Click here to switch to the map view.

The map label for this gene is ung

Identifier: 21244549

GI number: 21244549

Start: 4499087

End: 4499812

Strand: Reverse

Name: ung

Synonym: XAC3825

Alternate gene names: 21244549

Gene position: 4499812-4499087 (Counterclockwise)

Preceding gene: 21244550

Following gene: 21244548

Centisome position: 86.94

GC content: 67.08

Gene sequence:

>726_bases
ATGACTGAAGGGGAAGGACGCATCCAGCTGGAACCGTCGTGGAAGGCAAGGGTGGGCGACTGGCTGCTGCGCCCACAGAT
GCGGGAGCTGTCGGCATTCCTGCGCCAGCGCAAGGCGGCCGGGGCGCGGGTGTTTCCGCCCGGCCCGCAGATCTTCGCCG
CCTTCGACGCGACACCGTTCGAGCAAGTCAAGGTGGTGATCCTGGGCCAGGACCCGTATCACGGCGAAGGTCAGGCGCAT
GGGCTGTGCTTCTCGGTACTGCCCGGCGTGCCGGTGCCGCCGTCGCTGCTCAATATCTACAAAGAGATCCAGGACGACCT
GGGGATCGCGCGGCCGGATCACGGCTACCTGATGCCCTGGGCGCGCCAGGGCGTGCTGCTGCTCAATGCGGTGCTGACGG
TGGAGCAGGGACGCGCCGGGGCCCACCAGAACAAGGGCTGGGAAGGCTTCACCGATCATGTGGTGGAAACCCTCAACCGC
GAGCGCGAAGGGCTGGTGTTCCTGCTGTGGGGCAGCTATGCGCAGTCCAAGGGCAAGGTCATCGACCAGACGCGCCACCG
GGTCTTGAAGGCGCCACATCCTTCGCCGCTGTCGGCGCACCGCGGCTTCCTGGGCTGCCAGCATTTTTCCAAGACCAACG
ACCATTTGCGGCGGCGTGGTCTGAGCCCGATCGACTGGTCGCTGCCACCGCGCAGCGCGCTGGACCTCACCTCCGCCGGC
GCCTGA

Upstream 100 bases:

>100_bases
CCAACGATCTGGTGCAAAAACCGATCGAAGAGCGCCTGCTTGTGACCAAGGTGTTGTTCCAGCTGCGCCTGGCACGCCTG
GAGGATCAGGCTGTCACGCT

Downstream 100 bases:

>100_bases
ACGACGCTCCCGTACATCCCGTTGCGCAACCAGTTTGTCACGGTTTGCATAGGGGCTTGGTGGTACGGTAAGCCTCGAAT
TTGGGTGCCGGGCTGTAGAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNR
EREGLVFLLWGSYAQSKGKVIDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAG
A

Sequences:

>Translated_241_residues
MTEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNR
EREGLVFLLWGSYAQSKGKVIDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAG
A
>Mature_240_residues
TEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAHG
LCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNRE
REGLVFLLWGSYAQSKGKVIDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAGA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=54.8837209302326, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=54.8837209302326, Blast_Score=231, Evalue=5e-61,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=55.7603686635945, Blast_Score=254, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=47.926267281106, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=242, Percent_Identity=44.6280991735537, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_XANAC (Q8PFZ6)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644131.1
- ProteinModelPortal:   Q8PFZ6
- SMR:   Q8PFZ6
- GeneID:   1157896
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3825
- NMPDR:   fig|190486.1.peg.3775
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   XAXO190486:XAC3825-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26769; Mature: 26638

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPF
CCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCH
EQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
HHEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGKV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
IDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAG
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHCCCCCC
A
C
>Mature Secondary Structure 
TEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPF
CCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCH
EQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
HHEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGKV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
IDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAG
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217