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The map label for this gene is ybdR [H]

Identifier: 21244472

GI number: 21244472

Start: 4422761

End: 4423924

Strand: Direct

Name: ybdR [H]

Synonym: XAC3747

Alternate gene names: 21244472

Gene position: 4422761-4423924 (Clockwise)

Preceding gene: 21244469

Following gene: 21244474

Centisome position: 85.45

GC content: 62.54

Gene sequence:

>1164_bases
ATGCTTGCCCTCAACTACCACGGCTCACGCGATGTACGAGTGGAAACCGTGCCCGGTCCACTCTTGGTCGAACGCGACGA
CCTGATCCTGCGCGTCACCGCCACGGCCATCTGTGGCTCTGACCTGCATCTGTATCGCGGCAAGATTCCCGACCTGCGCC
CCGGCGACATTCTCGGCCACGAATTCATGGGCATCGTGGAAGAGGTCGGCCCGGACGTCACGGCGGTCAAGCCGGGCGAC
CGGGTCGTGATTCCGTTCGTGGTCGCGTGTGGACGCTGTTTCCACTGCGTGCTGCAGGAATTTTCCGCGTGCGAAACCAC
CAATACCGGCAAGGGCGCGGCGCTCAATCACAAGGACATGCGCCCGCCCGCCGCGCTGTTCGGCTTCAGCCATTTGTACG
GCGGATTGTCCGGCGGCCAGGCCGAATACGTGCGCGTGCCCAAGGCCAATGTCGGCCCACTGGCGGTGCCCGATGCCTTG
CACGATGAGCAGGTCTTGTTCTTGTCCGACATTCTGCCGACCGGGTATCAAGCCGTCGTCAACGCAGGCGTCAAACAGGG
CTCGACCGTTGCCATCTTCGGTGCCGGCCCGGTTGGTCTGATGGCCGCGGCGTGCTGCCGCATGTTGGGCGCAGAGCGCG
TCTTCATGGTCGACCGGCACGCGTACCGGCTCGATTTTGCGTCCAGGACCTATGGTGTGATCCCGATCAATTTCGACGAG
GTCGACGATCCGGCCGACGTGATCGTCTCGCAAACCAATGGCCGGGGCGTCGATGCCAGCATCGAGGCAGTCGGCTTCGA
GGCCGAAGGCAGCGCCATCGAAACCGCACTGACCAACCTGAAGCTGGAAGGCAGCAGCGGCGTGGCGATCCGCCAGTGCA
TCGCCGCAACCCGTCGCTGCGGTGTGGTGAGCGTGCCCGGCGTATATGCAGGCTTCATCCACGCCTTCATGTTTGGCGAT
GCGTTCGACAAGGGCTTGACCTTCAAGATGGGCCAGACGCATGTGCAAAAGCACATGCCGCACTTGCTGGAATGCATCGG
CAATGGTCAGCTCAAGCCAAGCGCGATCATCTCGCACCGCATGTCGTTGGCTGATGCAGCGCGTGGCTATGACCTGTTCG
ACAAGAAACAGGACGATTGCCGCAAGGTTGTGCTCACGCCTTGA

Upstream 100 bases:

>100_bases
CGCGTCCACACCGCGCCTACGTCATGTGCTGACGGGCTTAACACCGCTGCACCAACACTGATAGTGCGCTGCCGCGTCCC
GATGCCCACAGGAGACAAAG

Downstream 100 bases:

>100_bases
ATGCATGAGTGACGCATACGCAGACGGCGCGATCTCGGCCGCGCCGTCTGCGTTTTGTACAGCCGTTGAGCGCTGGGAAG
CAGACTCAGTCCAGTGGCTT

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MLALNYHGSRDVRVETVPGPLLVERDDLILRVTATAICGSDLHLYRGKIPDLRPGDILGHEFMGIVEEVGPDVTAVKPGD
RVVIPFVVACGRCFHCVLQEFSACETTNTGKGAALNHKDMRPPAALFGFSHLYGGLSGGQAEYVRVPKANVGPLAVPDAL
HDEQVLFLSDILPTGYQAVVNAGVKQGSTVAIFGAGPVGLMAAACCRMLGAERVFMVDRHAYRLDFASRTYGVIPINFDE
VDDPADVIVSQTNGRGVDASIEAVGFEAEGSAIETALTNLKLEGSSGVAIRQCIAATRRCGVVSVPGVYAGFIHAFMFGD
AFDKGLTFKMGQTHVQKHMPHLLECIGNGQLKPSAIISHRMSLADAARGYDLFDKKQDDCRKVVLTP

Sequences:

