLAHWRIGQVVTAHGDERVRIG
HHEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEEECC
>Mature Secondary Structure 
TSQTPSSPSPMTYRDAGVDIDAGNALVERIKPLVKRSFRPEVMGGLGGFGALFDLSGKY
CCCCCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHEECCCCC
KEPVLVSGTDGVGTKLKLAQQLGRHDTIGIDLVGMCVNDVLVQGAEPLFFLDYFATGKLD
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
VDTAAAVVGGIARGCELSGCALIGGETAEMPDMYPPGEYDLAGFTVGAVEKSQLLDGAQV
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCC
REGDVLIGIASSGPHSNGYSLIRKIYERAGAPAEHVLDDGTKLIDALMAPTALYVKPVLA
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLKSHGEAIHAMAHITGGGLTENIIRVIPEGLGLEIDATAWTLPPVFAWLQREGAVADAE
HHHHCCHHEEHHHHHCCCCHHHHHHHHCCCCCCEEECCCEECHHHHHHHHHHCCCCCHHH
MWRTFNCGIGFVLVAAPAQAAALEQALDAQSLAHWRIGQVVTAHGDERVRIG
HHEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]