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The map label for this gene is ptpA [H]

Identifier: 77748537

GI number: 77748537

Start: 692208

End: 694520

Strand: Reverse

Name: ptpA [H]

Synonym: XAC0591

Alternate gene names: 77748537

Gene position: 694520-692208 (Counterclockwise)

Preceding gene: 21241363

Following gene: 21241360

Centisome position: 13.42

GC content: 64.55

Gene sequence:

>2313_bases
TTGCCGCTGCGGCACCTGTGCATCGTCGTCGCCCTGGCCGCTCTGCCGGCACTTGCCAGCGCGCAAGCCCCTGCCGTCAC
CGAGGCCGACTACGCGCGCGCCGAACGGCTGATCAACTACGCCGCACAGCCGCTGGTGGACCACGCCGTCACCCGCATCG
ACTGGCTGGACGCCACGCACGTGGCGTATGTCGATCACGATGCCAAGGGCAACCGGCTGCTGCAGCTGGACACCAGCACC
GGCAAGACCGCACCGCTCTTCAAACAGGCTGCACTGGTGGCTTCGCTCAACACGCTATTGAAGACCGGCGACAAGCCGCT
CAAGGCCGACACCTTCGCGCCGATGGTCAAGGTCACCGCCGATGGTCGCTACCGCCTCAACGTGCGCGATACCGCCGTGG
TCTGCGATGCGCGTGCGCGTTGCAGCAAGCTGTACGCCAAGGACAAACCGGAACCGGGCGTGCTGTCGCCGGACAAGCGC
AGCGAAGCCTTCATCCGCGACTGGAACCTGTGGGTACGCGATCTTGCCGGCGGCCAGGAAACCCAGCTCACCCGCGATGG
CGTGGAAAACTTCGGTTACGCCACCGACAACGCCGGCTGGCAGCACACCGACAATGCCATCGTGGCGTGGTCGCCGGACT
CCCGCAAGATCGCCACCTTCCAGCAGGACCAGCGCAAGACCGGCGACATGTACCTGGTCAGCACCAAGCTTGGGCATCCG
GAGCTGCAGGCGTGGAAATATCCGCTGGCCGGCGACAAGGACGTGACCATGATCGAGCGCGTCATCATCGACGTGCCCAC
CCGCAGCGTGCTGCGCCTGAAGACACCGCCGGACCAACATCGCTCCACGCTCTGCGACGACGTAAGTTGCTCGCCTGGCC
TGTGGGACGACGAGAAGTGGGCACCGGACAGCAAGACGCTGGCGTTCGCCTCCACCTCGCGCTTCCACAAGCAGACCTGG
TTGCGCATTGCCGATGCCAGCACGGGCGCGGTGCGTACCGCCTTCGATGAAACCGTCAAAACCTATTACGAAAGCGGCCA
GGTCGCGGCCAATTGGGCCTATCTGCCGGCCAGCAACGAGGCGGTGTGGTTCTCCGAACGCAGCGATTGGGGCCAGCTGT
ATCTCTACGATCTGGCCACCGGCAAACCCAAGCGCGCCATCACCACCGGCCAAGGCAACGTCACCGAATTGCTGCGCGTG
GACCCGGTCACGCGCACCGCATGGTTTGTCGGCGTCGGCCGCAGCGCAGGCGTGGACCCGTACTACCAGCAGCTGTGGAA
AGTCAGCCTGGATGGCGGCGAGCCGGTGTTGCTCACGCCGGAACCGGCCAACCACAGCATCGCGCTGTCGCCCGATGGCG
CACGTTTTGTCGACACCTATTCCACCTCGGTCACGCCGCCGGTCACGTTGCTGCGCGAAGCCGGCGACGGCCGCACTGTG
AGCACGATGGCCACCGCCGATATCACGCGTCTCAAGGCGGCCGGCTGGGTTCCGCCAGAACCCATCACGGTGAAGGCACG
CGATGGCAAGACCACGCTGTACGGGTTGATGTTCAAGCCCACCAACTTCGACCCGGCGCGCAAGTATCCGGTCATCGATT
ACGTCTACCCCGGCCCGCAGACCGGCTCGGTGCGCGGGCGTAGCTTTCTCGCCGGACATGGCGACAACCAGTCGCTGGCC
GAACTGGGCTTTATTGTGATTGCCATCGATGGCATGGGCACGCCGTGGCGCTCCAAGAGTTTCCACGACACCTGGTACGC
CGACATGGGCGACAACACCTTGCCCGATCAGGTCGCCGGCTTGAAGGAGCTTGGTCAGCGCTATCCCTGGATCGATCTGG
GTCGCGTCGGCATCTGGGGCCATTCCGGCGGCGGCAACGCCTCGACCGGCGCGATGCTGCGCTATCCGGATTTCTTCAAG
GTCGCCTGGTCGGAAAGCGGCAACCACGACAATCGCGGCTACGAAGACGACTGGGCCGAGAAATATCACGGCGAGCACAT
CGTCAACAAGGACGGTACCTCCAACTACGACGACCAGGCCAACGCCAACCACGCCAGCAAGCTCAAGGGCCGGCTGATGC
TGGTGCACGGCACCCTGGACGACAACGTGCCGCCGTACCTCACCTTGCTGGTGGCCGATGCCTTGATCAAGGCCAACAAG
AACTTCGACATGCTGATGCTGCCCAACGCCAAGCATGGCTACGGCGATCTCACCCCGTACGTCACCCGCCGCCGCTGGGA
TTACTTCGTGCAATATCTGCTCGGTGCGACCCCGCCGGCGCAGTATCAGATGCAGCCGATGCCGGCGAATTGA

