Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 21244507

GI number: 21244507

Start: 4452924

End: 4453694

Strand: Reverse

Name: map [H]

Synonym: XAC3782

Alternate gene names: 21244507

Gene position: 4453694-4452924 (Counterclockwise)

Preceding gene: 21244508

Following gene: 21244506

Centisome position: 86.05

GC content: 61.74

Gene sequence:

>771_bases
GTGATCAAGTCGCCCGACGAGATCGCGCTGATGGCGGTGTCTGGTCAGCTCCTAGCGCAGGTATTCAATGCGCTGGATCG
CTTGCCGCTGGAAGGTCGCAGCACGCTGGAACTCAACGAGTTTGTCGAGCGCATGATTGTCGATGAGCTCGACGCACGGC
CTGCGAGCAAGGGGCAGTACGGTTTCGAGTTCGTACTCAACGCATCCATCGACGATGTGGTGTGCCATGGCGTGCCATCG
GCCGATGACGTGTTGCGGAGCGGGCAGATCGTCAACGTGGACATTACGCTGGAAAAGAATGGCTATATCGCCGATTCCAG
TACTACGTACCTGGTGGGCGAGGTCGCTTACCCAGCGCGTCGGCTGGTGCAGGCCACGTATCAGGCGATGTGGAAAGGGA
TTGCCGCGGTGCGCCCGGGCGCACGCTTGGGCGATATCGGTCATGCCATTGCGCGGCACGCGCATGCGCACGGCTACAGC
GTGGTCAAGGAATACTGTGGGCACGGCATCGGCCGTGAGATGCATGAAGACCCGCAGATTCTGCACTACGGCCACGCGGG
CACCGGGTTGGCATTGCAGGAAGGCATGGTGTTCACCATCGAGCCGATGATTAACCAGGGCCGTGCGGCGATCCGCTCGC
AACCGGATCAGTGGCCGGTGCATACGCGCGATGGCAAATTGTCGGCGCAGTTCGAGCATACCGTGGCGGTGACGCGTACT
GGCGTGCGTGTGTTGACCTTGCGGCCCGGCGAAGTGCCTCCAGTGCGGTAA

Upstream 100 bases:

>100_bases
TGCTGTGCGAAATGCATCCTGATACGACGTTTCAGCAGATCGTGGCCGAACAGTTGCGCGCGGCGGGCGTGCGGCCGCAA
GCCTTGAAACCGGGCCGGGT

Downstream 100 bases:

>100_bases
TGGTGGCGGTGTTGGTGGCCAATACCGTCGTGCGGCAGGTGTTGGGTTATTCGTTCTCCACCTGGCGGCTGCATCTGCGC
GGCGAACACATCCGCAGTGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIKSPDEIALMAVSGQLLAQVFNALDRLPLEGRSTLELNEFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPS
ADDVLRSGQIVNVDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHAHAHGYS
VVKEYCGHGIGREMHEDPQILHYGHAGTGLALQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGKLSAQFEHTVAVTRT
GVRVLTLRPGEVPPVR

Sequences:

>Translated_256_residues
MIKSPDEIALMAVSGQLLAQVFNALDRLPLEGRSTLELNEFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPS
ADDVLRSGQIVNVDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHAHAHGYS
VVKEYCGHGIGREMHEDPQILHYGHAGTGLALQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGKLSAQFEHTVAVTRT
GVRVLTLRPGEVPPVR
>Mature_256_residues
MIKSPDEIALMAVSGQLLAQVFNALDRLPLEGRSTLELNEFVERMIVDELDARPASKGQYGFEFVLNASIDDVVCHGVPS
ADDVLRSGQIVNVDITLEKNGYIADSSTTYLVGEVAYPARRLVQATYQAMWKGIAAVRPGARLGDIGHAIARHAHAHGYS
VVKEYCGHGIGREMHEDPQILHYGHAGTGLALQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGKLSAQFEHTVAVTRT
GVRVLTLRPGEVPPVR

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=41.2244897959184, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=36, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=43.0830039525692, Blast_Score=225, Evalue=2e-60,
Organism=Escherichia coli, GI1788728, Length=211, Percent_Identity=27.9620853080569, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=244, Percent_Identity=38.9344262295082, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=223, Percent_Identity=41.7040358744395, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355531, Length=243, Percent_Identity=37.037037037037, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=37.5510204081633, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27982; Mature: 27982

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSPDEIALMAVSGQLLAQVFNALDRLPLEGRSTLELNEFVERMIVDELDARPASKGQY
CCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GFEFVLNASIDDVVCHGVPSADDVLRSGQIVNVDITLEKNGYIADSSTTYLVGEVAYPAR
CEEEEEECCHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCEEECCCCEEEEEEHHHHHH
RLVQATYQAMWKGIAAVRPGARLGDIGHAIARHAHAHGYSVVKEYCGHGIGREMHEDPQI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LHYGHAGTGLALQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGKLSAQFEHTVAVTRT
EEECCCCCCCEECCCEEEEEECHHCCCHHHHHCCCCCCCCCCCCCCEEEEEHHEEEEEEC
GVRVLTLRPGEVPPVR
CEEEEEECCCCCCCCC
>Mature Secondary Structure
MIKSPDEIALMAVSGQLLAQVFNALDRLPLEGRSTLELNEFVERMIVDELDARPASKGQY
CCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GFEFVLNASIDDVVCHGVPSADDVLRSGQIVNVDITLEKNGYIADSSTTYLVGEVAYPAR
CEEEEEECCHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCEEECCCCEEEEEEHHHHHH
RLVQATYQAMWKGIAAVRPGARLGDIGHAIARHAHAHGYSVVKEYCGHGIGREMHEDPQI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LHYGHAGTGLALQEGMVFTIEPMINQGRAAIRSQPDQWPVHTRDGKLSAQFEHTVAVTRT
EEECCCCCCCEECCCEEEEEECHHCCCHHHHHCCCCCCCCCCCCCCEEEEEHHEEEEEEC
GVRVLTLRPGEVPPVR
CEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]