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The map label for this gene is ilvC

Identifier: 21244176

GI number: 21244176

Start: 4072185

End: 4073186

Strand: Direct

Name: ilvC

Synonym: XAC3451

Alternate gene names: 21244176

Gene position: 4072185-4073186 (Clockwise)

Preceding gene: 21244173

Following gene: 21244177

Centisome position: 78.68

GC content: 62.87

Gene sequence:

>1002_bases
ATGAGCAACCACACCCAACCGAAAATCGCGATCATCGGCTACGGCAGCCAGGGCCGCGCACATGCGCTGAACCTGCGCGA
TTCCGGCTTCGACGTCACCGTCGGCCTGCGTCCCGGTGGCCCGACCGAGGCCAAGGCGCAGGCCGATGGCTTCACCGTCG
TGGCGCCGTCCGAGGCGGTCAAGAGTGCTGACCTGGTCGCCATCCTGACCCCGGACATGGTGCAGAAGAAGCTCTACGAA
GAGGTCATCGCCCCGAACATGAAGCAGGGCGCCTGCCTGCTGTTCGCGCATGGCCTGAACGTGCATTTCGACATGATCAC
CCCGCGCGCCGATCTGGACGTGGTGCTGGTCGCGCCCAAGGGCCCGGGCGCATTGGTACGTCGCGAATATGAAATCGGCC
GCGGCGTGCCGTGCATCTATGCGGTCTACCAGGACACCAGCGGCAAGGCCGAGCAGTTCGCGTTGACCTATGCCGGCGGC
CTGGGCGGCGCGCGCGCCAACATCATCAAGACCACGTTCAAGGAAGAAACCGAAACCGATCTGTTCGGCGAGCAGGCCGT
GCTGTGCGGCGGCGCCTCCTCGCTGGTGCAGGCCGGTTTCGAAGTGCTGGTCGAGGCCGGCTATCAGCCGGAAATCGCAT
ACTACGAAGTGCTGCACGAATTGAAGTTGATCGTGGACCTGTTCTACGAAGGCGGCATCACCCGTATGCTGGAATTCGTT
TCCGAAACCGCGCAATACGGCGATTATGTCAGCGGCCCGCGCGTGATCGATGCCGGCACCAAGGCGCGCATGAAGGATGT
GCTGACCGACATCCAGAACGGCACCTTCACCAAGAACTGGGTGGCCGAATACGACGCCGGCCTGCCGAACTACAACAAGT
TCAAGCAGGCCGATCTGGAGCACCCGATCGAGGAAGTGGGCAAGAAGCTGCGCGCCAAGATGGTGTGGCTCAACGGGCAA
CAGCAAGCCGCTGCCGCACCTGCGAATCAACAGGCGGCATAA

Upstream 100 bases:

>100_bases
CATCGCTCGTCCCCGCTTTGCTCAGCCGGCCAGTGCACGCACTGCCGGCTGATCCATTTATCCACTGCCCATCTCCACTG
CCAACCCGCAAGGACATTCC

Downstream 100 bases:

>100_bases
CGCCGCCTCCCCCACCGCTTAAACCGAAGGTCCGCAACGCATGAACACCTCCGCACACAGCACGCCCCGCAATGGCGCGC
GCTGGCTGACGCAGGCCCTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSNHTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPSEAVKSADLVAILTPDMVQKKLYE
EVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGG
LGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
SETAQYGDYVSGPRVIDAGTKARMKDVLTDIQNGTFTKNWVAEYDAGLPNYNKFKQADLEHPIEEVGKKLRAKMVWLNGQ
QQAAAAPANQQAA

Sequences:

>Translated_333_residues
MSNHTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPSEAVKSADLVAILTPDMVQKKLYE
EVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGG
LGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
SETAQYGDYVSGPRVIDAGTKARMKDVLTDIQNGTFTKNWVAEYDAGLPNYNKFKQADLEHPIEEVGKKLRAKMVWLNGQ
QQAAAAPANQQAA
>Mature_332_residues
SNHTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPSEAVKSADLVAILTPDMVQKKLYEE
VIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGL
GGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFVS
ETAQYGDYVSGPRVIDAGTKARMKDVLTDIQNGTFTKNWVAEYDAGLPNYNKFKQADLEHPIEEVGKKLRAKMVWLNGQQ
QAAAAPANQQAA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=288, Percent_Identity=35.4166666666667, Blast_Score=148, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=330, Percent_Identity=32.7272727272727, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_XANAC (Q8PH09)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643758.1
- ProteinModelPortal:   Q8PH09
- SMR:   Q8PH09
- GeneID:   1157522
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3451
- NMPDR:   fig|190486.1.peg.3402
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   XAXO190486:XAC3451-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35988; Mature: 35857

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: ACT_SITE 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPSEAV
CCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHH
KSADLVAILTPDMVQKKLYEEVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPK
CCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCCCCCEEEECCC
GPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETD
CCCHHHEEEHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
LFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
HCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SETAQYGDYVSGPRVIDAGTKARMKDVLTDIQNGTFTKNWVAEYDAGLPNYNKFKQADLE
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHC
HPIEEVGKKLRAKMVWLNGQQQAAAAPANQQAA
CHHHHHHHHHHEEEEEECCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SNHTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTEAKAQADGFTVVAPSEAV
CCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHH
KSADLVAILTPDMVQKKLYEEVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPK
CCCCEEEEECHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCCCCCEEEECCC
GPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETD
CCCHHHEEEHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHH
LFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFV
HCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SETAQYGDYVSGPRVIDAGTKARMKDVLTDIQNGTFTKNWVAEYDAGLPNYNKFKQADLE
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHC
HPIEEVGKKLRAKMVWLNGQQQAAAAPANQQAA
CHHHHHHHHHHEEEEEECCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217