Click here to switch to the map view.

The map label for this gene is ptpA [H]

Identifier: 21243274

GI number: 21243274

Start: 2993923

End: 2996262

Strand: Reverse

Name: ptpA [H]

Synonym: XAC2541

Alternate gene names: 21243274

Gene position: 2996262-2993923 (Counterclockwise)

Preceding gene: 21243275

Following gene: 21243273

Centisome position: 57.89

GC content: 65.47

Gene sequence:

>2340_bases
ATGGTGAGTGATGCGCGCCGCAGCGCATTTGGTTTACGTCGGTGGTCTGCGTTGGTCGCCTACGGATTGGTGTTGTCGGG
TGCTGTGCAGGCTGCGCCCAGCGTTGCCGATTACCAACGCTCGCTGGGTTTGCGCGAGCAGTGGATCACGCTGACAGAGA
ATGTCGCCTGGCCGGCGCAGTGGCAGGACGACGGAAGGTTCTACTACCGCAAGACAGTGCCGGGCGGCTTTGCGTTTGTC
AGTGCCGATGTGGCCACCTTGCAGAAGCAGCCGGCCTTCGATCAGGCGCGCCTGGCGCAGGGCCTGAGTGCGGCAACCGG
GAAACCGTATGCGCCGCTGCGTCTGCCGTTCGAGCAGTTTTCGTTTTCAACCGAGGGCGAACGCAGCGATGGCGCCATTG
TCTTCGCACTGGACGATGCGCCCTGGCGTTGCACGCTGACCACCTACCGCTGCGCGCCCGATGCACGGCTGCAGCCGACC
TCACGCCCACGCGGCTTCGGCGTGGTACGCGACCCGCTGGTGCCGGCCGACACCACGCCGCGTCGTTCGCCGGATGCCAA
GTGGGAGGTGCTGGCCGATGGCTGGAACCTGGTATTGCGTCATCTCGCCGATGGGCAGGTCACACGGCTCAGCAGCGACG
GCCGTGCCGATGATTATTTCGATCCGGAGAGCGTTGCCTGGTCGCCGGACTCGCGGCAGCTGGCGGTGTATCGCGTGCGT
CCGGGGCTGGCTCGCCGTATCACCCGCGTCGAAGCCGCGCCTGCCGGCGGTGGGCAACCGGTGGTGCATACCCAGTTGTA
TCCCAAGCCGGGCGATGCGGTGGATGTGGAGCGCCCGGTACTGTTTGCGCTGGACGGCACGCGTCGCGACGTGGACACGG
CGTTGTTCGACAACCCGTATTCGTTGTCGCCGCTGCAGTGGCGCAGCGACGGGCGCAGTGTCGCGTTCGAGTATGTGCAG
CGCGGCTTCCAGCGCATGCGCGTGATTGCGGTGGATGCAATCAGTGGGCGCGCGCGCGTGGCAGTCGGCGAAGACGCGCG
CACCTTCGTGTATGCCGACCGCAGCTTTCGCCACGACGTGGATGGGCGTGGCGATGAGGTGCTGTGGATTTCCGAGCGAG
ATGGCTGGCGGCACCTGTATCTGTTCGATGGACGCAGCGGCAAGGTGAAACGCCAGCTCACCCGCGGGCCGTGGGTGGTG
CGCGATGTGCTGCGCGTGGACGATGCGCAGCGCCGCATCTGGTTCACGGCCAGCGGGATGGACGCAGGCAAGGACCCGTA
CGACAGGCAGCTCTACAGCGTGGATTTCGACGGCCGCCGGTTGACCCGCTTGACCCACGCCGAGGCCGACCACGACGTGG
CGATTGCCGACGATGGCCTGCATTACGTCGACGTCTATTCGCGTCCAGACCTGCCGCCGGTGATGGAGCTGCGCGCCATC
GATGGCCAACTGCTGCATACCGTGGAGCGTGGCACGATCGACAGGCTGCAGGCCGCCGGCTGGCGCGCGCCGGAGACCTT
CGTAGCCAAGGGCCGCGATGGCACCAGCGACATCTGGGGCATGGTGGTGCGACCGCGCGACTACGACCCGCGCAAGACCT
ATCCGGTGATCGAAAACATCTATGCCGGGCCGCACGATTCCTTCGTGCCCAAGACGTTCTGGCCGTTCGGTTATCACTCC
GGCGGCGACAAGCAGATCGGCATGCAGGCGCAGGCCGATCTGGGTTTCATCGTGGTGATGATCGACGGCATGGGGACCGC
CAACCGCTCCAAGGCGTTTCATGATGTCGCGTGGAAAGACCTGGGCGATTCCGGGTTTGCCGACCGCATTGCATGGCATC
GTGCGCTGGCCGCCAAAGACCCGTCTTACGACATCAGTCGCGTCGGCATCTATGGTGCCTCGGCGGGGGGGCAGAGCACG
CTGGGGGCGCTCGAGCGTCATCCGGAGTTCTACAAGGTGGGCGTTGCGTTTGCCGGGTGCTACGACAACCGCATGGACAA
GATCAGCTGGAATGAGCAGTGGATGGGCTGGCCGGTGGATGCGCACTATGCAGAGGCGTCTGGCGTGGTCAATGCACGCA
AGCTGCAGGGCGACCTGCTGCTGATCGTCGGCGAGCAGGACAGCAATGTGGATCCGGCGTCCACCGCACAGGTCGTCGAT
GCCCTGATCAGGGCCGGCAAGGAGTTCGACCTGCTCAATGTGCCGGGTGGCGAACATTCGGTTGGCCGCTCCAGCGGGCC
GATCGATTACGTGCAACGTCGCCAGTACGACTTCTTCGTGCGCCACCTGCGCAACGAACCCACGCCGCCCTGGAATTCCC
TGCCGTCGGAGGCGCAATGA

Upstream 100 bases:

>100_bases
CCCTTCGATACGTTGGGCGTGGCGGTCATCGCGTTGTGCATTTATCACTGGGGCGCACGCAGCGGTTTGCGCAGCGACGA
GCTTGCGCTGGAGGAGGACG

Downstream 100 bases:

>100_bases
TGCGTTTGTCTGCTCGATTCAAGGCACAGCGGCGCAGCCGGGGGGCGGGTCTGCTGTGGTCGCTGGCGTTGCTGGCTGGT
AGCACACCGCTGCTTGCGGC

Product: peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MVSDARRSAFGLRRWSALVAYGLVLSGAVQAAPSVADYQRSLGLREQWITLTENVAWPAQWQDDGRFYYRKTVPGGFAFV
SADVATLQKQPAFDQARLAQGLSAATGKPYAPLRLPFEQFSFSTEGERSDGAIVFALDDAPWRCTLTTYRCAPDARLQPT
SRPRGFGVVRDPLVPADTTPRRSPDAKWEVLADGWNLVLRHLADGQVTRLSSDGRADDYFDPESVAWSPDSRQLAVYRVR
PGLARRITRVEAAPAGGGQPVVHTQLYPKPGDAVDVERPVLFALDGTRRDVDTALFDNPYSLSPLQWRSDGRSVAFEYVQ
RGFQRMRVIAVDAISGRARVAVGEDARTFVYADRSFRHDVDGRGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVV
RDVLRVDDAQRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHAEADHDVAIADDGLHYVDVYSRPDLPPVMELRAI
DGQLLHTVERGTIDRLQAAGWRAPETFVAKGRDGTSDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHS
GGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKDLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQST
LGALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDAHYAEASGVVNARKLQGDLLLIVGEQDSNVDPASTAQVVD
ALIRAGKEFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPPWNSLPSEAQ

Sequences:

>Translated_779_residues
MVSDARRSAFGLRRWSALVAYGLVLSGAVQAAPSVADYQRSLGLREQWITLTENVAWPAQWQDDGRFYYRKTVPGGFAFV
SADVATLQKQPAFDQARLAQGLSAATGKPYAPLRLPFEQFSFSTEGERSDGAIVFALDDAPWRCTLTTYRCAPDARLQPT
SRPRGFGVVRDPLVPADTTPRRSPDAKWEVLADGWNLVLRHLADGQVTRLSSDGRADDYFDPESVAWSPDSRQLAVYRVR
PGLARRITRVEAAPAGGGQPVVHTQLYPKPGDAVDVERPVLFALDGTRRDVDTALFDNPYSLSPLQWRSDGRSVAFEYVQ
RGFQRMRVIAVDAISGRARVAVGEDARTFVYADRSFRHDVDGRGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVV
RDVLRVDDAQRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHAEADHDVAIADDGLHYVDVYSRPDLPPVMELRAI
DGQLLHTVERGTIDRLQAAGWRAPETFVAKGRDGTSDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHS
GGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKDLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQST
LGALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDAHYAEASGVVNARKLQGDLLLIVGEQDSNVDPASTAQVVD
ALIRAGKEFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPPWNSLPSEAQ
>Mature_779_residues
MVSDARRSAFGLRRWSALVAYGLVLSGAVQAAPSVADYQRSLGLREQWITLTENVAWPAQWQDDGRFYYRKTVPGGFAFV
SADVATLQKQPAFDQARLAQGLSAATGKPYAPLRLPFEQFSFSTEGERSDGAIVFALDDAPWRCTLTTYRCAPDARLQPT
SRPRGFGVVRDPLVPADTTPRRSPDAKWEVLADGWNLVLRHLADGQVTRLSSDGRADDYFDPESVAWSPDSRQLAVYRVR
PGLARRITRVEAAPAGGGQPVVHTQLYPKPGDAVDVERPVLFALDGTRRDVDTALFDNPYSLSPLQWRSDGRSVAFEYVQ
RGFQRMRVIAVDAISGRARVAVGEDARTFVYADRSFRHDVDGRGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVV
RDVLRVDDAQRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHAEADHDVAIADDGLHYVDVYSRPDLPPVMELRAI
DGQLLHTVERGTIDRLQAAGWRAPETFVAKGRDGTSDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHS
GGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKDLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQST
LGALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDAHYAEASGVVNARKLQGDLLLIVGEQDSNVDPASTAQVVD
ALIRAGKEFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPPWNSLPSEAQ

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=418, Percent_Identity=28.4688995215311, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI37577089, Length=418, Percent_Identity=28.4688995215311, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI194394146, Length=367, Percent_Identity=27.5204359673025, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI37577091, Length=418, Percent_Identity=26.0765550239234, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI16933540, Length=546, Percent_Identity=22.1611721611722, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508019, Length=260, Percent_Identity=29.2307692307692, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17508017, Length=260, Percent_Identity=29.2307692307692, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17564632, Length=229, Percent_Identity=26.2008733624454, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17564634, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321817, Length=487, Percent_Identity=23.8193018480493, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324793, Length=614, Percent_Identity=20.0325732899023, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551969, Length=574, Percent_Identity=24.390243902439, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45550825, Length=574, Percent_Identity=24.390243902439, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45553511, Length=574, Percent_Identity=24.390243902439, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 86909; Mature: 86909