Upstream 100 bases:

>100_bases
GCAGAGGCACCCGGCCCGCGTGGCGGGTAGCATCGGACGGTCGCGCCGACCGCATTGCGCGCTCCTTTCATCCCGGAGAG
TCTTCATGCCCACCATCCCG

Downstream 100 bases:

>100_bases
GCCAGGTGCAGGCGGTGCGGTGGCCGATGCGGCGCCATGTCCGCGGCTGACGATTCGCCGCGTCAAGCTGCCGGATCACA
CGTGTCATCCGGCCAGGCCC

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MPLRHLCIVVALAALPALASAQAPAVTEADYARAERLINYAAQPLVDHAVTRIDWLDATHVAYVDHDAKGNRLLQLDTST
GKTAPLFKQAALVASLNTLLKTGDKPLKADTFAPMVKVTADGRYRLNVRDTAVVCDARARCSKLYAKDKPEPGVLSPDKR
SEAFIRDWNLWVRDLAGGQETQLTRDGVENFGYATDNAGWQHTDNAIVAWSPDSRKIATFQQDQRKTGDMYLVSTKLGHP
ELQAWKYPLAGDKDVTMIERVIIDVPTRSVLRLKTPPDQHRSTLCDDVSCSPGLWDDEKWAPDSKTLAFASTSRFHKQTW
LRIADASTGAVRTAFDETVKTYYESGQVAANWAYLPASNEAVWFSERSDWGQLYLYDLATGKPKRAITTGQGNVTELLRV
DPVTRTAWFVGVGRSAGVDPYYQQLWKVSLDGGEPVLLTPEPANHSIALSPDGARFVDTYSTSVTPPVTLLREAGDGRTV
STMATADITRLKAAGWVPPEPITVKARDGKTTLYGLMFKPTNFDPARKYPVIDYVYPGPQTGSVRGRSFLAGHGDNQSLA
ELGFIVIAIDGMGTPWRSKSFHDTWYADMGDNTLPDQVAGLKELGQRYPWIDLGRVGIWGHSGGGNASTGAMLRYPDFFK
VAWSESGNHDNRGYEDDWAEKYHGEHIVNKDGTSNYDDQANANHASKLKGRLMLVHGTLDDNVPPYLTLLVADALIKANK
NFDMLMLPNAKHGYGDLTPYVTRRRWDYFVQYLLGATPPAQYQMQPMPAN

Sequences:

>Translated_770_residues
MPLRHLCIVVALAALPALASAQAPAVTEADYARAERLINYAAQPLVDHAVTRIDWLDATHVAYVDHDAKGNRLLQLDTST
GKTAPLFKQAALVASLNTLLKTGDKPLKADTFAPMVKVTADGRYRLNVRDTAVVCDARARCSKLYAKDKPEPGVLSPDKR
SEAFIRDWNLWVRDLAGGQETQLTRDGVENFGYATDNAGWQHTDNAIVAWSPDSRKIATFQQDQRKTGDMYLVSTKLGHP
ELQAWKYPLAGDKDVTMIERVIIDVPTRSVLRLKTPPDQHRSTLCDDVSCSPGLWDDEKWAPDSKTLAFASTSRFHKQTW
LRIADASTGAVRTAFDETVKTYYESGQVAANWAYLPASNEAVWFSERSDWGQLYLYDLATGKPKRAITTGQGNVTELLRV
DPVTRTAWFVGVGRSAGVDPYYQQLWKVSLDGGEPVLLTPEPANHSIALSPDGARFVDTYSTSVTPPVTLLREAGDGRTV
STMATADITRLKAAGWVPPEPITVKARDGKTTLYGLMFKPTNFDPARKYPVIDYVYPGPQTGSVRGRSFLAGHGDNQSLA
ELGFIVIAIDGMGTPWRSKSFHDTWYADMGDNTLPDQVAGLKELGQRYPWIDLGRVGIWGHSGGGNASTGAMLRYPDFFK
VAWSESGNHDNRGYEDDWAEKYHGEHIVNKDGTSNYDDQANANHASKLKGRLMLVHGTLDDNVPPYLTLLVADALIKANK
NFDMLMLPNAKHGYGDLTPYVTRRRWDYFVQYLLGATPPAQYQMQPMPAN
>Mature_769_residues
PLRHLCIVVALAALPALASAQAPAVTEADYARAERLINYAAQPLVDHAVTRIDWLDATHVAYVDHDAKGNRLLQLDTSTG
KTAPLFKQAALVASLNTLLKTGDKPLKADTFAPMVKVTADGRYRLNVRDTAVVCDARARCSKLYAKDKPEPGVLSPDKRS
EAFIRDWNLWVRDLAGGQETQLTRDGVENFGYATDNAGWQHTDNAIVAWSPDSRKIATFQQDQRKTGDMYLVSTKLGHPE
LQAWKYPLAGDKDVTMIERVIIDVPTRSVLRLKTPPDQHRSTLCDDVSCSPGLWDDEKWAPDSKTLAFASTSRFHKQTWL
RIADASTGAVRTAFDETVKTYYESGQVAANWAYLPASNEAVWFSERSDWGQLYLYDLATGKPKRAITTGQGNVTELLRVD
PVTRTAWFVGVGRSAGVDPYYQQLWKVSLDGGEPVLLTPEPANHSIALSPDGARFVDTYSTSVTPPVTLLREAGDGRTVS
TMATADITRLKAAGWVPPEPITVKARDGKTTLYGLMFKPTNFDPARKYPVIDYVYPGPQTGSVRGRSFLAGHGDNQSLAE
LGFIVIAIDGMGTPWRSKSFHDTWYADMGDNTLPDQVAGLKELGQRYPWIDLGRVGIWGHSGGGNASTGAMLRYPDFFKV
AWSESGNHDNRGYEDDWAEKYHGEHIVNKDGTSNYDDQANANHASKLKGRLMLVHGTLDDNVPPYLTLLVADALIKANKN
FDMLMLPNAKHGYGDLTPYVTRRRWDYFVQYLLGATPPAQYQMQPMPAN

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=362, Percent_Identity=31.767955801105, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI18450280, Length=362, Percent_Identity=31.767955801105, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI194394146, Length=369, Percent_Identity=30.8943089430894, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI37577091, Length=363, Percent_Identity=25.6198347107438, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI16933540, Length=364, Percent_Identity=24.4505494505494, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI18450278, Length=172, Percent_Identity=30.8139534883721, Blast_Score=70, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508017, Length=345, Percent_Identity=29.2753623188406, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17508019, Length=348, Percent_Identity=29.8850574712644, Blast_Score=121, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17564632, Length=490, Percent_Identity=23.0612244897959, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17564634, Length=490, Percent_Identity=23.0612244897959, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324793, Length=221, Percent_Identity=29.8642533936652, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321817, Length=220, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550825, Length=390, Percent_Identity=28.7179487179487, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45553511, Length=390, Percent_Identity=28.7179487179487, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551969, Length=390, Percent_Identity=28.7179487179487, Blast_Score=123, Evalue=5e-28,
Organism=Drosophila melanogaster, GI221331178, Length=255, Percent_Identity=30.5882352941176, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17933704, Length=262, Percent_Identity=30.5343511450382, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161083744, Length=262, Percent_Identity=30.5343511450382, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24582257, Length=243, Percent_Identity=25.5144032921811, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24582032, Length=230, Percent_Identity=27.3913043478261, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 85173; Mature: 85041