>Translated_387_residues
MLALNYHGSRDVRVETVPGPLLVERDDLILRVTATAICGSDLHLYRGKIPDLRPGDILGHEFMGIVEEVGPDVTAVKPGD
RVVIPFVVACGRCFHCVLQEFSACETTNTGKGAALNHKDMRPPAALFGFSHLYGGLSGGQAEYVRVPKANVGPLAVPDAL
HDEQVLFLSDILPTGYQAVVNAGVKQGSTVAIFGAGPVGLMAAACCRMLGAERVFMVDRHAYRLDFASRTYGVIPINFDE
VDDPADVIVSQTNGRGVDASIEAVGFEAEGSAIETALTNLKLEGSSGVAIRQCIAATRRCGVVSVPGVYAGFIHAFMFGD
AFDKGLTFKMGQTHVQKHMPHLLECIGNGQLKPSAIISHRMSLADAARGYDLFDKKQDDCRKVVLTP
>Mature_387_residues
MLALNYHGSRDVRVETVPGPLLVERDDLILRVTATAICGSDLHLYRGKIPDLRPGDILGHEFMGIVEEVGPDVTAVKPGD
RVVIPFVVACGRCFHCVLQEFSACETTNTGKGAALNHKDMRPPAALFGFSHLYGGLSGGQAEYVRVPKANVGPLAVPDAL
HDEQVLFLSDILPTGYQAVVNAGVKQGSTVAIFGAGPVGLMAAACCRMLGAERVFMVDRHAYRLDFASRTYGVIPINFDE
VDDPADVIVSQTNGRGVDASIEAVGFEAEGSAIETALTNLKLEGSSGVAIRQCIAATRRCGVVSVPGVYAGFIHAFMFGD
AFDKGLTFKMGQTHVQKHMPHLLECIGNGQLKPSAIISHRMSLADAARGYDLFDKKQDDCRKVVLTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=27.5, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501939, Length=348, Percent_Identity=27.5862068965517, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI71565152, Length=355, Percent_Identity=25.6338028169014, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI34577061, Length=348, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501929, Length=349, Percent_Identity=27.7936962750716, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501933, Length=237, Percent_Identity=32.9113924050633, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565154, Length=241, Percent_Identity=32.7800829875519, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI71743840, Length=352, Percent_Identity=26.7045454545455, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.628895184136, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=66.2371134020619, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1787863, Length=373, Percent_Identity=24.9329758713137, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786552, Length=356, Percent_Identity=27.8089887640449, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790045, Length=382, Percent_Identity=26.9633507853403, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788073, Length=392, Percent_Identity=25.2551020408163, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082125, Length=266, Percent_Identity=28.1954887218045, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=28.3842794759825, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=349, Percent_Identity=25.214899713467, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788407, Length=287, Percent_Identity=25.4355400696864, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790718, Length=193, Percent_Identity=29.0155440414508, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788075, Length=381, Percent_Identity=24.9343832020997, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=388, Percent_Identity=26.2886597938144, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=27.2222222222222, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=383, Percent_Identity=25.8485639686684, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=358, Percent_Identity=27.3743016759777, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=289, Percent_Identity=27.3356401384083, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=307, Percent_Identity=29.3159609120521, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=394, Percent_Identity=25.6345177664975, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=267, Percent_Identity=31.0861423220974, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17737897, Length=267, Percent_Identity=31.4606741573034, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17737895, Length=241, Percent_Identity=29.045643153527, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 41393; Mature: 41393

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALNYHGSRDVRVETVPGPLLVERDDLILRVTATAICGSDLHLYRGKIPDLRPGDILGH
CEEEECCCCCCEEEEECCCCEEEECCCEEEEEEEEHHCCCCCCEECCCCCCCCCCCHHHH
EFMGIVEEVGPDVTAVKPGDRVVIPFVVACGRCFHCVLQEFSACETTNTGKGAALNHKDM
HHHHHHHHHCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RPPAALFGFSHLYGGLSGGQAEYVRVPKANVGPLAVPDALHDEQVLFLSDILPTGYQAVV
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHH
NAGVKQGSTVAIFGAGPVGLMAAACCRMLGAERVFMVDRHAYRLDFASRTYGVIPINFDE
HHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCEEEEEECCCC
VDDPADVIVSQTNGRGVDASIEAVGFEAEGSAIETALTNLKLEGSSGVAIRQCIAATRRC
CCCCHHEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHCC
GVVSVPGVYAGFIHAFMFGDAFDKGLTFKMGQTHVQKHMPHLLECIGNGQLKPSAIISHR
CEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MSLADAARGYDLFDKKQDDCRKVVLTP
HHHHHHHCCCCCCCCCCCHHCEEECCC
>Mature Secondary Structure
MLALNYHGSRDVRVETVPGPLLVERDDLILRVTATAICGSDLHLYRGKIPDLRPGDILGH
CEEEECCCCCCEEEEECCCCEEEECCCEEEEEEEEHHCCCCCCEECCCCCCCCCCCHHHH
EFMGIVEEVGPDVTAVKPGDRVVIPFVVACGRCFHCVLQEFSACETTNTGKGAALNHKDM
HHHHHHHHHCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RPPAALFGFSHLYGGLSGGQAEYVRVPKANVGPLAVPDALHDEQVLFLSDILPTGYQAVV
CCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCHHHHH
NAGVKQGSTVAIFGAGPVGLMAAACCRMLGAERVFMVDRHAYRLDFASRTYGVIPINFDE
HHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCEEEEEECCCC
VDDPADVIVSQTNGRGVDASIEAVGFEAEGSAIETALTNLKLEGSSGVAIRQCIAATRRC
CCCCHHEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHCC
GVVSVPGVYAGFIHAFMFGDAFDKGLTFKMGQTHVQKHMPHLLECIGNGQLKPSAIISHR
CEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MSLADAARGYDLFDKKQDDCRKVVLTP
HHHHHHHCCCCCCCCCCCHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]