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDARRSAFGLRRWSALVAYGLVLSGAVQAAPSVADYQRSLGLREQWITLTENVAWPAQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHEEEEECCCCCCCC
WQDDGRFYYRKTVPGGFAFVSADVATLQKQPAFDQARLAQGLSAATGKPYAPLRLPFEQF
CCCCCEEEEEEECCCCEEEEEHHHHHHHCCCCCCHHHHHHCHHHCCCCCCCCEECCHHHC
SFSTEGERSDGAIVFALDDAPWRCTLTTYRCAPDARLQPTSRPRGFGVVRDPLVPADTTP
CCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCC
RRSPDAKWEVLADGWNLVLRHLADGQVTRLSSDGRADDYFDPESVAWSPDSRQLAVYRVR
CCCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCEEEEEEC
PGLARRITRVEAAPAGGGQPVVHTQLYPKPGDAVDVERPVLFALDGTRRDVDTALFDNPY
CCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCC
SLSPLQWRSDGRSVAFEYVQRGFQRMRVIAVDAISGRARVAVGEDARTFVYADRSFRHDV
CCCCCEECCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECCCCCCCC
DGRGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVVRDVLRVDDAQRRIWFTASGM
CCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCC
DAGKDPYDRQLYSVDFDGRRLTRLTHAEADHDVAIADDGLHYVDVYSRPDLPPVMELRAI
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHC
DGQLLHTVERGTIDRLQAAGWRAPETFVAKGRDGTSDIWGMVVRPRDYDPRKTYPVIENI
CHHHHHHHHHCCHHHHHHCCCCCCHHHEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHH
YAGPHDSFVPKTFWPFGYHSGGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKD
CCCCCCCCCCCCCCCCCCCCCCCCEECCEECCCCCEEEEEEECCCCCCCCCHHHHHHHHH
LGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPEFYKVGVAFAGC
CCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEEEH
YDNRMDKISWNEQWMGWPVDAHYAEASGVVNARKLQGDLLLIVGEQDSNVDPASTAQVVD
HCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCEEEEECCCCCCCCCHHHHHHHH
ALIRAGKEFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPPWNSLPSEAQ
HHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSDARRSAFGLRRWSALVAYGLVLSGAVQAAPSVADYQRSLGLREQWITLTENVAWPAQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHEEEEECCCCCCCC
WQDDGRFYYRKTVPGGFAFVSADVATLQKQPAFDQARLAQGLSAATGKPYAPLRLPFEQF
CCCCCEEEEEEECCCCEEEEEHHHHHHHCCCCCCHHHHHHCHHHCCCCCCCCEECCHHHC
SFSTEGERSDGAIVFALDDAPWRCTLTTYRCAPDARLQPTSRPRGFGVVRDPLVPADTTP
CCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCC
RRSPDAKWEVLADGWNLVLRHLADGQVTRLSSDGRADDYFDPESVAWSPDSRQLAVYRVR
CCCCCCCEEEEECCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCEEEEEEC
PGLARRITRVEAAPAGGGQPVVHTQLYPKPGDAVDVERPVLFALDGTRRDVDTALFDNPY
CCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCC
SLSPLQWRSDGRSVAFEYVQRGFQRMRVIAVDAISGRARVAVGEDARTFVYADRSFRHDV
CCCCCEECCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECCCCCCCC
DGRGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVVRDVLRVDDAQRRIWFTASGM
CCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCC
DAGKDPYDRQLYSVDFDGRRLTRLTHAEADHDVAIADDGLHYVDVYSRPDLPPVMELRAI
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHC
DGQLLHTVERGTIDRLQAAGWRAPETFVAKGRDGTSDIWGMVVRPRDYDPRKTYPVIENI
CHHHHHHHHHCCHHHHHHCCCCCCHHHEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHH
YAGPHDSFVPKTFWPFGYHSGGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKD
CCCCCCCCCCCCCCCCCCCCCCCCEECCEECCCCCEEEEEEECCCCCCCCCHHHHHHHHH
LGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPEFYKVGVAFAGC
CCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEEEH
YDNRMDKISWNEQWMGWPVDAHYAEASGVVNARKLQGDLLLIVGEQDSNVDPASTAQVVD
HCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCEEEEECCCCCCCCCHHHHHHHH
ALIRAGKEFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPPWNSLPSEAQ
HHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA