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The map label for this gene is lysA [H]

Identifier: 21243638

GI number: 21243638

Start: 3417751

End: 3420360

Strand: Reverse

Name: lysA [H]

Synonym: XAC2911

Alternate gene names: 21243638

Gene position: 3420360-3417751 (Counterclockwise)

Preceding gene: 21243641

Following gene: 21243637

Centisome position: 66.09

GC content: 66.05

Gene sequence:

>2610_bases
ATGTCAGCTCCCCACTCTACCGATCGTTGGATCGTCCTCAAGTTCGGCGGCACTTCGGTGTCGCGTCGTCATCGCTGGGA
CACGATTGGAAAACTGGCGAGCAAACGGGCGAACGAAACCGGCGGCCGCGTGCTGGTGGTGGTGTCTGCATTGTCGGGCG
TGACCAACGAGCTCACCGCCATTGCCGACGGCGCCGCCGATAGCGCGCAGCGCGTGGCGGCACTGGACCAACGCCATCGC
GAGTTTCTGGCCGAGCTCGAACTGGACGCCGATGCAGTGCTGGGCGAGCGCCTGGCCGCACTGCACGCATTGCTGGGCGA
TGCGCGCGCTGCAACGCGCACGCTGGATTGGCAAGCCGAGGTGCTGGGGCAGGGCGAGTTACTGTCGTCCACCATCGGCG
CGGCGTATCTGCATGCCAGCGGCCTGGACATGGGGTGGCTGGATGCGCGCCAGTGGCTGTCCGCACTGCCGCCGCAGCCC
AATCAGAGCGAATGGTCCAAGCGGCTGTCGGTCTCGTGCCAATGGCAGTCCGATGCCGATTGGCGCACGCGTTTCGCCGC
GCAACCGACACGCTTGCTGATCACGCAAGGCTTCATTTCGCGTCATGCCGATGGCGGCACCGCGATTCTGGGCCGTGGCG
GTTCGGATACCTCGGCGGCGTACTTCGGCGCGCTGCTCGGCGCCAGCCGGGTGGAAATCTGGACCGACGTGCCTGGCATG
TTCAGCGCCAACCCGAAAGAAGTGCCGGATGCGCGGCTGCTGACCCGGCTGGACTATTACGAAGCGCAGGAAATCGCCAC
CACCGGCGCCAAGGTGCTGCATCCGCGCTCGATCAAGCCGTGCCGCGATTCCGGCGTGCCGATGGCGATTCTGGACACCG
AGCGCCCGGATCTGCCGGGTACCAGCATCGACGGCAATGCCGAGCTGGTGCTGGGCGTCAAGGCGATCAGCCGCCGCAAT
GGCATCGTGCTGGTGTCGATGGAAGGCATCGGCATGTGGCAGCAGGTCGGCTTCCTGGCCGACGTGTTCACGCTGTTCAA
GAAGCACGGCCTGTCGGTGGACTTGATCGGTTCGGCCGAGACCAACGTCACCGTGTCGCTGGATCCTTCGGAAAACCTGG
TCAACACCGATGTGCTGGCGGCGTTGTCGGCCGATCTTTCGCAGATCTGCAAGGTCAAGATCATCGTTCCTTGCGCGGCC
ATCACCTTGGTCGGACGCGGCATGCGTTCGCTGCTGCACAAGCTCTCCGACGTGTGGGCCACGTTCGGGCAGGAACGCGT
GCACATGATTTCGCAGTCGTCCAACGACTTGAACCTGACCTTCGTCATCGACGAAGCCGATGCCGACGGTTTGCTGCCGA
TCCTGCACGCGGAACTGATCGACAGCGGTGCGATGCCGGTCAGCGAGGGCGAGGTGTTCGGGCCGCGCTGGCGGCAGATC
ATCGGCTCGGTACGTCCCCGACCCACGCCGTGGTGGCATGCCGAGCGCGCGCATCTGCTGTCGCTGTCCAGGGCCGGGAC
GCCGCGTTACGCATACCACCTGCCCACGGTGCGTGAGCGTGCGCATGCGCTGGCGCAGATAGCCGCGGTGGATCAGCGCT
ATTACGCGATCAAGGCCAATGCGCATCCGGCCATCCTGATGGCGCTGGAGCAGGCCGGCTTCGGGCTGGAATGCGTCTCG
CACGGCGAATTGCGCCGCGTATTCCAGGCGCTGCCGGAGCTGTCGCCACGGCGCGTGCTGTTCACGCCGAGCTTTGCGCC
CAAGGCCGAATACGAAGCGGCCTTCGCGCTGGGCGTGACGGTGACCGTGGACAACGTCGAGGCGCTGCGCAACTGGCCCG
AGGTGTTCCGTGGCCGCAATGTGTGGCTGCGCATCGACCTGGGGCACGGCGACGGCCATCACGAGAAGGTCAACACCGGC
GGCAAGGCTTCCAAGTTCGGCCTGTCGTCCACGCGGGTGGATGAATTTGTCGAGGTGGCGCGCACGCTCGAGGTCACCAT
CACCGGCGTGCATGCGCACCTGGGCAGTGGCGTGGAGACCGGCGAGCACTGGCGGATGATGTACGACGAGTTGGCCGGCT
TCGCGCGCCGTATCGGCACGGTGGAGACCATCGACATCGGTGGCGGCCTGCCGATTCCGTACAGCGCCGAAGACGAGCCA
TTCGATCTGGAGGTGTGGGCCAAGGGCCTGGCCGAGGTCAAGGCCGTGCATCCGGGCTACCGCCTGGCGATCGAGCCGGG
CCGCTATCTGGTGGCCGAAGCCGGCGTATTGCTCGCAAGCGTCACCCAGGTGATCGAGAAGGACGGCGTGCACCGCGTGG
GCCTGGATGCGGGGATGAATACCCTGATTCGCCCGGCGTTGTACGACGCCGGGCACGACATCGAAAACCTCAGCCAACTC
GACGCGCCGGCCGATGGCACGTTCGATATCGTCGGGCCGATCTGCGAATCGTCGGACGTGTTCGGCAAGCGCCGCCGCCT
GCCGGCGGCCACCGCACCAGGCGACGTGGTGCTGGTCGCCGATGCCGGCGCCTATGGCTACTCGATGGCCAGCACCTACA
ACCAGCGCGAATTGCCGCGCGAAGAGGTGATCGATGCGCCCACTGGCTGA

Upstream 100 bases:

>100_bases
AGTGATCGGACGCGGGGTCATGCGAGCGGCATTGGCAGTAGAATCGGAGGTTCCGCTCGGCATCCCGGGCATCTTCCCCC
CATCCTAAACGCCTATCTCA

Downstream 100 bases:

>100_bases
GTTCGTCGTACTCAGCACGCTGGCCGGTGGCGTGGCGATGGTGTTCTCCACCGCCATCGACATGGCCGGGCAACGGGTGC
CGTGGACCGACAGCCTGCGG

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 869; Mature: 868

Protein sequence:

>869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLGDARAATRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQP
NQSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAELVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
IGSVRPRPTPWWHAERAHLLSLSRAGTPRYAYHLPTVRERAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGELRRVFQALPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRNVWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVEVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAGHDIENLSQL
DAPADGTFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYSMASTYNQRELPREEVIDAPTG

Sequences:

>Translated_869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLGDARAATRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQP
NQSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAELVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
IGSVRPRPTPWWHAERAHLLSLSRAGTPRYAYHLPTVRERAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGELRRVFQALPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRNVWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVEVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAGHDIENLSQL
DAPADGTFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYSMASTYNQRELPREEVIDAPTG
>Mature_868_residues
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALDQRHRE
FLAELELDADAVLGERLAALHALLGDARAATRTLDWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPN
QSEWSKRLSVSCQWQSDADWRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGMF
SANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAELVLGVKAISRRNG
IVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAI
TLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQII
GSVRPRPTPWWHAERAHLLSLSRAGTPRYAYHLPTVRERAHALAQIAAVDQRYYAIKANAHPAILMALEQAGFGLECVSH
GELRRVFQALPELSPRRVLFTPSFAPKAEYEAAFALGVTVTVDNVEALRNWPEVFRGRNVWLRIDLGHGDGHHEKVNTGG
KASKFGLSSTRVDEFVEVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEPF
DLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMNTLIRPALYDAGHDIENLSQLD
APADGTFDIVGPICESSDVFGKRRRLPAATAPGDVVLVADAGAYGYSMASTYNQRELPREEVIDAPTG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=383, Percent_Identity=34.7258485639687, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=30.4157549234136, Blast_Score=176, Evalue=8e-45,
Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=30.398322851153, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1790376, Length=328, Percent_Identity=32.0121951219512, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320893, Length=514, Percent_Identity=26.6536964980545, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24586472, Length=347, Percent_Identity=27.0893371757925, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586474, Length=362, Percent_Identity=25.414364640884, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 94087; Mature: 93956

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTA
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLGDARAATRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPNQSEWSKRLSVSCQWQSDAD
HCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCEEEEEECCCCC
WRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAELVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCEEEEEEEHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
IGSVRPRPTPWWHAERAHLLSLSRAGTPRYAYHLPTVRERAHALAQIAAVDQRYYAIKAN
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGELRRVFQALPELSPRRVLFTPSFAPKAEYEAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALRNWPEVFRGRNVWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVEVA
EEECCHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
TLIRPALYDAGHDIENLSQLDAPADGTFDIVGPICESSDVFGKRRRLPAATAPGDVVLVA
HHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYSMASTYNQRELPREEVIDAPTG
CCCCCCCHHHHCCCHHCCCHHHHCCCCCC
>Mature Secondary Structure 
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLGDARAATRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPNQSEWSKRLSVSCQWQSDAD
HCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCEEEEEECCCCC
WRTRFAAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAELVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCEEEEEEEHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDEADADGLLPILHAELIDSGAMPVSEGEVFGPRWRQI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
IGSVRPRPTPWWHAERAHLLSLSRAGTPRYAYHLPTVRERAHALAQIAAVDQRYYAIKAN
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGELRRVFQALPELSPRRVLFTPSFAPKAEYEAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALRNWPEVFRGRNVWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVEVA
EEECCHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLEVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
TLIRPALYDAGHDIENLSQLDAPADGTFDIVGPICESSDVFGKRRRLPAATAPGDVVLVA
HHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYSMASTYNQRELPREEVIDAPTG
CCCCCCCHHHHCCCHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]