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The map label for this gene is desK [H]

Identifier: 21244712

GI number: 21244712

Start: 4685234

End: 4686511

Strand: Reverse

Name: desK [H]

Synonym: XAC3994

Alternate gene names: 21244712

Gene position: 4686511-4685234 (Counterclockwise)

Preceding gene: 77748749

Following gene: 21244711

Centisome position: 90.55

GC content: 68.31

Gene sequence:

>1278_bases
ATGCATGAGGCCGCTCACCCCTATCGTCCCGCACGCAGCGGCACGCAGACGGGCCCGGCAGTGGCAGAATCCGCTCACCC
ACACGGATCTTCGCTGATGCGCCTCCGGTTTCCCGCATGGCTTCGTCCCGCCGCCAGTTCGCAGGTTGCCGCGCGGCTGG
CGCAGGGGCAATCGCCGTGGATGGATAGCGTGCACCTGTTTTGGTCGGCCTGGGTGTTCGTAGTGCCGGCGTTTTCTGCG
CGTGGCTACGACAGCACCTGGCTGTTGTGCACGCTGGCGTCTTATCCGGTGTTTGTGCTGCTCTACGCACGCATGTTGCT
GGCGCCGCGCGGCACCTTGTACCGCTACGCCTGGGCGATGGCGGCGCTGAGTGCTGCCTTGCTGCCGGTGTACTCGGCGG
GGCTCAGCTATTTCGTCTTCGCCTGCCTGACCTTGCGCCCCTCCACGCGGCATGCGTTGTGGCGGCACTTTGCGATGTTG
CTGCTGATGAACGCCTTGTACCTGAGCTGGGCGCGCTGGCTCGGGTTGAGCATGCAGGCGCTGGTGTGGATGCCGGTGAC
GGTGCTGGGCATGGCGGCCGTGGGCGCGGTGTACAGCATCAACGAACGCAAGGACGCGTTGCTGCGCCTGTCGCAGGACG
AAGTCCGTCGGCTGGCGGCCACCGCCGAACGCGAGCGCATCGGCCGCGACCTGCACGATCTGCTTGGCCACACCTTGTCG
CTGGTGGCGCTCAAATCCGATCTGGCCGCGCGCCTGATCGAGCGCGACCCGCAGGCCGCACGCAACGAGATCGATGCGGT
GGCGCAGGTCTCGCGCGAGGCGCTGGCACAGGTACGACGCGCGGTCACCGGCATCCGTGCTGCCGGCCTGGTTGCCGAAC
TGGCATCGGCGCGCGTGCTGCTGGACCTGGACGGCATTGCGCTGGAGCAACACCTGGAGCCACTGGCGTTGCCGCCCGAG
CACGAAACCGCGCTTGCGTTGGTCGTGCGCGAGGCGGCCACCAATGTGCAGCGCCACGCCCAGGCAAAACGCGTGCGTGT
GCAGCTGCACGCGCACGGCGAGCAGGCGGTGCTGGAGATCACCGATGACGGCCGCGGTGGCGTGATCGTGCCTGGCAACG
GCCTGGACGGCATGCGCGCACGCCTGCACAGCCTGGGTGGCGCGTTGGATGTGCAGGCCTTGCCACGCGGCATGCGATTG
CGCGCCAGTCTGCCGTTGCCGCGGCCTGCGGTCGTTGCCGCAACGCCGTCGCCGCCGGTGATGCCGCAGTCGCTTTAA

Upstream 100 bases:

>100_bases
ATGCTTTCCTTGCATATGCGAACCGCGCGTGTCTGGCTTGCGCCTGCGCAGGCGAATTGCAGCCTCGGTGGGCGATCGCA
TCGCAGCAGTCACCAGGGGC

Downstream 100 bases:

>100_bases
CGCGCCCTGCTTGCGCTGCCAAGTGCACGGCATGCGTCGGCGCTGTTATCGTGCGCAACCGTTGCATGCATACGAGCGCG
ACCGATGATCCGGGTGTTGT

Product: two-component system sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MHEAAHPYRPARSGTQTGPAVAESAHPHGSSLMRLRFPAWLRPAASSQVAARLAQGQSPWMDSVHLFWSAWVFVVPAFSA
RGYDSTWLLCTLASYPVFVLLYARMLLAPRGTLYRYAWAMAALSAALLPVYSAGLSYFVFACLTLRPSTRHALWRHFAML
LLMNALYLSWARWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQHLEPLALPPE
HETALALVVREAATNVQRHAQAKRVRVQLHAHGEQAVLEITDDGRGGVIVPGNGLDGMRARLHSLGGALDVQALPRGMRL
RASLPLPRPAVVAATPSPPVMPQSL

Sequences:

>Translated_425_residues
MHEAAHPYRPARSGTQTGPAVAESAHPHGSSLMRLRFPAWLRPAASSQVAARLAQGQSPWMDSVHLFWSAWVFVVPAFSA
RGYDSTWLLCTLASYPVFVLLYARMLLAPRGTLYRYAWAMAALSAALLPVYSAGLSYFVFACLTLRPSTRHALWRHFAML
LLMNALYLSWARWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQHLEPLALPPE
HETALALVVREAATNVQRHAQAKRVRVQLHAHGEQAVLEITDDGRGGVIVPGNGLDGMRARLHSLGGALDVQALPRGMRL
RASLPLPRPAVVAATPSPPVMPQSL
>Mature_425_residues
MHEAAHPYRPARSGTQTGPAVAESAHPHGSSLMRLRFPAWLRPAASSQVAARLAQGQSPWMDSVHLFWSAWVFVVPAFSA
RGYDSTWLLCTLASYPVFVLLYARMLLAPRGTLYRYAWAMAALSAALLPVYSAGLSYFVFACLTLRPSTRHALWRHFAML
LLMNALYLSWARWLGLSMQALVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVLLDLDGIALEQHLEPLALPPE
HETALALVVREAATNVQRHAQAKRVRVQLHAHGEQAVLEITDDGRGGVIVPGNGLDGMRARLHSLGGALDVQALPRGMRL
RASLPLPRPAVVAATPSPPVMPQSL

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=228, Percent_Identity=28.5087719298246, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46331; Mature: 46331

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEAAHPYRPARSGTQTGPAVAESAHPHGSSLMRLRFPAWLRPAASSQVAARLAQGQSPW
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCHHHCCCCHHHHHHHHHCCCCCC
MDSVHLFWSAWVFVVPAFSARGYDSTWLLCTLASYPVFVLLYARMLLAPRGTLYRYAWAM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AALSAALLPVYSAGLSYFVFACLTLRPSTRHALWRHFAMLLLMNALYLSWARWLGLSMQA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LDLDGIALEQHLEPLALPPEHETALALVVREAATNVQRHAQAKRVRVQLHAHGEQAVLEI
EEECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEE
TDDGRGGVIVPGNGLDGMRARLHSLGGALDVQALPRGMRLRASLPLPRPAVVAATPSPPV
ECCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCCCEEEEECCCCCC
MPQSL
CCCCC
>Mature Secondary Structure
MHEAAHPYRPARSGTQTGPAVAESAHPHGSSLMRLRFPAWLRPAASSQVAARLAQGQSPW
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECCHHHCCCCHHHHHHHHHCCCCCC
MDSVHLFWSAWVFVVPAFSARGYDSTWLLCTLASYPVFVLLYARMLLAPRGTLYRYAWAM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AALSAALLPVYSAGLSYFVFACLTLRPSTRHALWRHFAMLLLMNALYLSWARWLGLSMQA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVWMPVTVLGMAAVGAVYSINERKDALLRLSQDEVRRLAATAERERIGRDLHDLLGHTLS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVALKSDLAARLIERDPQAARNEIDAVAQVSREALAQVRRAVTGIRAAGLVAELASARVL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LDLDGIALEQHLEPLALPPEHETALALVVREAATNVQRHAQAKRVRVQLHAHGEQAVLEI
EEECCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEE
TDDGRGGVIVPGNGLDGMRARLHSLGGALDVQALPRGMRLRASLPLPRPAVVAATPSPPV
ECCCCCCEEECCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCCCEEEEECCCCCC
MPQSL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]