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The map label for this gene is sppA [H]

Identifier: 21244537

GI number: 21244537

Start: 4484304

End: 4486205

Strand: Reverse

Name: sppA [H]

Synonym: XAC3813

Alternate gene names: 21244537

Gene position: 4486205-4484304 (Counterclockwise)

Preceding gene: 21244538

Following gene: 21244535

Centisome position: 86.68

GC content: 66.09

Gene sequence:

>1902_bases
ATGAACCACCCCGTGCGTCGCAATCCCATCGCCAGCTTCTTCGTCGGCCTGTGGGATGTGATGAATTTCACCCGGCGCCT
GATTTTCAACCTGGTGTTCTTCGGTTTCCTGTTTTTGCTGCTGCTGGTGTTCGTGGTGGCGCTCGCGCGTGGTGATGGCA
CCAAGCCGCTGGCCGAGCGCACTACCCTGGTGATCAACCCGGAAGGCACGCTGGTCGAACAATTCAGTGCCGACCCGGTC
AGCCGGTCGCTGGCCAAGGCGGTCGGCGACAAGAGTGCCGAAGAAGTGCAACTGCGCGACCTGGTGCGCGTGATCGAAGC
GGCCGGCAAGGACCGCAAGATCGAGCGCGTGCTGTTGAACCTGGACAAGCTGCAACCGTCCGGATTCGCTTCCCAACGCG
AAGTGGCCGTCGCGTTGCAGAAGTTGCGCGCCTCCGGCAAGCAGATCGTGGCCTTCAGCGAGAGCATGAGCCAGGGCCAG
TACCTGCTCGCCGCACAGGCCAACGAGGTGTATCTGGACCCGATGGGCAGCGTGCTGCTGGAAGGCCTTGGCCGCTATCG
CCAGTACTTCCGCGAAGGCCTGCAGGACAAGCTCGGCGTGGACGTGCATCTGTTCCGCGTTGGCGAGTACAAGTCTGCAG
CCGAGCCGTACATCCTGGACGCGGCCTCGGCCGATGCCAAGGAAGCGGATCTGTTCTGGATGAACGATGTGTGGCGGCGC
TACCTGGCCGACGTGGGCACCGCACGCAAGCTGAGCCCGGCGCAGCTGGCTGCCGGTATCGACACGCTGCCCGAAGGCGT
GGCCGCCGCCGGTGGCGACCTGGCCAAGTTCGCGCTGCAACAGAAGCTGGTGGACGGGCTCAAGACGCGCGAGGAAGTCG
ATGCGCTGCTGGTCCAGCGCGGCGTCGCCGACAGCGATGCCGACAGCGGTTTCCGCAATATCGGGTTCAACGATTATCTG
AGCCAGCTGCAGGCGCAGCGTTCGCCCATGGACAGTCGCCCGCAGGTGGCGGTGGTCGTGGCGGCGGGCGAGATCAGCGG
TGGCGAACAGCCGGCCGGGCGCATCGGTGGCGAGTCCACGGCGGCGCTGCTGCGCCAGGCGCGCGACGACGATGACGTGA
AGGCGGTGGTGCTGCGCGTGGATTCGCCCGGTGGCGAAGTCTTCGCCTCCGAGCAGATCCGCCGCGAAGTGGTTGCGCTC
AAGCAGGCCGGCAAGCCGGTGGTGGTGTCGATGGGCGATCTTGCCGCTTCCGGCGGTTACTGGATCAGCATGAATGCCGA
TCGCATCTACGCCGACCCGTCGACCATCAGCGGCTCCATCGGCATCTTCGGCATGGTGCCGAATCTGACCCGTGCGCTGG
ACAAGATCGGCGTGCACACCGACGGCGTGGCCACCACGCGGTTCGCCGGTGCGTTCGACATCACCCGTCCGCTGGATCCG
GCTGCCGGCCAGGTCATCCAGGCGGTGATCAACAAGGGCTACGCCGACTTCACCGGCAAGGTGGCGCAGGCGCGTCACCA
GTCGGTGGACGCGATCGACAAGGTTGCGCGTGGCCGTGTGTGGAGCGGTGCGCAGGCCAAGGAGCGTGGATTGGTGGATG
CGTTCGGCGGCATGCAGGAAGCGGTGGCCGATGCGGCCGACCGCGCCAAGCTGAGCCGCGGCAAGTTCCGCGTGCGCTAT
GTGGAAAAGCCGGCCACGCCGTTCTCGCAGTTCATGAGCGGGTTTGCCGGCAGCCGCATGGGTGCCTGGATGCTGAGCGA
CTCGGGCATGGCGCGCGCGCTGCTGGCCCGCTCGTTGCCGGAAGTGGACAGCCAACTGCGCTTTGTCGAAAGCGCCGTGC
ACGACAGCAAGGCAGGCGGCACGCCGGTCAAGTCGCTGGCCTATTGCTTCTGCGGGTTCTGA

Upstream 100 bases:

>100_bases
CACCGTGACACCCTGACTTCCAGCGCATCCCGCGCGCGCTGCGCAGCCGGTATGCTGGGCGCCATCGATCTGTATGCAGC
GTCTTTCGACGGAGCTTTCC

Downstream 100 bases:

>100_bases
CGCGTTGCGCTCAGTGAGCGAGTGATGCATCGACAACGCCGGCCATGTGCCGGCGTTGTTGTTTCTAAAGTCGGGAGATG
CGGCGTTTTGAACGCACAAA

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNHPVRRNPIASFFVGLWDVMNFTRRLIFNLVFFGFLFLLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAEEVQLRDLVRVIEAAGKDRKIERVLLNLDKLQPSGFASQREVAVALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWRR
YLADVGTARKLSPAQLAAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVQRGVADSDADSGFRNIGFNDYL
SQLQAQRSPMDSRPQVAVVVAAGEISGGEQPAGRIGGESTAALLRQARDDDDVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVATTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMQEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMSGFAGSRMGAWMLSDSGMARALLARSLPEVDSQLRFVESAVHDSKAGGTPVKSLAYCFCGF

Sequences:

>Translated_633_residues
MNHPVRRNPIASFFVGLWDVMNFTRRLIFNLVFFGFLFLLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAEEVQLRDLVRVIEAAGKDRKIERVLLNLDKLQPSGFASQREVAVALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWRR
YLADVGTARKLSPAQLAAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVQRGVADSDADSGFRNIGFNDYL
SQLQAQRSPMDSRPQVAVVVAAGEISGGEQPAGRIGGESTAALLRQARDDDDVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVATTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMQEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMSGFAGSRMGAWMLSDSGMARALLARSLPEVDSQLRFVESAVHDSKAGGTPVKSLAYCFCGF
>Mature_633_residues
MNHPVRRNPIASFFVGLWDVMNFTRRLIFNLVFFGFLFLLLLVFVVALARGDGTKPLAERTTLVINPEGTLVEQFSADPV
SRSLAKAVGDKSAEEVQLRDLVRVIEAAGKDRKIERVLLNLDKLQPSGFASQREVAVALQKLRASGKQIVAFSESMSQGQ
YLLAAQANEVYLDPMGSVLLEGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWRR
YLADVGTARKLSPAQLAAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVQRGVADSDADSGFRNIGFNDYL
SQLQAQRSPMDSRPQVAVVVAAGEISGGEQPAGRIGGESTAALLRQARDDDDVKAVVLRVDSPGGEVFASEQIRREVVAL
KQAGKPVVVSMGDLAASGGYWISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVATTRFAGAFDITRPLDP
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMQEAVADAADRAKLSRGKFRVRY
VEKPATPFSQFMSGFAGSRMGAWMLSDSGMARALLARSLPEVDSQLRFVESAVHDSKAGGTPVKSLAYCFCGF

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=626, Percent_Identity=41.5335463258786, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1787527, Length=256, Percent_Identity=30.078125, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 68247; Mature: 68247

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPVRRNPIASFFVGLWDVMNFTRRLIFNLVFFGFLFLLLLVFVVALARGDGTKPLAER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
TTLVINPEGTLVEQFSADPVSRSLAKAVGDKSAEEVQLRDLVRVIEAAGKDRKIERVLLN
EEEEECCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LDKLQPSGFASQREVAVALQKLRASGKQIVAFSESMSQGQYLLAAQANEVYLDPMGSVLL
HHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEECCCEEEECHHHHHHH
EGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWRR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLADVGTARKLSPAQLAAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVQR
HHHHCCCCCCCCHHHHHHCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVADSDADSGFRNIGFNDYLSQLQAQRSPMDSRPQVAVVVAAGEISGGEQPAGRIGGEST
CCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
AALLRQARDDDDVKAVVLRVDSPGGEVFASEQIRREVVALKQAGKPVVVSMGDLAASGGY
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
WISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVATTRFAGAFDITRPLDP
EEEECCCEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCH
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMQE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCHHH
AVADAADRAKLSRGKFRVRYVEKPATPFSQFMSGFAGSRMGAWMLSDSGMARALLARSLP
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCH
EVDSQLRFVESAVHDSKAGGTPVKSLAYCFCGF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNHPVRRNPIASFFVGLWDVMNFTRRLIFNLVFFGFLFLLLLVFVVALARGDGTKPLAER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHC
TTLVINPEGTLVEQFSADPVSRSLAKAVGDKSAEEVQLRDLVRVIEAAGKDRKIERVLLN
EEEEECCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LDKLQPSGFASQREVAVALQKLRASGKQIVAFSESMSQGQYLLAAQANEVYLDPMGSVLL
HHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEECCCEEEECHHHHHHH
EGLGRYRQYFREGLQDKLGVDVHLFRVGEYKSAAEPYILDAASADAKEADLFWMNDVWRR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
YLADVGTARKLSPAQLAAGIDTLPEGVAAAGGDLAKFALQQKLVDGLKTREEVDALLVQR
HHHHCCCCCCCCHHHHHHCHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVADSDADSGFRNIGFNDYLSQLQAQRSPMDSRPQVAVVVAAGEISGGEQPAGRIGGEST
CCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
AALLRQARDDDDVKAVVLRVDSPGGEVFASEQIRREVVALKQAGKPVVVSMGDLAASGGY
HHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
WISMNADRIYADPSTISGSIGIFGMVPNLTRALDKIGVHTDGVATTRFAGAFDITRPLDP
EEEECCCEEEECCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCH
AAGQVIQAVINKGYADFTGKVAQARHQSVDAIDKVARGRVWSGAQAKERGLVDAFGGMQE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHCCHHH
AVADAADRAKLSRGKFRVRYVEKPATPFSQFMSGFAGSRMGAWMLSDSGMARALLARSLP
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCH
EVDSQLRFVESAVHDSKAGGTPVKSLAYCFCGF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3522590; 9097039; 9278503; 7973728 [H]