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The map label for this gene is alr

Identifier: 21244412

GI number: 21244412

Start: 4364048

End: 4365148

Strand: Reverse

Name: alr

Synonym: XAC3687

Alternate gene names: 21244412

Gene position: 4365148-4364048 (Counterclockwise)

Preceding gene: 21244413

Following gene: 21244410

Centisome position: 84.34

GC content: 69.21

Gene sequence:

>1101_bases
GTGCGTCCTGCGCAAGCGTCGATCGATCTGGAGGCATTGCGCCACAACTACCGCCTGGCCAAGCGCCTGGGCGGCAGCAA
GGCGCTGGCGGTGGTCAAGGCCGACGCGTACGGACACGGTGCAGTGCGCTGCGCGCAGGCGCTGGAGCCGGAAGCCGATG
GCTTTGCAGTGGCCTGCATCGAAGAGGCGCTGGAACTGCGCCAGGCCGGCATCCGTGCGCCGATCCTGTTGCTGGAAGGA
TTCTTCGAACACGACGAGCTGCGCCTGATCGCCGAGCACGACCTGTGGACGGTGGCTGCCACGCCGCAGCAGGTGCGCGC
GCTGGCCGAGTTCCAGAGCCCGCGGCCGTTGCGGGTATGGTTGAAGCTGGACAGCGGCATGCATCGGCTGGGTCTGTCGC
CGGAAGATTTCCGCGCCGCCTGGTTGCGCCTGCGGGGGCTGCCGCAGATCGCCTCGCTGGTGCTGATGACCCATCTGGCG
CGTGCCGACGAATTGGACTGCAGCCGCACCGACGAGCAGGCGGTGGCCTTTGCGCTCACCGCAGGCGGCATGCGCGCGGA
AACCAGCCTGCGCAATTCGCCCGGCCTGCTCGGCTGGCCGGCGCTGCGCAACGACTGGTCGCGCCCGGGGCTGATGTTGT
ACGGCGCCAACCCGTTCCCGCAGGACACCGAAAACACCGCGCAGCTGCGCCCGGTGATGACGCTGCGCTCGCGCATCATT
TCGGTTCGCGAGCTGCCGGCCGGCGAACCGGTGGGCTACGGCGCACGCTTTGTTGCCGAGCGGCCGACGCGTGTCGGCGT
CGTGGCGATGGGCTATGCCGACGGCTACCCGCAGTTCGCACCCAACGGCACCCCGGTGCTGGTGGACGGCCAGGTCTGTC
CGTTGGCCGGTCGCGTCTCGATGGACATGCTCACCGTGGACCTCACCGACCACCCGCAGGCCGACATCGGCACGCCGGTG
CAGCTGTGGGGTGATGCACCGCAGGTCGGCGCACTGGCCGCGCAATGCAACGTCAGCGCGTACCAACTGCTGTGCGGGCT
CAAGCGGGTGCCGCGGGTGTATATGGGCGAGGCAGCAGCGAAGGAGGGAGTCACGCGTTGA

Upstream 100 bases:

>100_bases
ACCTCATGCAGGGCCGCACGCCCGAGATCGATACCGAAGGCCTGGACGTGTTCCGCTACCTGTCGCCGCGCAGCGTGCGC
CCGCATCGGGAGGCCGCGTA

Downstream 100 bases:

>100_bases
GGTATCCCTTCTCCCACCGGGACATCGTGCTCCTTCATGGAGAGAAGGTGCCCGAAGAGGCGGATGAGGGGACGTGCGAA
GCCACATGCACTTCGAACAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRPAQASIDLEALRHNYRLAKRLGGSKALAVVKADAYGHGAVRCAQALEPEADGFAVACIEEALELRQAGIRAPILLLEG
FFEHDELRLIAEHDLWTVAATPQQVRALAEFQSPRPLRVWLKLDSGMHRLGLSPEDFRAAWLRLRGLPQIASLVLMTHLA
RADELDCSRTDEQAVAFALTAGGMRAETSLRNSPGLLGWPALRNDWSRPGLMLYGANPFPQDTENTAQLRPVMTLRSRII
SVRELPAGEPVGYGARFVAERPTRVGVVAMGYADGYPQFAPNGTPVLVDGQVCPLAGRVSMDMLTVDLTDHPQADIGTPV
QLWGDAPQVGALAAQCNVSAYQLLCGLKRVPRVYMGEAAAKEGVTR

Sequences:

>Translated_366_residues
MRPAQASIDLEALRHNYRLAKRLGGSKALAVVKADAYGHGAVRCAQALEPEADGFAVACIEEALELRQAGIRAPILLLEG
FFEHDELRLIAEHDLWTVAATPQQVRALAEFQSPRPLRVWLKLDSGMHRLGLSPEDFRAAWLRLRGLPQIASLVLMTHLA
RADELDCSRTDEQAVAFALTAGGMRAETSLRNSPGLLGWPALRNDWSRPGLMLYGANPFPQDTENTAQLRPVMTLRSRII
SVRELPAGEPVGYGARFVAERPTRVGVVAMGYADGYPQFAPNGTPVLVDGQVCPLAGRVSMDMLTVDLTDHPQADIGTPV
QLWGDAPQVGALAAQCNVSAYQLLCGLKRVPRVYMGEAAAKEGVTR
>Mature_366_residues
MRPAQASIDLEALRHNYRLAKRLGGSKALAVVKADAYGHGAVRCAQALEPEADGFAVACIEEALELRQAGIRAPILLLEG
FFEHDELRLIAEHDLWTVAATPQQVRALAEFQSPRPLRVWLKLDSGMHRLGLSPEDFRAAWLRLRGLPQIASLVLMTHLA
RADELDCSRTDEQAVAFALTAGGMRAETSLRNSPGLLGWPALRNDWSRPGLMLYGANPFPQDTENTAQLRPVMTLRSRII
SVRELPAGEPVGYGARFVAERPTRVGVVAMGYADGYPQFAPNGTPVLVDGQVCPLAGRVSMDMLTVDLTDHPQADIGTPV
QLWGDAPQVGALAAQCNVSAYQLLCGLKRVPRVYMGEAAAKEGVTR

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=360, Percent_Identity=46.6666666666667, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1787439, Length=356, Percent_Identity=45.7865168539326, Blast_Score=288, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_XANAC (Q8PGD0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643994.1
- ProteinModelPortal:   Q8PGD0
- SMR:   Q8PGD0
- GeneID:   1157758
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3687
- NMPDR:   fig|190486.1.peg.3638
- HOGENOM:   HBG712172
- OMA:   FEHDELR
- ProtClustDB:   PRK00053
- BioCyc:   XAXO190486:XAC3687-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39756; Mature: 39756

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 33-33 ACT_SITE 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAQASIDLEALRHNYRLAKRLGGSKALAVVKADAYGHGAVRCAQALEPEADGFAVACI
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCEEHHHH
EEALELRQAGIRAPILLLEGFFEHDELRLIAEHDLWTVAATPQQVRALAEFQSPRPLRVW
HHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCEEEEECCHHHHHHHHHHCCCCCEEEE
LKLDSGMHRLGLSPEDFRAAWLRLRGLPQIASLVLMTHLARADELDCSRTDEQAVAFALT
EEECCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEE
AGGMRAETSLRNSPGLLGWPALRNDWSRPGLMLYGANPFPQDTENTAQLRPVMTLRSRII
CCCCCCCCCCCCCCCCEECHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SVRELPAGEPVGYGARFVAERPTRVGVVAMGYADGYPQFAPNGTPVLVDGQVCPLAGRVS
HHHHCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCE
MDMLTVDLTDHPQADIGTPVQLWGDAPQVGALAAQCNVSAYQLLCGLKRVPRVYMGEAAA
EEEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCHHH
KEGVTR
HCCCCC
>Mature Secondary Structure
MRPAQASIDLEALRHNYRLAKRLGGSKALAVVKADAYGHGAVRCAQALEPEADGFAVACI
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCEEHHHH
EEALELRQAGIRAPILLLEGFFEHDELRLIAEHDLWTVAATPQQVRALAEFQSPRPLRVW
HHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCEEEEECCHHHHHHHHHHCCCCCEEEE
LKLDSGMHRLGLSPEDFRAAWLRLRGLPQIASLVLMTHLARADELDCSRTDEQAVAFALT
EEECCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEE
AGGMRAETSLRNSPGLLGWPALRNDWSRPGLMLYGANPFPQDTENTAQLRPVMTLRSRII
CCCCCCCCCCCCCCCCEECHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
SVRELPAGEPVGYGARFVAERPTRVGVVAMGYADGYPQFAPNGTPVLVDGQVCPLAGRVS
HHHHCCCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCE
MDMLTVDLTDHPQADIGTPVQLWGDAPQVGALAAQCNVSAYQLLCGLKRVPRVYMGEAAA
EEEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCHHH
KEGVTR
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217