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The map label for this gene is wzt [H]

Identifier: 21244325

GI number: 21244325

Start: 4271662

End: 4272891

Strand: Reverse

Name: wzt [H]

Synonym: XAC3600

Alternate gene names: 21244325

Gene position: 4272891-4271662 (Counterclockwise)

Preceding gene: 21244326

Following gene: 21244324

Centisome position: 82.56

GC content: 55.61

Gene sequence:

>1230_bases
ATGACTAGCACTGCGCTTCCCCAAATTCCAGATAACAAGCTTGCGCTTGAGATGCGTGGAGTTACCAAGGACTACCCAGT
CTATGGGCATCCTCTCAAGCGTCTATTCTCGTTGTTGCGCCCATCGGGTGATCGTGCATCCCACAACTTTCGCGCGCTGG
AGGATATAACCCTCCTTGTACCAAGGGGCGAAACCGTCGGCATCATCGGTCGGAACGGTGCCGGAAAATCGACCCTTCTA
CAGATCCTGTGCGGCACGCTTTCGCCGACCAAGGGCACTGTCCGCATACGGGGGCGTTTTGCGGCACTGCTGGAGTTGGG
GGCCGGCTTCAACCCTGACTTCAGCGGCCGTGAGAACGTCTATCTCAGCGCGTCTCTGCTTGGCCTGACTCATGCGGAAG
TCGATCAAAGCCTGGACAAGATCATTGAGTTCGCCGATATCGGTGAATTCATCGACCGCCCGGTCAAGACCTATTCCAGC
GGCATGTACGTGCGGCTGGCTTTTTCCGTCGCCATTCACACAGAGCCTGACGTGCTGATCATCGACGAGGCACTGTCTGT
GGGTGATATCCGCTTTCAGATAAAGTGTCTGGCGCGAATCGAGCAGATCCGCGCGCGTGGAGCCACCGTCCTGTTTGTCT
CGCATTCGCTGGAGCAGGTGAAGCGGTTCTGCCAAACCGCGATCTGGCTCGAGCAGGGGCAGGTGAAATTGCATGGCGAG
GCGAGTTTTGTCGCGGACCGGTTTCGGGACTACGAACTGGGACGACTGGCGCCCCCGTCAGGCGAAGCGAATCTAGTTGC
GGAAAAGTCTCCTGCAAAAAGAGATTCGGTCCCCGCTCACATCGAGCGTACGACGATGTCTACCGACATGTTGGCGCCCT
TTGAACCTTTGACAGTCGAGATCGAATACGCGGTCAATGACGACATGATCGATGGCTTGCTCTTGGGCGTTGCAATAAAA
GGCCTGGATGGTCAGCACATCTTTGGCCCGAATACGCATCTTGAGCAGATCGATATTCCTGCTAGCCGTGGAACTCACGG
TATTACGTACCACATTCCTTCCATGCCGTTGTTAACAGGCACATATCGCATCGATGTCGGTCTTTTTACCGATAAGGGCC
TGGTGTGCTTGGATTACCTGTCTTCGGTAAATGAGTTCACCGTCGCTGCGCCGTACTTCAGCGAGGGGCTGGTCTATATT
TCTCATGAGTGGCGTGTCCATGGGCGTTGA

Upstream 100 bases:

>100_bases
ACTTGGTGTCGCTTGGAAATCATTTCGTAATTTCCATCATCGCTGCGCTGCTGGCGTACGCGCTTTTCAAGCGTCTATCA
CGAGGTTTTGCGGACGTCCT

Downstream 100 bases:

>100_bases
TCTCCAAGCCATCGCGTTTGATCATTACCAGCGCTACGGCGCGGCTTCTGCGATATTGAGCACGCTGGGCTGCGGCGATT
GCTGGATACTCGAAGTCGGT

Product: ABC transporter ATP-binding protein

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTSTALPQIPDNKLALEMRGVTKDYPVYGHPLKRLFSLLRPSGDRASHNFRALEDITLLVPRGETVGIIGRNGAGKSTLL
QILCGTLSPTKGTVRIRGRFAALLELGAGFNPDFSGRENVYLSASLLGLTHAEVDQSLDKIIEFADIGEFIDRPVKTYSS
GMYVRLAFSVAIHTEPDVLIIDEALSVGDIRFQIKCLARIEQIRARGATVLFVSHSLEQVKRFCQTAIWLEQGQVKLHGE
ASFVADRFRDYELGRLAPPSGEANLVAEKSPAKRDSVPAHIERTTMSTDMLAPFEPLTVEIEYAVNDDMIDGLLLGVAIK
GLDGQHIFGPNTHLEQIDIPASRGTHGITYHIPSMPLLTGTYRIDVGLFTDKGLVCLDYLSSVNEFTVAAPYFSEGLVYI
SHEWRVHGR

Sequences:

>Translated_409_residues
MTSTALPQIPDNKLALEMRGVTKDYPVYGHPLKRLFSLLRPSGDRASHNFRALEDITLLVPRGETVGIIGRNGAGKSTLL
QILCGTLSPTKGTVRIRGRFAALLELGAGFNPDFSGRENVYLSASLLGLTHAEVDQSLDKIIEFADIGEFIDRPVKTYSS
GMYVRLAFSVAIHTEPDVLIIDEALSVGDIRFQIKCLARIEQIRARGATVLFVSHSLEQVKRFCQTAIWLEQGQVKLHGE
ASFVADRFRDYELGRLAPPSGEANLVAEKSPAKRDSVPAHIERTTMSTDMLAPFEPLTVEIEYAVNDDMIDGLLLGVAIK
GLDGQHIFGPNTHLEQIDIPASRGTHGITYHIPSMPLLTGTYRIDVGLFTDKGLVCLDYLSSVNEFTVAAPYFSEGLVYI
SHEWRVHGR
>Mature_408_residues
TSTALPQIPDNKLALEMRGVTKDYPVYGHPLKRLFSLLRPSGDRASHNFRALEDITLLVPRGETVGIIGRNGAGKSTLLQ
ILCGTLSPTKGTVRIRGRFAALLELGAGFNPDFSGRENVYLSASLLGLTHAEVDQSLDKIIEFADIGEFIDRPVKTYSSG
MYVRLAFSVAIHTEPDVLIIDEALSVGDIRFQIKCLARIEQIRARGATVLFVSHSLEQVKRFCQTAIWLEQGQVKLHGEA
SFVADRFRDYELGRLAPPSGEANLVAEKSPAKRDSVPAHIERTTMSTDMLAPFEPLTVEIEYAVNDDMIDGLLLGVAIKG
LDGQHIFGPNTHLEQIDIPASRGTHGITYHIPSMPLLTGTYRIDVGLFTDKGLVCLDYLSSVNEFTVAAPYFSEGLVYIS
HEWRVHGR

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI31657092, Length=227, Percent_Identity=29.9559471365639, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI153792144, Length=229, Percent_Identity=25.764192139738, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI27881501, Length=209, Percent_Identity=24.4019138755981, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI30795238, Length=209, Percent_Identity=24.4019138755981, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI150417984, Length=208, Percent_Identity=26.4423076923077, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI6005701, Length=216, Percent_Identity=25.462962962963, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI105990541, Length=246, Percent_Identity=24.390243902439, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI27477115, Length=216, Percent_Identity=25.462962962963, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI116734710, Length=210, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI45446740, Length=210, Percent_Identity=25.2380952380952, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI47078218, Length=210, Percent_Identity=25.2380952380952, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=27.3584905660377, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI27262624, Length=211, Percent_Identity=23.2227488151659, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI27262626, Length=211, Percent_Identity=23.2227488151659, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI21536376, Length=213, Percent_Identity=26.2910798122066, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI21729873, Length=205, Percent_Identity=25.8536585365854, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI15149474, Length=205, Percent_Identity=25.8536585365854, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI21729876, Length=205, Percent_Identity=25.8536585365854, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1789891, Length=216, Percent_Identity=30.0925925925926, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081709, Length=244, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786398, Length=293, Percent_Identity=27.6450511945392, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787089, Length=224, Percent_Identity=25.8928571428571, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786703, Length=223, Percent_Identity=29.1479820627803, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790467, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081782, Length=229, Percent_Identity=25.3275109170306, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI48994943, Length=207, Percent_Identity=29.4685990338164, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790739, Length=207, Percent_Identity=27.536231884058, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788210, Length=191, Percent_Identity=30.8900523560209, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788761, Length=201, Percent_Identity=25.3731343283582, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786319, Length=196, Percent_Identity=26.0204081632653, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081791, Length=200, Percent_Identity=23, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788897, Length=221, Percent_Identity=25.7918552036199, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788165, Length=178, Percent_Identity=27.5280898876405, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48995001, Length=199, Percent_Identity=26.6331658291457, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082268, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789593, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082267, Length=194, Percent_Identity=23.7113402061856, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=208, Percent_Identity=27.4038461538462, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789032, Length=201, Percent_Identity=23.3830845771144, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1790525, Length=215, Percent_Identity=25.1162790697674, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=211, Percent_Identity=27.4881516587678, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI115533608, Length=211, Percent_Identity=23.696682464455, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17510237, Length=208, Percent_Identity=24.5192307692308, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565938, Length=213, Percent_Identity=29.1079812206573, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007184, Length=184, Percent_Identity=27.7173913043478, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221500365, Length=184, Percent_Identity=27.7173913043478, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24643674, Length=312, Percent_Identity=23.3974358974359, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573571, Length=225, Percent_Identity=22.6666666666667, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573573, Length=225, Percent_Identity=22.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648314, Length=196, Percent_Identity=27.0408163265306, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512771, Length=213, Percent_Identity=25.3521126760563, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574150, Length=234, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007328, Length=234, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666092, Length=235, Percent_Identity=22.1276595744681, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 45044; Mature: 44913

