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The map label for this gene is yveA [H]

Identifier: 21243275

GI number: 21243275

Start: 2996252

End: 2997838

Strand: Reverse

Name: yveA [H]

Synonym: XAC2542

Alternate gene names: 21243275

Gene position: 2997838-2996252 (Counterclockwise)

Preceding gene: 21243276

Following gene: 21243274

Centisome position: 57.92

GC content: 64.65

Gene sequence:

>1587_bases
ATGACCACACACGCTGCGACCACGCAAGGCAAGTTCCACAAGCGCCTCAGCCTGACCGACCTGACCTTTATCGGGCTGGG
TTCGATCTTCGGTTCCGGGTGGTTGTTTTCGGCCAGCCACGTCTCATCGATCGCGGGGCCGGCCGGCATCGTGTCGTGGA
TCCTCGGTGGGATCGCGGTGCTGCTGCTTGGGCTGGTGTATTGCGAACTCGGCGCGGCATTGCCGCGCGCCGGCGGGGTG
GTGCGCTACCCGGAATATTCGCATGGCGCCTTGCTCGGTTCGCTGACCGGCTTCATCACCTTGATCGCGTTCTCCAGCCT
GATCGCGATCGAAGTGGAAGCGGCGCGGCAATACGCAGCGGCGTGGTTCCCGTGGTTGAGCCAGCCGAACAGCACCCATC
CCAGCGTCGTGGGTTGGCTGGTGCAGCTGGCCTTGCTGGTGCTGTTCTTCGTACTCAACTATTTCAGCGTCAAGACCTTT
GCGCTGGCCAATAACATCGTCAGCATCTTCAAGTTCCTGGTGCCGATCCTGGTGATCGTGCTGCTGATGCAGCACTTCGA
TGCCGGCAATCTGAGCGTGCATGGGTTCGCGCCATCGGGCATGGCGGGCGTGGAGGCGGCGATCTCGGCCGGCGGCATCA
TCTTCGCGTATCTGGGGTTGACCCCGATCGTGTCGGTGGCCAGTGAGGTGCGCGACCTGCAGCGCAATATTCCAATTGCG
CTGATCCTGTCGGTGGCGCTGTCCACGGCGATTTACGTGCTGCTGCAGCTGGCGTTCCTGGGCAGCATCCCGGCCGCGCA
ACTCGCGCAAGGCTGGGCGGGCATCGACAAGGCCTTCTCGCTGCCGTACCACGACATCGCCCTGGCCTTGGGCATGGCGT
GGCTGGCCGCGCTGGTGATCTGCGATGCGATGGTGTCGCCCAGCGGCACCGGCAACATCTACATGAATGCCACGCCGCGC
GTGGTGTATGGCTGGGCACGCAGTGGCGGGTTCTTGCCGGTGCTGACGCGGGTGGATCCGGCGTCGGGCATCCCGCGTCC
GGCACTGTGGTTGAGCCTGGGCTTGTCGATCTTCTGGACGCTGCCGTTTCCCTCCTGGGAAACGCTGATCGGCGTGGTGT
CGGCCGCCTTGGTGCTGAGCTATGCGGTGGCGCCGATCACGGTGGCGGCTCTGCGCCGCAGCGCGCCGGACTTGCCGCGC
CCATTTTTCGTGCGTGGCCTGCCGGTATTTGGGCCGCTGTCGTTCATGGTGGCGGCGTTGATCGTGTACTGGTCCACCTG
GCCGACCTTGTCGTGGTTGCTCGGCTTGCAGGTGCTGGCGTTCGTGCTGTACGTGCTATTGCGCCTGCCTTCGCGCCAGG
GCCGCGCGCGCCTGGTGCGGCAGGTGCGCGCGTCGTTGTGGCTGATCGTGTTCTTCGTGCTGGTGATGCTGGTGTCGTGG
GCGGGTACGTTCGGCGGACATGGCTGGATTGCGCATCCCTTCGATACGTTGGGCGTGGCGGTCATCGCGTTGTGCATTTA
TCACTGGGGCGCACGCAGCGGTTTGCGCAGCGACGAGCTTGCGCTGGAGGAGGACGATGGTGAGTGA

Upstream 100 bases:

>100_bases
AGGCATCGGCAGAGGCGAAGGCCTCCGCCAGCGACTGACACGTGCGCGCACGTGATGGCTTTAAGAGCAGTACCGCGCTT
TCCACATTTCGGGGCGACGT

Downstream 100 bases:

>100_bases
TGCGCGCCGCAGCGCATTTGGTTTACGTCGGTGGTCTGCGTTGGTCGCCTACGGATTGGTGTTGTCGGGTGCTGTGCAGG
CTGCGCCCAGCGTTGCCGAT

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPNSTHPSVVGWLVQLALLVLFFVLNYFSVKTF
ALANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDLQRNIPIA
LILSVALSTAIYVLLQLAFLGSIPAAQLAQGWAGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPR
PFFVRGLPVFGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLLRLPSRQGRARLVRQVRASLWLIVFFVLVMLVSW
AGTFGGHGWIAHPFDTLGVAVIALCIYHWGARSGLRSDELALEEDDGE

Sequences:

>Translated_528_residues
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPNSTHPSVVGWLVQLALLVLFFVLNYFSVKTF
ALANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDLQRNIPIA
LILSVALSTAIYVLLQLAFLGSIPAAQLAQGWAGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPR
PFFVRGLPVFGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLLRLPSRQGRARLVRQVRASLWLIVFFVLVMLVSW
AGTFGGHGWIAHPFDTLGVAVIALCIYHWGARSGLRSDELALEEDDGE
>Mature_527_residues
TTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGVV
RYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPNSTHPSVVGWLVQLALLVLFFVLNYFSVKTFA
LANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDLQRNIPIAL
ILSVALSTAIYVLLQLAFLGSIPAAQLAQGWAGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPRV
VYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRP
FFVRGLPVFGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLLRLPSRQGRARLVRQVRASLWLIVFFVLVMLVSWA
GTFGGHGWIAHPFDTLGVAVIALCIYHWGARSGLRSDELALEEDDGE

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=437, Percent_Identity=24.7139588100687, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI7657591, Length=437, Percent_Identity=24.7139588100687, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=23.2183908045977, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33286428, Length=404, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI110347453, Length=353, Percent_Identity=25.4957507082153, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI186910308, Length=472, Percent_Identity=23.728813559322, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI186910306, Length=472, Percent_Identity=23.728813559322, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI186910304, Length=472, Percent_Identity=23.728813559322, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI258614005, Length=434, Percent_Identity=21.889400921659, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI258614003, Length=434, Percent_Identity=21.889400921659, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI71979932, Length=425, Percent_Identity=24.9411764705882, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258645169, Length=380, Percent_Identity=22.3684210526316, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790653, Length=384, Percent_Identity=23.6979166666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=361, Percent_Identity=24.6537396121884, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=415, Percent_Identity=26.2650602409639, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=410, Percent_Identity=25.1219512195122, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17531343, Length=454, Percent_Identity=25.7709251101322, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667468, Length=405, Percent_Identity=25.1851851851852, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24668806, Length=438, Percent_Identity=21.689497716895, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356285, Length=438, Percent_Identity=21.689497716895, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24668802, Length=438, Percent_Identity=21.689497716895, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651635, Length=413, Percent_Identity=23.9709443099274, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24651633, Length=413, Percent_Identity=23.9709443099274, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221512776, Length=425, Percent_Identity=22.3529411764706, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24666159, Length=425, Percent_Identity=22.3529411764706, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550968, Length=418, Percent_Identity=24.8803827751196, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921172, Length=418, Percent_Identity=24.8803827751196, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357367, Length=419, Percent_Identity=23.6276849642005, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641993, Length=397, Percent_Identity=24.6851385390428, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641995, Length=397, Percent_Identity=24.6851385390428, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221331183, Length=367, Percent_Identity=24.2506811989101, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647653, Length=367, Percent_Identity=24.2506811989101, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664379, Length=367, Percent_Identity=24.2506811989101, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56580; Mature: 56449

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPWLSQPNSTHPSVVGWLVQLALLVLFFVLNYFSVKTFALANNIVSIFKFLVPILVIV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDLQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LILSVALSTAIYVLLQLAFLGSIPAAQLAQGWAGIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRPFFVRGLPVFGPLSFMVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFVLYVLLRLPSRQGRARLVRQVRASLWLIVFFVLVMLVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLGVAVIALCIYHWGARSGLRSDELALEEDDGE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPWLSQPNSTHPSVVGWLVQLALLVLFFVLNYFSVKTFALANNIVSIFKFLVPILVIV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDLQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LILSVALSTAIYVLLQLAFLGSIPAAQLAQGWAGIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRPFFVRGLPVFGPLSFMVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFVLYVLLRLPSRQGRARLVRQVRASLWLIVFFVLVMLVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLGVAVIALCIYHWGARSGLRSDELALEEDDGE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]