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The map label for this gene is ptpA [H]

Identifier: 21243265

GI number: 21243265

Start: 2973899

End: 2976244

Strand: Reverse

Name: ptpA [H]

Synonym: XAC2532

Alternate gene names: 21243265

Gene position: 2976244-2973899 (Counterclockwise)

Preceding gene: 21243266

Following gene: 21243264

Centisome position: 57.51

GC content: 66.28

Gene sequence:

>2346_bases
GTGAGGTCACAGATGCCACACATCCCCGCCATGCGCTTACGCACCATCCCTATCTGGTGCGTGTCTCTTGCACTGGCGCA
CATCGTGCCGGTGGCGGCGGCGCCACTCCCCGCTCCCACGCCGACGCAGTACACGCAGGCAATGGGCTTGTCCGATCACT
ATGCCTCGCTGGTGGACCGGCAGCCTACGGCGCCGGTGTGGGTGGATGCCGGGCATTTTCTCTATCGGCGTGGGGTGGCG
CGCAGCAAGCAGCTGCCGGCGATCGAATACCGCCTGGTGGAGGCGGCCAGTGGCCGCAACACACTGGCCTTCGATCACGC
GCGGCTGGCCGCAGCATTGACGCAGGCCGGTGCCAAGGCGGTCGACGCAGCGCGACTGCAGCTTGACGAGCCCACCCTGG
AACAGCAGCGCCTGAGCTTCCAGTTGGCGAAGCTCGGCTGGCAGTGCGATCTGCTGCGCTATCGCTGCGCGCATCTGCCC
GAACGCAACCTGCCGGCCGAATCGATGGACATGCGCCTGCCGCTCAAGCAGGGCGAACGCCAGGCCATGTTATCGCCGGA
TGGCCGCTGGCGTGCCTGGGTGGAGCAGGGCAATCTGGTCATCGCGCCGGTCGGCAGTCACGAGCGCAGCGTGCTCAGCC
ACGATGGCAGCACGGATGATTACTACGCGCTCGACAGCGTGGTGTGGTCCCCGGATTCGCAGCATCTGGCTGCGTATCGG
GTCAAGGCACCGCCGCCGCGCATGGTCTATTACATCGAGTCGGCGCCCGCCGATCAGGTGCAGCCGAAGTTGCATCAGCA
GGTCTATCCCAAGCCGGGCGATGTGCTGCCGATGATGCAGCCGGTCTTGTTCGACGTCGCCACGCACGCAGCCCATCCGG
TGGCGATGACCTTGCTGCCCAATGCCTTTGCCTTGAGCGAGATGGTCTGGTGGAAGGACAGCCGCGGCTTCACCTTCGAA
TACAACGCACGCGGTCACCAGCTGTACCGGGTGATCGAAGTCGACGCGCGGACGGCCGCCGCGCGCACGCTGATCGAAGA
GACATCGCCCACCTTCATCGAATACTCCGAGCTCAGTGGCGAGCATGAAAACGGCGGCAAGCACGCACGCCAGGACCTGG
ACGATGGCGCGCAGATCGTGTGGGCATCCGAGCGCGATGGCTGGGAGCACCTGTATCTGTACGACGGGCGCAGCGGCGAG
GTGATCCGCCAGATCACGCGGGGCGACTGGGTGGTGCGCAAGCTCGATCGCATCGACGAAGCGGCAGGGCAGGTGTACTT
TACCGCCTCGGGCATGCAGCCTGGCGAGGACCCGTACTATCGCCATGCCTATCGCATCGGCCTGGATGGCCGCGGGCTCA
CCGCCTTGACGCCGCTGGCTGCCGATCATGAGGTGCGCTATTCGCCGGATGGAAGGTGGCTACTGGATCTGTATTCGCGC
GTGGATCTGGGCCCGGTGCTGGAGCTGCGGCGCAGCGCAGATGGCAGCGTGGCACGCACGGTGGAGCGCACCGACCTGAG
CCGCCTGCTGGCCGCAGGATGGCAGGCGCCACTGCCGTTCCACACCACCGGGCGCGATGGCAGGACCGAGATCTGGGGCG
TCATCCATCGCCCGCAGCAGCTCGATCCGCAGCAGCGCTACCGGGTCGTCGAAGACATTTATGCCGGCCCGCAGGGCTCG
TTCGTCCCCAAGAGCTTTACCACCACCACACCGTCGCTCACCGGGATGGGGTTTGCGGTGGCGTCCATCGATGGCATGGG
CACCAACAACCGCTCGCGCGCCTTCCACGATGTGGCCTGGCGCAATCTCAAGGACGCCGGGTTGCCGGATCGTATCGCCT
GGCACAAGGCCGCCGCGGCGCAGTACCCGTGGTACGACATCGACGGCGGTGTCGGTGTGTACGGTACCTCGGCGGGCGGG
CAGAACGCGTTGGGGGCGCTGCTGTTTCATCCGGAGTTCTATGTGGCGGGTGTGGCCAATTCAGGGTGTCACGACAACCG
CATGGACAAGATCTGGTGGAACGAGCAGTGGATGGGCTGGCCGGTCGGCCCGTGGTACGCCGCATCGTCGAACGTGGAGA
ATGCCGCGCGCCTGCAGGGGCATCTGTTGCTGGTGACCGGCGACATGGACATGAATGTCGACCCGGCCAGCACCTTCCAG
GTGGCCGATCGCTTGATCAAGGCCGGCAAGGACTTCGATCTGCTGGTCGTGCCCGGTGGCGATCACGGTGCCGGTGGCGA
CTACGGCAGGCGCCGCCTGCTGGATTTCTTCCTGCGCTGGATGCAGCAAGCGCCAACGCCGGAGTGGAATCGCACCGCAG
CCGCGCCAGCCGCGCCGGCGCCGTGA

Upstream 100 bases:

>100_bases
GCGGCCTGCCGCACCGTCCTTGGTGTGTGTCTGTCGCTTCGGTTGCAGTCAGCGGCTCGGCCATCGTCCATCAACGCCAT
GCTGTCTTCTCAAACCTTCC

Downstream 100 bases:

>100_bases
TGCACGTGCGCTGCGGGTGGCATCCGTCGATTTGATCGCGCGAACCGGCGCATCCGAGCTCGATGCGCCGGTTCGCGCGC
GAATCCTTGTCGGCTTCATC

Product: peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MRSQMPHIPAMRLRTIPIWCVSLALAHIVPVAAAPLPAPTPTQYTQAMGLSDHYASLVDRQPTAPVWVDAGHFLYRRGVA
RSKQLPAIEYRLVEAASGRNTLAFDHARLAAALTQAGAKAVDAARLQLDEPTLEQQRLSFQLAKLGWQCDLLRYRCAHLP
ERNLPAESMDMRLPLKQGERQAMLSPDGRWRAWVEQGNLVIAPVGSHERSVLSHDGSTDDYYALDSVVWSPDSQHLAAYR
VKAPPPRMVYYIESAPADQVQPKLHQQVYPKPGDVLPMMQPVLFDVATHAAHPVAMTLLPNAFALSEMVWWKDSRGFTFE
YNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGRSGE
VIRQITRGDWVVRKLDRIDEAAGQVYFTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGRWLLDLYSR
VDLGPVLELRRSADGSVARTVERTDLSRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGS
FVPKSFTTTTPSLTGMGFAVASIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAQYPWYDIDGGVGVYGTSAGG
QNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQ
VADRLIKAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRTAAAPAAPAP

Sequences:

>Translated_781_residues
MRSQMPHIPAMRLRTIPIWCVSLALAHIVPVAAAPLPAPTPTQYTQAMGLSDHYASLVDRQPTAPVWVDAGHFLYRRGVA
RSKQLPAIEYRLVEAASGRNTLAFDHARLAAALTQAGAKAVDAARLQLDEPTLEQQRLSFQLAKLGWQCDLLRYRCAHLP
ERNLPAESMDMRLPLKQGERQAMLSPDGRWRAWVEQGNLVIAPVGSHERSVLSHDGSTDDYYALDSVVWSPDSQHLAAYR
VKAPPPRMVYYIESAPADQVQPKLHQQVYPKPGDVLPMMQPVLFDVATHAAHPVAMTLLPNAFALSEMVWWKDSRGFTFE
YNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGRSGE
VIRQITRGDWVVRKLDRIDEAAGQVYFTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGRWLLDLYSR
VDLGPVLELRRSADGSVARTVERTDLSRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGS
FVPKSFTTTTPSLTGMGFAVASIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAQYPWYDIDGGVGVYGTSAGG
QNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQ
VADRLIKAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRTAAAPAAPAP
>Mature_781_residues
MRSQMPHIPAMRLRTIPIWCVSLALAHIVPVAAAPLPAPTPTQYTQAMGLSDHYASLVDRQPTAPVWVDAGHFLYRRGVA
RSKQLPAIEYRLVEAASGRNTLAFDHARLAAALTQAGAKAVDAARLQLDEPTLEQQRLSFQLAKLGWQCDLLRYRCAHLP
ERNLPAESMDMRLPLKQGERQAMLSPDGRWRAWVEQGNLVIAPVGSHERSVLSHDGSTDDYYALDSVVWSPDSQHLAAYR
VKAPPPRMVYYIESAPADQVQPKLHQQVYPKPGDVLPMMQPVLFDVATHAAHPVAMTLLPNAFALSEMVWWKDSRGFTFE
YNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGRSGE
VIRQITRGDWVVRKLDRIDEAAGQVYFTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGRWLLDLYSR
VDLGPVLELRRSADGSVARTVERTDLSRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGS
FVPKSFTTTTPSLTGMGFAVASIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAQYPWYDIDGGVGVYGTSAGG
QNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQ
VADRLIKAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRTAAAPAAPAP

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=381, Percent_Identity=24.9343832020997, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI18450280, Length=415, Percent_Identity=24.8192771084337, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI37577089, Length=415, Percent_Identity=24.8192771084337, Blast_Score=89, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508019, Length=250, Percent_Identity=28.4, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508017, Length=250, Percent_Identity=28.4, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 86894; Mature: 86894

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSQMPHIPAMRLRTIPIWCVSLALAHIVPVAAAPLPAPTPTQYTQAMGLSDHYASLVDR
CCCCCCCCCCHHHEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHCC
QPTAPVWVDAGHFLYRRGVARSKQLPAIEYRLVEAASGRNTLAFDHARLAAALTQAGAKA
CCCCCEEECCCHHHHHHCCCCCCCCCHHHEEEEECCCCCCCEEEHHHHHHHHHHHHCHHH
VDAARLQLDEPTLEQQRLSFQLAKLGWQCDLLRYRCAHLPERNLPAESMDMRLPLKQGER
HHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCC
QAMLSPDGRWRAWVEQGNLVIAPVGSHERSVLSHDGSTDDYYALDSVVWSPDSQHLAAYR
CCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCCCEEEECCEEECCCCCCEEEEE
VKAPPPRMVYYIESAPADQVQPKLHQQVYPKPGDVLPMMQPVLFDVATHAAHPVAMTLLP
ECCCCCCEEEEECCCCCHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
NAFALSEMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSG
CHHHHHHHHEEECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEHHCCC
EHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGRSGEVIRQITRGDWVVRKLDRIDE
CCCCCCHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCHHHHHHHHHHHH
AAGQVYFTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGRWLLDLYSR
HCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCEEECCCCCCHHHHHHH
VDLGPVLELRRSADGSVARTVERTDLSRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQ
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCCCC
LDPQQRYRVVEDIYAGPQGSFVPKSFTTTTPSLTGMGFAVASIDGMGTNNRSRAFHDVAW
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
RNLKDAGLPDRIAWHKAAAAQYPWYDIDGGVGVYGTSAGGQNALGALLFHPEFYVAGVAN
HCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECCC
SGCHDNRMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQ
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHH
VADRLIKAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRTAAAPAAPA
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
P
C
>Mature Secondary Structure
MRSQMPHIPAMRLRTIPIWCVSLALAHIVPVAAAPLPAPTPTQYTQAMGLSDHYASLVDR
CCCCCCCCCCHHHEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHCC
QPTAPVWVDAGHFLYRRGVARSKQLPAIEYRLVEAASGRNTLAFDHARLAAALTQAGAKA
CCCCCEEECCCHHHHHHCCCCCCCCCHHHEEEEECCCCCCCEEEHHHHHHHHHHHHCHHH
VDAARLQLDEPTLEQQRLSFQLAKLGWQCDLLRYRCAHLPERNLPAESMDMRLPLKQGER
HHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCC
QAMLSPDGRWRAWVEQGNLVIAPVGSHERSVLSHDGSTDDYYALDSVVWSPDSQHLAAYR
CCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCCCEEEECCEEECCCCCCEEEEE
VKAPPPRMVYYIESAPADQVQPKLHQQVYPKPGDVLPMMQPVLFDVATHAAHPVAMTLLP
ECCCCCCEEEEECCCCCHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
NAFALSEMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSG
CHHHHHHHHEEECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEHHCCC
EHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGRSGEVIRQITRGDWVVRKLDRIDE
CCCCCCHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCHHHHHHHHHHHH
AAGQVYFTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGRWLLDLYSR
HCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCEEECCCCCCHHHHHHH
VDLGPVLELRRSADGSVARTVERTDLSRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQ
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCCCC
LDPQQRYRVVEDIYAGPQGSFVPKSFTTTTPSLTGMGFAVASIDGMGTNNRSRAFHDVAW
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
RNLKDAGLPDRIAWHKAAAAQYPWYDIDGGVGVYGTSAGGQNALGALLFHPEFYVAGVAN
HCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECCC
SGCHDNRMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQ
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHH
VADRLIKAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRTAAAPAAPA
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA