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The map label for this gene is ilvG [H]

Identifier: 21244177

GI number: 21244177

Start: 4073227

End: 4074948

Strand: Direct

Name: ilvG [H]

Synonym: XAC3452

Alternate gene names: 21244177

Gene position: 4073227-4074948 (Clockwise)

Preceding gene: 21244176

Following gene: 21244178

Centisome position: 78.7

GC content: 66.84

Gene sequence:

>1722_bases
ATGAACACCTCCGCACACAGCACGCCCCGCAATGGCGCGCGCTGGCTGACGCAGGCCCTGGAAGCCGAAGGCGTGGAAAC
GCTGTTCGGCTATCCGGGCGGCACCATCATGCCGTTCTACGACGCCCTGGTGGATTCCAGGCTCAAGCACATCCTGGTTC
GTCACGAACAGGGCGCTGCACTGGCTGCCAACGGCTATGCCCGTGCCAGCGGCCGGGTCGGCGTGTGCGTGGCCACCTCC
GGCCCGGGCGCATCCAACCTGGTCACCGGCATCGCCGATGCGATGCTGGACTCGGTGCCGATGATCTGCCTGACCGGCCA
GGTCGCCACGCCGCTGCTGGGCACCGACGCATTCCAGGAGCTGGACGTGTTCGGCATGACCATGCCGATCGTCAAGCACA
GCTTCCTGGTGCGGCGTGTGGAGGAGCTTCCGGAGATGGTGCGCGAGGCGTTTCGCATTGCGCGCGAAGGGCGCCCTGGG
CCGGTGCTGATCGACCTGCCCAAGGACGTGCAGGTGGCCGACGCCTCGCATCTGCCCCTGCATGTTCCGGCAGCGGTGTC
GCCGCCGCCGGCGCCGGCGGACGCGAAACTGGCCGACGCGTTGGCAGCAATCGCCAGCGCCGAACGCCCGGTGGTGTACG
GCGGGGGCGGGATCGCGCTGGCCGGCGCGGTGGAAGCCTTCCGGCGTTTCGTCGAGGCCACCGGCATCCCGACCGCGCTG
ACCTTGCGCGGCCTGGGGGCATTACCGCATGCGCATCCGGACTATCTGGGCATGTTGGGCATGCACGGCACCCGTGCGGC
CAATATGGCCATCCAGGAATGCGATCTGCTGGTGGTGGTCGGTGCGCGTTTCGACGACCGTGCCACCGGCAAACTGAGCG
AGTTCGCACCGTTCGCACGCGTCATCCATCTGGATGCCGACGCATATGAGATCTCCAAGCTGCGCACCGCCGATATCGCG
GTGCCCGGCGACGTGGCAGTGAGTCTGAAAGCCTTGAGTGCGGCGCGCGGCAACTGCCAGGCCTGGCGCACGCGCTGTTT
CGCCAACCGCGAAAAGTTCGGCGCGCGTTACGACGCGCCCGGCACCGACATCTACGCACCGGCGCTATTGAAGCGCCTGA
GCGAAGTGGCTCCGGCCGACACCATCATCGCCTGCGATGTGGGTCAGCATCAGATGTGGGTGGCGCAGCATTGCCGCTTC
AACGACCCGCGCAATCACCTCACCAGCGGCGCGCTGGGCACCATGGGCTTCGGCCTGCCGGCCGCGATGGGCGCACAGTT
CGCCTGCCCTGACCGCACCGTGGTGCTAGTCTCCGGCGACGGCAGTTTCATGATGAACGTGCAGGAGCTGGTGACGATTG
CACGCTGCAAGCTGCCGGTGAAGATCGTGCTGCTGGACAACAGCTCGCTAGGCATGGTGCGGCAGTGGCAGGAACTGTTC
TTCGCCGAGCGTTACAGCGAAATCGACCTGTCCGACAACCCGGATTTTGCGGCGTTGGCGCACGTGTTCGGCATTCCGGC
CAAGCGCATCATCGCCCGCGGCGATGTGGACACGGCACTGGCCGACTTGCTGGCGCAGCCCGGTCCCGGCCTGCTGCATG
TCGCGATCGACGCGCGTGCCAATGTGTGGCCGCTGGTGCCGCCCAACAACGCCAACAGCACCATGCTGGACAGCAATCCC
GCACATGCGGCCAAGGAGACATCGCATGCGTTACCGGCTTGA

Upstream 100 bases:

>100_bases
GTGTGGCTCAACGGGCAACAGCAAGCCGCTGCCGCACCTGCGAATCAACAGGCGGCATAACGCCGCCTCCCCCACCGCTT
AAACCGAAGGTCCGCAACGC

Downstream 100 bases:

>100_bases
TCTGGTGCTGAAGCCGGCAGAAGGCGCATTGGTGCGGGTGATCGGCATGACCGAACGCCGCGGCTTCCGCCCATGCGCGA
TCCAGGGCGCAGCAGCGCCA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MNTSAHSTPRNGARWLTQALEAEGVETLFGYPGGTIMPFYDALVDSRLKHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLVTGIADAMLDSVPMICLTGQVATPLLGTDAFQELDVFGMTMPIVKHSFLVRRVEELPEMVREAFRIAREGRPG
PVLIDLPKDVQVADASHLPLHVPAAVSPPPAPADAKLADALAAIASAERPVVYGGGGIALAGAVEAFRRFVEATGIPTAL
TLRGLGALPHAHPDYLGMLGMHGTRAANMAIQECDLLVVVGARFDDRATGKLSEFAPFARVIHLDADAYEISKLRTADIA
VPGDVAVSLKALSAARGNCQAWRTRCFANREKFGARYDAPGTDIYAPALLKRLSEVAPADTIIACDVGQHQMWVAQHCRF
NDPRNHLTSGALGTMGFGLPAAMGAQFACPDRTVVLVSGDGSFMMNVQELVTIARCKLPVKIVLLDNSSLGMVRQWQELF
FAERYSEIDLSDNPDFAALAHVFGIPAKRIIARGDVDTALADLLAQPGPGLLHVAIDARANVWPLVPPNNANSTMLDSNP
AHAAKETSHALPA

Sequences:

>Translated_573_residues
MNTSAHSTPRNGARWLTQALEAEGVETLFGYPGGTIMPFYDALVDSRLKHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLVTGIADAMLDSVPMICLTGQVATPLLGTDAFQELDVFGMTMPIVKHSFLVRRVEELPEMVREAFRIAREGRPG
PVLIDLPKDVQVADASHLPLHVPAAVSPPPAPADAKLADALAAIASAERPVVYGGGGIALAGAVEAFRRFVEATGIPTAL
TLRGLGALPHAHPDYLGMLGMHGTRAANMAIQECDLLVVVGARFDDRATGKLSEFAPFARVIHLDADAYEISKLRTADIA
VPGDVAVSLKALSAARGNCQAWRTRCFANREKFGARYDAPGTDIYAPALLKRLSEVAPADTIIACDVGQHQMWVAQHCRF
NDPRNHLTSGALGTMGFGLPAAMGAQFACPDRTVVLVSGDGSFMMNVQELVTIARCKLPVKIVLLDNSSLGMVRQWQELF
FAERYSEIDLSDNPDFAALAHVFGIPAKRIIARGDVDTALADLLAQPGPGLLHVAIDARANVWPLVPPNNANSTMLDSNP
AHAAKETSHALPA
>Mature_573_residues
MNTSAHSTPRNGARWLTQALEAEGVETLFGYPGGTIMPFYDALVDSRLKHILVRHEQGAALAANGYARASGRVGVCVATS
GPGASNLVTGIADAMLDSVPMICLTGQVATPLLGTDAFQELDVFGMTMPIVKHSFLVRRVEELPEMVREAFRIAREGRPG
PVLIDLPKDVQVADASHLPLHVPAAVSPPPAPADAKLADALAAIASAERPVVYGGGGIALAGAVEAFRRFVEATGIPTAL
TLRGLGALPHAHPDYLGMLGMHGTRAANMAIQECDLLVVVGARFDDRATGKLSEFAPFARVIHLDADAYEISKLRTADIA
VPGDVAVSLKALSAARGNCQAWRTRCFANREKFGARYDAPGTDIYAPALLKRLSEVAPADTIIACDVGQHQMWVAQHCRF
NDPRNHLTSGALGTMGFGLPAAMGAQFACPDRTVVLVSGDGSFMMNVQELVTIARCKLPVKIVLLDNSSLGMVRQWQELF
FAERYSEIDLSDNPDFAALAHVFGIPAKRIIARGDVDTALADLLAQPGPGLLHVAIDARANVWPLVPPNNANSTMLDSNP
AHAAKETSHALPA

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=562, Percent_Identity=25.0889679715303, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21361361, Length=520, Percent_Identity=27.5, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1790104, Length=563, Percent_Identity=45.4706927175844, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI87081685, Length=553, Percent_Identity=42.49547920434, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786717, Length=474, Percent_Identity=32.7004219409283, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1787096, Length=539, Percent_Identity=28.7569573283859, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788716, Length=545, Percent_Identity=26.2385321100917, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17542570, Length=505, Percent_Identity=28.5148514851485, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=28.3057851239669, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=28.3057851239669, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323755, Length=590, Percent_Identity=40.3389830508475, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320816, Length=478, Percent_Identity=24.0585774058577, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323073, Length=471, Percent_Identity=22.9299363057325, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=474, Percent_Identity=23.4177215189873, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922626, Length=496, Percent_Identity=28.2258064516129, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60775; Mature: 60775

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSAHSTPRNGARWLTQALEAEGVETLFGYPGGTIMPFYDALVDSRLKHILVRHEQGAA
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
LAANGYARASGRVGVCVATSGPGASNLVTGIADAMLDSVPMICLTGQVATPLLGTDAFQE
EEECCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHH
LDVFGMTMPIVKHSFLVRRVEELPEMVREAFRIAREGRPGPVLIDLPKDVQVADASHLPL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCE
HVPAAVSPPPAPADAKLADALAAIASAERPVVYGGGGIALAGAVEAFRRFVEATGIPTAL
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEE
TLRGLGALPHAHPDYLGMLGMHGTRAANMAIQECDLLVVVGARFDDRATGKLSEFAPFAR
HHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCEEE
VIHLDADAYEISKLRTADIAVPGDVAVSLKALSAARGNCQAWRTRCFANREKFGARYDAP
EEEECCCHHHHHHHCEECEECCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHCCCCCCCC
GTDIYAPALLKRLSEVAPADTIIACDVGQHQMWVAQHCRFNDPRNHLTSGALGTMGFGLP
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCHHHCCCCH
AAMGAQFACPDRTVVLVSGDGSFMMNVQELVTIARCKLPVKIVLLDNSSLGMVRQWQELF
HHHCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
FAERYSEIDLSDNPDFAALAHVFGIPAKRIIARGDVDTALADLLAQPGPGLLHVAIDARA
HHHHHCCCCCCCCCCHHHHHHHHCCCHHHHEECCCHHHHHHHHHHCCCCCEEEEEEECCC
NVWPLVPPNNANSTMLDSNPAHAAKETSHALPA
CEECCCCCCCCCCCEECCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MNTSAHSTPRNGARWLTQALEAEGVETLFGYPGGTIMPFYDALVDSRLKHILVRHEQGAA
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
LAANGYARASGRVGVCVATSGPGASNLVTGIADAMLDSVPMICLTGQVATPLLGTDAFQE
EEECCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHH
LDVFGMTMPIVKHSFLVRRVEELPEMVREAFRIAREGRPGPVLIDLPKDVQVADASHLPL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCE
HVPAAVSPPPAPADAKLADALAAIASAERPVVYGGGGIALAGAVEAFRRFVEATGIPTAL
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEE
TLRGLGALPHAHPDYLGMLGMHGTRAANMAIQECDLLVVVGARFDDRATGKLSEFAPFAR
HHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCEEE
VIHLDADAYEISKLRTADIAVPGDVAVSLKALSAARGNCQAWRTRCFANREKFGARYDAP
EEEECCCHHHHHHHCEECEECCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHCCCCCCCC
GTDIYAPALLKRLSEVAPADTIIACDVGQHQMWVAQHCRFNDPRNHLTSGALGTMGFGLP
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCHHHCCCCH
AAMGAQFACPDRTVVLVSGDGSFMMNVQELVTIARCKLPVKIVLLDNSSLGMVRQWQELF
HHHCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
FAERYSEIDLSDNPDFAALAHVFGIPAKRIIARGDVDTALADLLAQPGPGLLHVAIDARA
HHHHHCCCCCCCCCCHHHHHHHHCCCHHHHEECCCHHHHHHHHHHCCCCCEEEEEEECCC
NVWPLVPPNNANSTMLDSNPAHAAKETSHALPA
CEECCCCCCCCCCCEECCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]