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The map label for this gene is pepQ

Identifier: 21244128

GI number: 21244128

Start: 4010533

End: 4011858

Strand: Direct

Name: pepQ

Synonym: XAC3403

Alternate gene names: 21244128

Gene position: 4010533-4011858 (Clockwise)

Preceding gene: 21244127

Following gene: 21244129

Centisome position: 77.49

GC content: 66.37

Gene sequence:

>1326_bases
ATGCCCCAGCCCTCCCTGAGCAGCCTGTACTCCGACCACCTGCGCACCCTCACCGCGCGCGCCGACGAAGCGCTGCAACG
CGGCGGTTTCGAGCATCTGGTGGTTCCCAGCGGCAGCACGCATTACCAGCTGTTCGACGACCGCGATTACCCCTACGCGG
TGAACCCGCAGTTCAAGGCCTGGGTACCGCTGACACGGGTCCCCGACAGCTGGCTGGTCTACACGCCGGGCAAGCGCCCG
ACGGTGATCTTCTATCAGCCGTTCGACTACTGGCATGTGGTGCCCGACGCGCCCAGCGGCTGGTGGGTCGATCACTGCGA
CATCCACATCATCCGCACCCCGGACCAGGCGCTGGCGCTGCTGCCCAAACACGCTGAGCGCTGCGCGATTCTCGGCGAGC
CACACAGCACGCTCGGTGCGTATGTGCCGAACAACCCGCAGCCGGTGCTCGATTACCTGGAATACCAGCGCGCGTTCAAG
ACGCCCTACGAGCTGGCATTGCTGCGCATCGCCCAGCAACTGGCGGTGCGCGGCCATCGCGCTGCGGAAGCAGCGTTCCG
CGCCGGACAGAGCGAATTCGGCATCCACATGGCGTATTGCGCGGCAGTGGGCCAGGACGCCAATGACTTGCCGTACGGCA
ACATCATCGCGCTCAACGAACACGGCGCGGTGCTGCACTACACCGAACTGGGCCAGCAGCCGCCGCAACCGCTGCGTAGC
TTCCTGATCGACGCCGGCGCTTCCGCATACGGCTACGCCAGCGACATCACCCGCACCTACGCGGCCGACCCCGACAGCGA
CTTTCAGGCGCTGATCGATGCAGTGGATGCCGCCCAGCTGCGCATGGGCCAGAACGTGCGCGCCGGCGTGGACTACAAGC
AGCTGCACATCGACGCGCATCTGGCGTTGATGGGCATCCTCAAGGAGTTCGGCATCCTGACCGTCTCGCCGGAAGCGGCC
TTGGCCACCGGCGTCAGCGCTGCGTTCTTCCCGCACGGCCTGGGCCATCTGATCGGCCTGCAAGTGCACGATGTGGCCGG
TTTTGCCGCCAGCGACCGCGGCGGCCGCATCGAACGCCCGCCCGGCCACCCGTATTTGCGCCTGACCCGCGTGCTGGAGC
CCGGCATGGTGGTCACGATCGAGCCTGGCGTGTACTTCATCGACATGCTGCTGGACGAAGTGAAGAAGAACGGCCACGCC
GCCAGCGTCGACTGGCAGCGCGTGGAAGCGTTCAAGCCATACGGCGGCATTCGCATCGAAGATGAGGTGGTGTGCACCGA
CGGCAGCGCGGAAAATCTGACCCGCCCGGTCTTCGCCGCCGCATGA

Upstream 100 bases:

>100_bases
TGACGATTGCACCTTGGTTGTCGGCCATGCAAGGACACAGCGCCATTGCAGGGATTGCGGCAAACTGCGCATCGCCTTTG
CATTGCCGATCGAGCCCCGC

Downstream 100 bases:

>100_bases
GCATCAGGCGCGCCTGACCACGCCACGGTTGGAGTCCCGGGCCGGCATGGCCAACGCCTGAAGGGGCTATCAGCCGCGCC
ATCCACCACCCGATCACGCC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKAWVPLTRVPDSWLVYTPGKRP
TVIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPDQALALLPKHAERCAILGEPHSTLGAYVPNNPQPVLDYLEYQRAFK
TPYELALLRIAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRS
FLIDAGASAYGYASDITRTYAADPDSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIDAHLALMGILKEFGILTVSPEAA
LATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERPPGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHA
ASVDWQRVEAFKPYGGIRIEDEVVCTDGSAENLTRPVFAAA

Sequences:

