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The map label for this gene is rmlB [H]

Identifier: 21244310

GI number: 21244310

Start: 4251173

End: 4252228

Strand: Reverse

Name: rmlB [H]

Synonym: XAC3585

Alternate gene names: 21244310

Gene position: 4252228-4251173 (Counterclockwise)

Preceding gene: 21244322

Following gene: 21244309

Centisome position: 82.16

GC content: 62.41

Gene sequence:

>1056_bases
GTGGCAATTTGGCTAGTAACCGGCGGTGCCGGCTTCATCGGTGGCAACTTTGTTCTTGAAGCAGTGGCTCGCGGAGTGCG
TGTGGTCAATCTTGACGCGCTGACCTATGCGGGAAATCTGAACACATTGGCTCCCCTGGAGGGCAACCCGGACCATGTCT
TCGTCAAGGGCGACATTGGCGACCGCGCGTTAGTCGCCAGTCTGCTGCACGAACACCAGCCCGATGCAGTGCTGAATTTC
GCAGCCGAGAGCCATGTGGATCGCTCGATCGAAGGCCCGGGCGCGTTCATCCAGACCAATGTGGTCGGGACCCTGGCCCT
GCTTGAAGCGGTCCGTGACCACTGGAAGGCGCTGCCGAAGGAGCGCCAGGATGCGTTCCGGTTTCTGCACGTGTCCACCG
ATGAGGTCTACGGCACGTTGGGCGAGACCGGCAAGTTCACCGAAACCACGCCGTACGCGCCCAACTCGCCGTACTCCGCG
TCGAAAGCCGCTTCCGATCACCTGGTACGTGCGTTCCACCACACCTACGGTCTGCCGGTGCTGACCACCAATTGTTCGAA
CAATTATGGCCCGTACCACTTTCCAGAAAAGCTCATTCCGCTGGTAATCGCCAAAGCGCTCGCTGGCGAGCCACTGCCGG
TCTACGGCGATGGCAAGCAGGTACGCGACTGGCTGTTCGTCAGCGATCACTGCGAAGCGATCCGCACCGTGCTGGCCAAG
GGCAAGGTCGGCGAGACCTACAACGTGGGCGGCAACTCCGAGCGCCAGAACATCGAGGTCGTGCAGGCGATCTGTGCGCT
GCTGGATCAGCATCGCCCGCGTGAAGACGGCAAGCCGCGCGCGAGCCAGATCACCCATGTCACCGACCGCCCCGGACACG
ACCGTCGCTACGCGATCGATGCCTCCAAGTTGAAGAACGACCTGGGCTGGGAGCCGGCGTATACCTTCGAGCAAGGTATC
GCGCAGACGGTGGAGTGGTACCTGACCAACCAGGCCTGGGTGCAGGGCGTGCTGGATGGCAGCTATCGGCTGGAACGGAT
CGGCGCCGCGGCCTAA

Upstream 100 bases:

>100_bases
ACGGGTTGCTGCGACCACTTAGCCTCCATACCTGTCTGGACCGTATATCCTGTGTCGTTTGAACACGCAGCGCGGTTCGC
GCGCGACAAGGAGATCGGCA

Downstream 100 bases:

>100_bases
CGCGAGCCATTAGCAAGAGCCCGCGCATGCATGCGTGTGCGGGCCTCCAACAGGACATACCTGATGACACAACGTAAAGG
CATCATTCTGGCGGGCGGCT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MAIWLVTGGAGFIGGNFVLEAVARGVRVVNLDALTYAGNLNTLAPLEGNPDHVFVKGDIGDRALVASLLHEHQPDAVLNF
AAESHVDRSIEGPGAFIQTNVVGTLALLEAVRDHWKALPKERQDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSA
SKAASDHLVRAFHHTYGLPVLTTNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAK
GKVGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRASQITHVTDRPGHDRRYAIDASKLKNDLGWEPAYTFEQGI
AQTVEWYLTNQAWVQGVLDGSYRLERIGAAA

Sequences:

>Translated_351_residues
MAIWLVTGGAGFIGGNFVLEAVARGVRVVNLDALTYAGNLNTLAPLEGNPDHVFVKGDIGDRALVASLLHEHQPDAVLNF
AAESHVDRSIEGPGAFIQTNVVGTLALLEAVRDHWKALPKERQDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSA
SKAASDHLVRAFHHTYGLPVLTTNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAK
GKVGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRASQITHVTDRPGHDRRYAIDASKLKNDLGWEPAYTFEQGI
AQTVEWYLTNQAWVQGVLDGSYRLERIGAAA
>Mature_350_residues
AIWLVTGGAGFIGGNFVLEAVARGVRVVNLDALTYAGNLNTLAPLEGNPDHVFVKGDIGDRALVASLLHEHQPDAVLNFA
AESHVDRSIEGPGAFIQTNVVGTLALLEAVRDHWKALPKERQDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSAS
KAASDHLVRAFHHTYGLPVLTTNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAKG
KVGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRASQITHVTDRPGHDRRYAIDASKLKNDLGWEPAYTFEQGIA
QTVEWYLTNQAWVQGVLDGSYRLERIGAAA

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=36.1702127659575, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI42516563, Length=330, Percent_Identity=24.5454545454545, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4504031, Length=342, Percent_Identity=26.0233918128655, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI56237023, Length=358, Percent_Identity=25.9776536312849, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI56118217, Length=358, Percent_Identity=25.9776536312849, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI189083684, Length=358, Percent_Identity=25.9776536312849, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994969, Length=353, Percent_Identity=59.7733711048159, Blast_Score=423, Evalue=1e-120,
Organism=Escherichia coli, GI1788353, Length=349, Percent_Identity=58.7392550143267, Blast_Score=416, Evalue=1e-118,
Organism=Escherichia coli, GI1786974, Length=348, Percent_Identity=28.1609195402299, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788366, Length=350, Percent_Identity=27.7142857142857, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=36.4179104477612, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI115532424, Length=338, Percent_Identity=33.7278106508876, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=25.5131964809384, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=343, Percent_Identity=25.3644314868805, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=343, Percent_Identity=25.3644314868805, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=343, Percent_Identity=25.3644314868805, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=343, Percent_Identity=25.3644314868805, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=372, Percent_Identity=26.8817204301075, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=343, Percent_Identity=23.9067055393586, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=330, Percent_Identity=23.030303030303, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=360, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19923002, Length=362, Percent_Identity=28.1767955801105, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356223, Length=329, Percent_Identity=24.3161094224924, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24158427, Length=292, Percent_Identity=26.027397260274, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38403; Mature: 38271

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIWLVTGGAGFIGGNFVLEAVARGVRVVNLDALTYAGNLNTLAPLEGNPDHVFVKGDIG
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEECCCCCCCCEEEEECCCC
DRALVASLLHEHQPDAVLNFAAESHVDRSIEGPGAFIQTNVVGTLALLEAVRDHWKALPK
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCH
ERQDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSASKAASDHLVRAFHHTYGLPV
HHHHHHHEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LTTNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAK
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHEEEHHHHHHHHHHHHC
GKVGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRASQITHVTDRPGHDRRYAID
CCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEE
ASKLKNDLGWEPAYTFEQGIAQTVEWYLTNQAWVQGVLDGSYRLERIGAAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure 
AIWLVTGGAGFIGGNFVLEAVARGVRVVNLDALTYAGNLNTLAPLEGNPDHVFVKGDIG
EEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEECCCCCCCCEEEEECCCC
DRALVASLLHEHQPDAVLNFAAESHVDRSIEGPGAFIQTNVVGTLALLEAVRDHWKALPK
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCH
ERQDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSASKAASDHLVRAFHHTYGLPV
HHHHHHHEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LTTNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAK
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHEEEHHHHHHHHHHHHC
GKVGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRASQITHVTDRPGHDRRYAID
CCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEE
ASKLKNDLGWEPAYTFEQGIAQTVEWYLTNQAWVQGVLDGSYRLERIGAAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]