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The map label for this gene is dtd

Identifier: 21244513

GI number: 21244513

Start: 4458158

End: 4458598

Strand: Reverse

Name: dtd

Synonym: XAC3789

Alternate gene names: 21244513

Gene position: 4458598-4458158 (Counterclockwise)

Preceding gene: 21244515

Following gene: 21244512

Centisome position: 86.15

GC content: 66.21

Gene sequence:

>441_bases
ATGCTTGCACTGATCCAGCGCGTCACCCGCGCCAGCGTCACGGTCGATGACCAGATCGTCGGGCAGATCGGTCCCGGGCT
GCTGGCGCTGATCGGCGTGGAGCCAGGCGACAGCGATGCGCAGATCCGGCGCCTGGCCGAGCGGCTGCTGAGCTACCGGG
TGTTCGGCGACGACGCTGGCAAGATGAACCGCTCACTCGCCGACACTGGCGGCGGCCTGCTGCTAGTCAGCCAGTTCACC
CTGGCTGCGGACACCAGTTCCGGTAACCGCCCAGGCTTCAGCACCGCCGCGCCGCCACTGGAGGCTGAACCGGCGTTCAA
TCGATTGGCGGCGATCTGTCGCGAAAAACATCGCGGCGGGGTGGAAACCGGGCGTTTCGGTGCCCATATGGTTGTCGACC
TGGTCAACGATGGCCCGGTGACCTTCCTTCTCAGACCCTAG

Upstream 100 bases:

>100_bases
CCGCGCAATTCTAAACAGCGCAGACCGCGAAGGCCCGCGCGTGACAGTGCCGGCGGCGCTGGGCATGCTGCGCGGCACAG
TTTGCTGCCCGAGAATGCCC

Downstream 100 bases:

>100_bases
ATACAACACGTCCACCAGCGGTCCCGTCTTGAATCCGGCAGACCGGGCTTCACGCTGGTATAATGCTAGGTTCTCTTTCC
AATCTCAAAGCCGGTGGCGC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MLALIQRVTRASVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLADTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNRLAAICREKHRGGVETGRFGAHMVVDLVNDGPVTFLLRP

Sequences:

>Translated_146_residues
MLALIQRVTRASVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLADTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNRLAAICREKHRGGVETGRFGAHMVVDLVNDGPVTFLLRP
>Mature_146_residues
MLALIQRVTRASVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLADTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNRLAAICREKHRGGVETGRFGAHMVVDLVNDGPVTFLLRP

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=146, Percent_Identity=39.7260273972603, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=54.4827586206897, Blast_Score=158, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=38.4615384615385, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319982, Length=146, Percent_Identity=34.9315068493151, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281361569, Length=145, Percent_Identity=38.6206896551724, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_XANAC (Q8PG32)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644095.1
- ProteinModelPortal:   Q8PG32
- SMR:   Q8PG32
- GeneID:   1157860
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3789
- NMPDR:   fig|190486.1.peg.3739
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   XAXO190486:XAC3789-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15440; Mature: 15440

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALIQRVTRASVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAG
CHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCH
KMNRSLADTGGGLLLVSQFTLAADTSSGNRPGFSTAAPPLEAEPAFNRLAAICREKHRGG
HHHCHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VETGRFGAHMVVDLVNDGPVTFLLRP
CCCCCCCCEEEEEEECCCCEEEEECC
>Mature Secondary Structure
MLALIQRVTRASVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAG
CHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCH
KMNRSLADTGGGLLLVSQFTLAADTSSGNRPGFSTAAPPLEAEPAFNRLAAICREKHRGG
HHHCHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VETGRFGAHMVVDLVNDGPVTFLLRP
CCCCCCCCEEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217