>Translated_441_residues
MPQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKAWVPLTRVPDSWLVYTPGKRP
TVIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPDQALALLPKHAERCAILGEPHSTLGAYVPNNPQPVLDYLEYQRAFK
TPYELALLRIAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRS
FLIDAGASAYGYASDITRTYAADPDSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIDAHLALMGILKEFGILTVSPEAA
LATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERPPGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHA
ASVDWQRVEAFKPYGGIRIEDEVVCTDGSAENLTRPVFAAA
>Mature_440_residues
PQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKAWVPLTRVPDSWLVYTPGKRPT
VIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPDQALALLPKHAERCAILGEPHSTLGAYVPNNPQPVLDYLEYQRAFKT
PYELALLRIAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRSF
LIDAGASAYGYASDITRTYAADPDSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIDAHLALMGILKEFGILTVSPEAAL
ATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERPPGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAA
SVDWQRVEAFKPYGGIRIEDEVVCTDGSAENLTRPVFAAA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily

Homologues:

Organism=Homo sapiens, GI149589008, Length=291, Percent_Identity=36.0824742268041, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI260593665, Length=291, Percent_Identity=36.0824742268041, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI260593663, Length=246, Percent_Identity=37.3983739837398, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI11559925, Length=318, Percent_Identity=26.4150943396226, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790282, Length=436, Percent_Identity=47.0183486238532, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1789275, Length=288, Percent_Identity=30.5555555555556, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=291, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321118, Length=302, Percent_Identity=30.794701986755, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=310, Percent_Identity=25.4838709677419, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357079, Length=291, Percent_Identity=35.3951890034364, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19920384, Length=300, Percent_Identity=29.3333333333333, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPQ_XANAC (Q8PH57)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643710.1
- HSSP:   P81535
- ProteinModelPortal:   Q8PH57
- MEROPS:   M24.003
- GeneID:   1157474
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3403
- NMPDR:   fig|190486.1.peg.3354
- HOGENOM:   HBG296884
- OMA:   PYGNIVA
- ProtClustDB:   PRK13607
- BioCyc:   XAXO190486:XAC3403-MONOMER
- BRENDA:   3.4.13.9
- GO:   GO:0006508
- HAMAP:   MF_01279
- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.13.9

Molecular weight: Translated: 48552; Mature: 48421

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCEEECCCCEE
WVPLTRVPDSWLVYTPGKRPTVIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPDQALAL
EECCCCCCCCCEEECCCCCCEEEEECCCCEEEEECCCCCCCEEECCEEEEEECCHHHHHH
LPKHAERCAILGEPHSTLGAYVPNNPQPVLDYLEYQRAFKTPYELALLRIAQQLAVRGHR
HHCCCCCEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
AAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRS
HHHHHHHCCCCCCCEEEEEHHHHCCCCCCCCCCCEEEECCCCCEEEEHHHCCCCCHHHHH
FLIDAGASAYGYASDITRTYAADPDSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIDAH
HHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
LALMGILKEFGILTVSPEAALATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERP
HHHHHHHHHCCEEEECCCHHHHHCCHHHHHHCCHHHHCCEEEECCCCEEECCCCCCCCCC
PGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAASVDWQRVEAFKPYGGIRIE
CCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCEECCCHHHHHHCCCCCCEEEC
DEVVCTDGSAENLTRPVFAAA
CEEEECCCCHHHCCCCHHHCC
>Mature Secondary Structure 
PQPSLSSLYSDHLRTLTARADEALQRGGFEHLVVPSGSTHYQLFDDRDYPYAVNPQFKA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCEEECCCCEE
WVPLTRVPDSWLVYTPGKRPTVIFYQPFDYWHVVPDAPSGWWVDHCDIHIIRTPDQALAL
EECCCCCCCCCEEECCCCCCEEEEECCCCEEEEECCCCCCCEEECCEEEEEECCHHHHHH
LPKHAERCAILGEPHSTLGAYVPNNPQPVLDYLEYQRAFKTPYELALLRIAQQLAVRGHR
HHCCCCCEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCH
AAEAAFRAGQSEFGIHMAYCAAVGQDANDLPYGNIIALNEHGAVLHYTELGQQPPQPLRS
HHHHHHHCCCCCCCEEEEEHHHHCCCCCCCCCCCEEEECCCCCEEEEHHHCCCCCHHHHH
FLIDAGASAYGYASDITRTYAADPDSDFQALIDAVDAAQLRMGQNVRAGVDYKQLHIDAH
HHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
LALMGILKEFGILTVSPEAALATGVSAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIERP
HHHHHHHHHCCEEEECCCHHHHHCCHHHHHHCCHHHHCCEEEECCCCEEECCCCCCCCCC
PGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAASVDWQRVEAFKPYGGIRIE
CCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCEECCCHHHHHHCCCCCCEEEC
DEVVCTDGSAENLTRPVFAAA
CEEEECCCCHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217