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRHLCIVVALAALPALASAQAPAVTEADYARAERLINYAAQPLVDHAVTRIDWLDATH
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCE
VAYVDHDAKGNRLLQLDTSTGKTAPLFKQAALVASLNTLLKTGDKPLKADTFAPMVKVTA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
DGRYRLNVRDTAVVCDARARCSKLYAKDKPEPGVLSPDKRSEAFIRDWNLWVRDLAGGQE
CCEEEEEECCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
TQLTRDGVENFGYATDNAGWQHTDNAIVAWSPDSRKIATFQQDQRKTGDMYLVSTKLGHP
HHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCCCEEEHHHHHHCCCCCEEEEEECCCCC
ELQAWKYPLAGDKDVTMIERVIIDVPTRSVLRLKTPPDQHRSTLCDDVSCSPGLWDDEKW
CHHHEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCC
APDSKTLAFASTSRFHKQTWLRIADASTGAVRTAFDETVKTYYESGQVAANWAYLPASNE
CCCCCEEEEEHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
AVWFSERSDWGQLYLYDLATGKPKRAITTGQGNVTELLRVDPVTRTAWFVGVGRSAGVDP
EEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCEEHEEECCCCCEEEEEECCCCCCCCH
YYQQLWKVSLDGGEPVLLTPEPANHSIALSPDGARFVDTYSTSVTPPVTLLREAGDGRTV
HHHHHEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCEE
STMATADITRLKAAGWVPPEPITVKARDGKTTLYGLMFKPTNFDPARKYPVIDYVYPGPQ
EEEHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCC
TGSVRGRSFLAGHGDNQSLAELGFIVIAIDGMGTPWRSKSFHDTWYADMGDNTLPDQVAG
CCCCCCCEEEECCCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHH
LKELGQRYPWIDLGRVGIWGHSGGGNASTGAMLRYPDFFKVAWSESGNHDNRGYEDDWAE
HHHHHHHCCCEEECCEEEEECCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCHHHH
KYHGEHIVNKDGTSNYDDQANANHASKLKGRLMLVHGTLDDNVPPYLTLLVADALIKANK
HHCCCEEECCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCC
NFDMLMLPNAKHGYGDLTPYVTRRRWDYFVQYLLGATPPAQYQMQPMPAN
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCC
>Mature Secondary Structure 
PLRHLCIVVALAALPALASAQAPAVTEADYARAERLINYAAQPLVDHAVTRIDWLDATH
CHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCE
VAYVDHDAKGNRLLQLDTSTGKTAPLFKQAALVASLNTLLKTGDKPLKADTFAPMVKVTA
EEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
DGRYRLNVRDTAVVCDARARCSKLYAKDKPEPGVLSPDKRSEAFIRDWNLWVRDLAGGQE
CCEEEEEECCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
TQLTRDGVENFGYATDNAGWQHTDNAIVAWSPDSRKIATFQQDQRKTGDMYLVSTKLGHP
HHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCCCEEEHHHHHHCCCCCEEEEEECCCCC
ELQAWKYPLAGDKDVTMIERVIIDVPTRSVLRLKTPPDQHRSTLCDDVSCSPGLWDDEKW
CHHHEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCC
APDSKTLAFASTSRFHKQTWLRIADASTGAVRTAFDETVKTYYESGQVAANWAYLPASNE
CCCCCEEEEEHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
AVWFSERSDWGQLYLYDLATGKPKRAITTGQGNVTELLRVDPVTRTAWFVGVGRSAGVDP
EEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCEEHEEECCCCCEEEEEECCCCCCCCH
YYQQLWKVSLDGGEPVLLTPEPANHSIALSPDGARFVDTYSTSVTPPVTLLREAGDGRTV
HHHHHEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCEE
STMATADITRLKAAGWVPPEPITVKARDGKTTLYGLMFKPTNFDPARKYPVIDYVYPGPQ
EEEHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCC
TGSVRGRSFLAGHGDNQSLAELGFIVIAIDGMGTPWRSKSFHDTWYADMGDNTLPDQVAG
CCCCCCCEEEECCCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHH
LKELGQRYPWIDLGRVGIWGHSGGGNASTGAMLRYPDFFKVAWSESGNHDNRGYEDDWAE
HHHHHHHCCCEEECCEEEEECCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCHHHH
KYHGEHIVNKDGTSNYDDQANANHASKLKGRLMLVHGTLDDNVPPYLTLLVADALIKANK
HHCCCEEECCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCC
NFDMLMLPNAKHGYGDLTPYVTRRRWDYFVQYLLGATPPAQYQMQPMPAN
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA