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The map label for this gene is norM

Identifier: 21244538

GI number: 21244538

Start: 4486290

End: 4487666

Strand: Reverse

Name: norM

Synonym: XAC3814

Alternate gene names: 21244538

Gene position: 4487666-4486290 (Counterclockwise)

Preceding gene: 21244540

Following gene: 21244537

Centisome position: 86.71

GC content: 67.61

Gene sequence:

>1377_bases
ATGTCTGTTTCTTCTGCACCCCCGTCCGCGACGCCAGGCTTCGCCTCGGAAGTGCGCACCACCGGCCTGCTTGCATTGCC
GCTGGTGCTCGGCCACGTTTCCACCGGCCTGATCGGTTTTGTCGACAACGTCATCGCCGGCCACCACGGCACCGCCACGC
TGGCTGCAGTCACCATCGGCACTTCGCTGCTGTGGCTGCCGATGCTGGTGCCGATCGGCACCTTGATTTCGTTGACCGCC
TCGGTCTCGCAATTGCTCGGCGCCGGCCGCGAGCGCGAGATCGGGCCGCTGTTCCGACAGGCGCTGTGGCTGTCGCTGGG
GCTGAGTGCGCTGATGTTCGTGTTCCTGAGCGTGGTGCCGCCGTTGCTGCCCACCTTCGGGATTGCGCCGGACATCGTGC
CCGGTGCCACCGCGTTCCTGCACGCAGTCCGCTGGGGCGTGCCGGCGCTGACGTTCTACTTCTGCATGCGCTACCTCAGC
GAGGGCATGCACTGGACGCTGCCGACCATGCTGCTGGGCTTTGGCGGCTTGCTGGTCCTGGCACCGGTGGGCTATGCGCT
GACTTATGGCAAGTTCGGCTTCGCCGAGCACGGTGCCGAAGGGCTGGGCATGGCCTCGGCCATCACCATGTGGGTGCAGG
CGAGCGTGTTCGCGCTGTATTTGTGGCGCGCGCGACGTTTTGCGCATCTGCAATTGTTCGCCCACCTGGAAGGGCCGCGC
TGGCGCGCCATCGGCGAGTTGCTACGCACCGGCTTGCCGATCGGCATTACGGTTTTGATGGAAGGCGGGTTGTTCATCGT
CACCGCGCTGTTGATCGGCCGGCTGGGCTCCACCGAAGCGGCCGCGCACCAGATTGCGATCAACGTCGCGCAGCTGTGTT
TCATGATCCCGATGGGCGTGGCCGAGGCCACCACCGTGCGCGTGGGCCACGCAGTGGGCCGCGGCGACCCGCAGGCGATG
CGGCGCGCAGCCTGGGCCGGCTATGCCATCGTGCTGGGCACGCAAGCGCTATCGGCCAGCGCGCTGCTGCTGGGCCACGA
TGCCATCGTCGGCGTCTATACCGACGACGTGGCCGTGGCCGCGCTGGCCTCGGTGTTGCTGCTGTTTGCCGCCACGTTCC
AGTTTCCCGACGGCATCCAGGTGCTGTCGGCCGGCGCGCTGCGCGGGCTCAAGGACACCCGCGTGCCGATGTTCTTGGCG
ATGTTTTCGTACTGGGGCGTGGGCATGCCGATCGGCGCCGGGCTCGGCCTGGGGCTGGGCTGGGGACCAAAGGGCATGTG
GGTGGGCCTGATCCTGGGCCTGACGGTGGCGTCGATCCTGATGGGGCTGCGCTTTCGCCAGACCAGCCGGCGACTGACCG
CCACCGTGACACCCTGA

Upstream 100 bases:

>100_bases
GCAAGGCCGCAGTCGGAAAGTAGGCGTAAGATAGCCGGCCCGCGCGACCCGGTGCCAGCGCCTCCCGGCACGGCCGTAGT
CCGCGCAGCGATCGGTTGTC

Downstream 100 bases:

>100_bases
CTTCCAGCGCATCCCGCGCGCGCTGCGCAGCCGGTATGCTGGGCGCCATCGATCTGTATGCAGCGTCTTTCGACGGAGCT
TTCCATGAACCACCCCGTGC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTA
SVSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATAFLHAVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGMASAITMWVQASVFALYLWRARRFAHLQLFAHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPQAM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP

Sequences:

>Translated_458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTA
SVSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATAFLHAVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGMASAITMWVQASVFALYLWRARRFAHLQLFAHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPQAM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP
>Mature_457_residues
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTAS
VSQLLGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATAFLHAVRWGVPALTFYFCMRYLSE
GMHWTLPTMLLGFGGLLVLAPVGYALTYGKFGFAEHGAEGLGMASAITMWVQASVFALYLWRARRFAHLQLFAHLEGPRW
RAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPQAMR
RAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTRVPMFLAM
FSYWGVGMPIGAGLGLGLGWGPKGMWVGLILGLTVASILMGLRFRQTSRRLTATVTP

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI153792564, Length=421, Percent_Identity=24.9406175771971, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI22907060, Length=434, Percent_Identity=27.6497695852535, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI38261960, Length=454, Percent_Identity=23.568281938326, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=37.1937639198218, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI226510954, Length=269, Percent_Identity=27.1375464684015, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=444, Percent_Identity=23.1981981981982, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_XANAC (Q8PG07)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644120.1
- GeneID:   1157885
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3814
- NMPDR:   fig|190486.1.peg.3764
- HOGENOM:   HBG479615
- OMA:   LYFCMRY
- ProtClustDB:   PRK01766
- BioCyc:   XAXO190486:XAC3814-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 48164; Mature: 48033

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12560254)-; HASH(0x12b46260)-; HASH(0xdc99d4c)-; HASH(0x12eac4a4)-; HASH(0x12bced1c)-; HASH(0x12c77d7c)-; HASH(0x132a5350)-; HASH(0x12db3ab8)-; HASH(0x11b0304c)-; HASH(0x12fae1a0)-; HASH(0x11e58b3c)-; HASH(0x132a565c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
>Mature Secondary Structure 
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH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CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217