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTALPQIPDNKLALEMRGVTKDYPVYGHPLKRLFSLLRPSGDRASHNFRALEDITLLV
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
PRGETVGIIGRNGAGKSTLLQILCGTLSPTKGTVRIRGRFAALLELGAGFNPDFSGRENV
ECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEECHHHEEHHHHCCCCCCCCCCCCCE
YLSASLLGLTHAEVDQSLDKIIEFADIGEFIDRPVKTYSSGMYVRLAFSVAIHTEPDVLI
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEE
IDEALSVGDIRFQIKCLARIEQIRARGATVLFVSHSLEQVKRFCQTAIWLEQGQVKLHGE
EECCCCCCCEEEEHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHEEECCEEEEECC
ASFVADRFRDYELGRLAPPSGEANLVAEKSPAKRDSVPAHIERTTMSTDMLAPFEPLTVE
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEE
IEYAVNDDMIDGLLLGVAIKGLDGQHIFGPNTHLEQIDIPASRGTHGITYHIPSMPLLTG
EEEECCCHHHHHHEEEHEEECCCCCEEECCCCCCEEEECCCCCCCCCEEEECCCCCEEEE
TYRIDVGLFTDKGLVCLDYLSSVNEFTVAAPYFSEGLVYISHEWRVHGR
EEEEEEEEECCCCCHHHHHHHCCCCEEEECCHHHCCEEEEEEEEEECCC
>Mature Secondary Structure 
TSTALPQIPDNKLALEMRGVTKDYPVYGHPLKRLFSLLRPSGDRASHNFRALEDITLLV
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
PRGETVGIIGRNGAGKSTLLQILCGTLSPTKGTVRIRGRFAALLELGAGFNPDFSGRENV
ECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEECHHHEEHHHHCCCCCCCCCCCCCE
YLSASLLGLTHAEVDQSLDKIIEFADIGEFIDRPVKTYSSGMYVRLAFSVAIHTEPDVLI
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCEEE
IDEALSVGDIRFQIKCLARIEQIRARGATVLFVSHSLEQVKRFCQTAIWLEQGQVKLHGE
EECCCCCCCEEEEHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHEEECCEEEEECC
ASFVADRFRDYELGRLAPPSGEANLVAEKSPAKRDSVPAHIERTTMSTDMLAPFEPLTVE
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEE
IEYAVNDDMIDGLLLGVAIKGLDGQHIFGPNTHLEQIDIPASRGTHGITYHIPSMPLLTG
EEEECCCHHHHHHEEEHEEECCCCCEEECCCCCCEEEECCCCCCCCCEEEECCCCCEEEE
TYRIDVGLFTDKGLVCLDYLSSVNEFTVAAPYFSEGLVYISHEWRVHGR
EEEEEEEEECCCCCHHHHHHHCCCCEEEECCHHHCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]