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The map label for this gene is mazG [H]

Identifier: 21243792

GI number: 21243792

Start: 3586074

End: 3587093

Strand: Reverse

Name: mazG [H]

Synonym: XAC3065

Alternate gene names: 21243792

Gene position: 3587093-3586074 (Counterclockwise)

Preceding gene: 77748692

Following gene: 21243791

Centisome position: 69.31

GC content: 65.88

Gene sequence:

>1020_bases
ATGCCTCAGACCCCATCCATCGGCGATATCCAGCAGCTGTTGCACGTGATGGCGCGTCTGCGCGATCGCGAACACGGCTG
TCCCTGGGATGTGCAGCAGACCTTCGCCAGCATCGCGCCCTACACCATCGAAGAAGCCTACGAGGTGGCCGATGCGATCG
ATCGCAACGACCTGGCTGGCCTGCGCGACGAGTTGGGCGACCTGTTGCTGCAGGTGGTCTTCCATTCGCAAATGGCGGCC
GAGCAGGGGGCGTTTACATTCGCCGACGTGGTCGCCACGCTTCGCGACAAGCTCATACGCCGCCACCCGCATGTGTTCGC
CGCGCAACCGGCGGCCGATGCGCAGGCGGTGAGCGCCAACTGGGAGCAGATCAAGCGCGAAGAACGTCGTGCTGCCGGCA
ACCAAGACGACTCCGCACTTGCCGGCATCGCGCGCGGGCTGCCCGAATGGCAGCGCTCCACCAAACTGCAGTCGCGTGCG
GCGCGCGTGGGTTTCGATTGGCCCGGCCCGGCGCCGGTGCTGGAAAAACTGCAGGAAGAAATCGAAGAGTTGCGCGTGGA
ATTCGCACGCGGCCCGGTGGCCGACAATCAGGCCCGGCTGGAAGACGAACTGGGCGATGTGTTGTTCGTCTGCGCCAATC
TGGCGCGCCATGCCAAGGTGGATGTCGGCGCCGCGTTGCGGCACGCCAACCTGAAATTCGAACGTCGCTTTCGTGCGATG
GAAGCGCAGGCGCGTACTGCCGGCACCTCGTTGAACGCGTTGTCGCTGGGCGAGCAGGAAGCGTTGTGGCAACAGGCCAA
GCGTGAGGAGCGCAGCGGCGATGTGCGGGTCGTCGACAGTCCGGCCATCGACGGTTCCGCGGGCGATGCATCGGCCTTGC
ACGCCCCGGTGTCCCACGCGCCGCCCGTGGACAGCCCTGTCAGCAGTCACCCGTCCGTTGGCGGTGAGGTTTTCCGCAGC
GCAATGGGGTATCAAACCGGCGTCGATGGCCCCGATTCCGAAACGCCGCGCCCCGCATGA

Upstream 100 bases:

>100_bases
GCGTGCCGCGTCTATTGCGGGTGCAACGGCCGCTTACGTCGCTTACGTCGCGTGGGAATGCGCTGGCGGCGCACCCACTC
ACAGGTTCCAGGAATACACG

Downstream 100 bases:

>100_bases
CGATCGCGCCGACCACGCTGCTGTTGTTCGCCGCGACGGCGCTCGCCGAGTTGGTGGGTTGCTACCTTCCTTATCTCTGG
CTGCGCAAAGGTGGCAGCGT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPQTPSIGDIQQLLHVMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAA
EQGAFTFADVVATLRDKLIRRHPHVFAAQPAADAQAVSANWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRA
ARVGFDWPGPAPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
EAQARTAGTSLNALSLGEQEALWQQAKREERSGDVRVVDSPAIDGSAGDASALHAPVSHAPPVDSPVSSHPSVGGEVFRS
AMGYQTGVDGPDSETPRPA

Sequences:

>Translated_339_residues
MPQTPSIGDIQQLLHVMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAA
EQGAFTFADVVATLRDKLIRRHPHVFAAQPAADAQAVSANWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRA
ARVGFDWPGPAPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
EAQARTAGTSLNALSLGEQEALWQQAKREERSGDVRVVDSPAIDGSAGDASALHAPVSHAPPVDSPVSSHPSVGGEVFRS
AMGYQTGVDGPDSETPRPA
>Mature_338_residues
PQTPSIGDIQQLLHVMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAAE
QGAFTFADVVATLRDKLIRRHPHVFAAQPAADAQAVSANWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAA
RVGFDWPGPAPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAME
AQARTAGTSLNALSLGEQEALWQQAKREERSGDVRVVDSPAIDGSAGDASALHAPVSHAPPVDSPVSSHPSVGGEVFRSA
MGYQTGVDGPDSETPRPA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=264, Percent_Identity=53.4090909090909, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 36952; Mature: 36820

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTPSIGDIQQLLHVMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHSQMAAEQGAFTFADVVATLRDKLIRRHPHVFAAQPAADAQAVSAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHCC
WEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAARVGFDWPGPAPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EAQARTAGTSLNALSLGEQEALWQQAKREERSGDVRVVDSPAIDGSAGDASALHAPVSHA
HHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
PPVDSPVSSHPSVGGEVFRSAMGYQTGVDGPDSETPRPA
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQTPSIGDIQQLLHVMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHSQMAAEQGAFTFADVVATLRDKLIRRHPHVFAAQPAADAQAVSAN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHCC
WEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAARVGFDWPGPAPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EAQARTAGTSLNALSLGEQEALWQQAKREERSGDVRVVDSPAIDGSAGDASALHAPVSHA
HHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCC
PPVDSPVSSHPSVGGEVFRSAMGYQTGVDGPDSETPRPA
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]