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The map label for this gene is rmlA [H]

Identifier: 21244309

GI number: 21244309

Start: 4250222

End: 4251142

Strand: Reverse

Name: rmlA [H]

Synonym: XAC3584

Alternate gene names: 21244309

Gene position: 4251142-4250222 (Counterclockwise)

Preceding gene: 21244310

Following gene: 21244308

Centisome position: 82.14

GC content: 59.5

Gene sequence:

>921_bases
ATGCGTGTGCGGGCCTCCAACAGGACATACCTGATGACACAACGTAAAGGCATCATTCTGGCGGGCGGCTCGGGCACGCG
CCTGTACCCGATCACCAAGGGCGTCAGCAAGCAGCTGCTGCCGGTGTACGACAAGCCGATGATCTATTATCCGCTGAGCG
TGCTGATGCTCGCGGGGATTCGCGACATCCTGATCATCAACACGCCGCACGAGCAGGCGCTGTTCCAGTCGCTGTTGGGC
GATGGCTCGCAGTGGGGAGTCAACATTCAATACGCCGTGCAGCCCAGCCCGGATGGGTTGGCGCAGGCCTATCTGATCGG
GCGCGAGTTCGTCGACGGCAAGCCGAGTTGCCTGGTGTTGGGCGACAATATTTTCCATGGGCATGGCCTGACCGACACCT
TGCGGCGCGCCGATGCGCGTGAGCAGGGCGCCACCGTCTTCGGTTACTGGGTCAACGATCCTGAGCGCTATGGCGTGGCC
GAATTCGATCAGCAGGGCAAGGTCATCGATATTGCCGAAAAGCCTGCAAAGCCCCGCTCCAACTATGCGGTCACCGGCCT
GTACTTCTACGATGGAAAAGCCAGCGATTATGCGGCTGCCTTGAAACCTTCTCCGCGTGGCGAGCTGGAGATTACCGATC
TCAATCGCTGCTATCTCGATGCTGGTGAGCTGCATCTTGAGCCGCTGGGGCGCGGGTATGCATGGCTGGATACCGGAACG
CACCAGTCGTTGCATGAAGCGGCCAATTTCATCGAGACCATCCAGATGCGTCAGGGCCTGCAGGTGTGCTGCCCCGAAGA
AATTGCGTTCGGTCAGGGCTGGATCGATGCGGAACAACTGGAACGGCTGGCCGCCCCATTGCTGAAAAACGACTATGGCA
AGTATCTGCACGAATTGGCTGTGCGAGGAGTAGTACCGTGA

Upstream 100 bases:

>100_bases
CAACCAGGCCTGGGTGCAGGGCGTGCTGGATGGCAGCTATCGGCTGGAACGGATCGGCGCCGCGGCCTAACGCGAGCCAT
TAGCAAGAGCCCGCGCATGC

Downstream 100 bases:

>100_bases
AAATCGTCGAAACCCGTTTACCAGGTTGTGTGGTCATCGAGCCGGCAGTGTTCGGCGATGAGCGCGGATATTTCTTTGAA
ACGTGGAATGCGGAGCGCTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRVRASNRTYLMTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLG
DGSQWGVNIQYAVQPSPDGLAQAYLIGREFVDGKPSCLVLGDNIFHGHGLTDTLRRADAREQGATVFGYWVNDPERYGVA
EFDQQGKVIDIAEKPAKPRSNYAVTGLYFYDGKASDYAAALKPSPRGELEITDLNRCYLDAGELHLEPLGRGYAWLDTGT
HQSLHEAANFIETIQMRQGLQVCCPEEIAFGQGWIDAEQLERLAAPLLKNDYGKYLHELAVRGVVP

Sequences:

>Translated_306_residues
MRVRASNRTYLMTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLG
DGSQWGVNIQYAVQPSPDGLAQAYLIGREFVDGKPSCLVLGDNIFHGHGLTDTLRRADAREQGATVFGYWVNDPERYGVA
EFDQQGKVIDIAEKPAKPRSNYAVTGLYFYDGKASDYAAALKPSPRGELEITDLNRCYLDAGELHLEPLGRGYAWLDTGT
HQSLHEAANFIETIQMRQGLQVCCPEEIAFGQGWIDAEQLERLAAPLLKNDYGKYLHELAVRGVVP
>Mature_306_residues
MRVRASNRTYLMTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGIRDILIINTPHEQALFQSLLG
DGSQWGVNIQYAVQPSPDGLAQAYLIGREFVDGKPSCLVLGDNIFHGHGLTDTLRRADAREQGATVFGYWVNDPERYGVA
EFDQQGKVIDIAEKPAKPRSNYAVTGLYFYDGKASDYAAALKPSPRGELEITDLNRCYLDAGELHLEPLGRGYAWLDTGT
HQSLHEAANFIETIQMRQGLQVCCPEEIAFGQGWIDAEQLERLAAPLLKNDYGKYLHELAVRGVVP

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=68.1660899653979, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1790224, Length=284, Percent_Identity=64.7887323943662, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788355, Length=240, Percent_Identity=25, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=190, Percent_Identity=27.8947368421053, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=193, Percent_Identity=29.0155440414508, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355443, Length=220, Percent_Identity=23.1818181818182, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24644084, Length=220, Percent_Identity=23.1818181818182, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33945; Mature: 33945

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRASNRTYLMTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGI
CEEECCCCEEEEEECCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCC
RDILIINTPHEQALFQSLLGDGSQWGVNIQYAVQPSPDGLAQAYLIGREFVDGKPSCLVL
CEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
GDNIFHGHGLTDTLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDIAEKPAKPRS
ECCEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCCCCEEEECCCCCCCCC
NYAVTGLYFYDGKASDYAAALKPSPRGELEITDLNRCYLDAGELHLEPLGRGYAWLDTGT
CEEEEEEEEECCCCCCEEEECCCCCCCCEEEEECCEEEECCCCEEEEECCCCEEEEECCC
HQSLHEAANFIETIQMRQGLQVCCPEEIAFGQGWIDAEQLERLAAPLLKNDYGKYLHELA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRGVVP
HHCCCC
>Mature Secondary Structure
MRVRASNRTYLMTQRKGIILAGGSGTRLYPITKGVSKQLLPVYDKPMIYYPLSVLMLAGI
CEEECCCCEEEEEECCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCC
RDILIINTPHEQALFQSLLGDGSQWGVNIQYAVQPSPDGLAQAYLIGREFVDGKPSCLVL
CEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEE
GDNIFHGHGLTDTLRRADAREQGATVFGYWVNDPERYGVAEFDQQGKVIDIAEKPAKPRS
ECCEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCCCCEEEECCCCCCCCC
NYAVTGLYFYDGKASDYAAALKPSPRGELEITDLNRCYLDAGELHLEPLGRGYAWLDTGT
CEEEEEEEEECCCCCCEEEECCCCCCCCEEEEECCEEEECCCCEEEEECCCCEEEEECCC
HQSLHEAANFIETIQMRQGLQVCCPEEIAFGQGWIDAEQLERLAAPLLKNDYGKYLHELA
HHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRGVVP
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]