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The map label for this gene is ble [H]

Identifier: 21244950

GI number: 21244950

Start: 4998824

End: 4999213

Strand: Reverse

Name: ble [H]

Synonym: XAC4233

Alternate gene names: 21244950

Gene position: 4999213-4998824 (Counterclockwise)

Preceding gene: 21244951

Following gene: 77748766

Centisome position: 96.59

GC content: 62.31

Gene sequence:

>390_bases
ATGGACACCAGCATCAACATAGAGGCGCAAACCATCCCAACCCTGCCAAGCCGCTCGATTCCGCAGACGGTGGCGTTCTA
TCGGCAACTGGGCTTTGTCGGCGATGCGCATCCGCACGATGCAGGTTACGCAATCCTGCGACGTGGCGATGTGGAGCTGC
ACTTCTTCGCGCATCCGGATCTGGATCCGGCCGACTGTTATGCGGGCTGTTACATCAGGGTCGGCGATGTGGATGCCGTC
CACGCAGCGATGCAGCTCACCGCCTTGCCCGAGCGAGGCATTCCACGGCTCGACCCGGTCGGCGACAAGCCCTGGGGCAT
GCGTGAGTTCGCCATCGTCGATGAGAGCGGCAATCTGCTGCGGATTGGGCAGGTGATCGCGTCAGGGTGA

Upstream 100 bases:

>100_bases
GCCCGCTAGCGCTTTTGAGGCGCGTGTACGAGCGAGCCTGTCACTTCCATCGAGCTGCGCACATGAGCGCTTCTGAAACG
TGGACCCATGGAGATTGGTA

Downstream 100 bases:

>100_bases
TGCATTGCATGAGCAAGGCGACTGCGCTGCTCACCGACCTGATGGCGCCCGCCCGCGCAATGCATGGCGCTGTGCACCGT
CTTACACCTCACCCATCGAC

Product: bleomycin resistance protein

Products: NA

Alternate protein names: BRP; CL990 resistance protein [H]

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MDTSINIEAQTIPTLPSRSIPQTVAFYRQLGFVGDAHPHDAGYAILRRGDVELHFFAHPDLDPADCYAGCYIRVGDVDAV
HAAMQLTALPERGIPRLDPVGDKPWGMREFAIVDESGNLLRIGQVIASG

Sequences:

>Translated_129_residues
MDTSINIEAQTIPTLPSRSIPQTVAFYRQLGFVGDAHPHDAGYAILRRGDVELHFFAHPDLDPADCYAGCYIRVGDVDAV
HAAMQLTALPERGIPRLDPVGDKPWGMREFAIVDESGNLLRIGQVIASG
>Mature_129_residues
MDTSINIEAQTIPTLPSRSIPQTVAFYRQLGFVGDAHPHDAGYAILRRGDVELHFFAHPDLDPADCYAGCYIRVGDVDAV
HAAMQLTALPERGIPRLDPVGDKPWGMREFAIVDESGNLLRIGQVIASG

Specific function: Binding protein with a strong affinity to the bleomycin family of antibiotics. Binds to CL990; an antimitotic-antibiotic compound [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bleomycin resistance protein family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000335 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 14055; Mature: 14055

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSINIEAQTIPTLPSRSIPQTVAFYRQLGFVGDAHPHDAGYAILRRGDVELHFFAHPD
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCC
LDPADCYAGCYIRVGDVDAVHAAMQLTALPERGIPRLDPVGDKPWGMREFAIVDESGNLL
CCHHHHCCCCEEEECCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
RIGQVIASG
EEEEEECCC
>Mature Secondary Structure
MDTSINIEAQTIPTLPSRSIPQTVAFYRQLGFVGDAHPHDAGYAILRRGDVELHFFAHPD
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCC
LDPADCYAGCYIRVGDVDAVHAAMQLTALPERGIPRLDPVGDKPWGMREFAIVDESGNLL
CCHHHHCCCCEEEECCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
RIGQVIASG
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3889831 [H]