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The map label for this gene is mutL

Identifier: 21243139

GI number: 21243139

Start: 2800969

End: 2802846

Strand: Reverse

Name: mutL

Synonym: XAC2405

Alternate gene names: 21243139

Gene position: 2802846-2800969 (Counterclockwise)

Preceding gene: 21243140

Following gene: 21243138

Centisome position: 54.16

GC content: 66.51

Gene sequence:

>1878_bases
ATGGCGATCCGCCAGTTGCCCGAGATTTTGATCAACCAGATCGCTGCCGGCGAAGTTGTCGAGCGGCCCGCATCGGTGGT
CAAGGAACTGGTCGAAAATGCACTCGATGCCGGTGCCACGCGCGTGGATATCGAGCTCGAAGAGGGCGGCGTCCGGCTGA
TCCGTATCCGCGACAACGGTGGCGGTATCACCCCGGACGAACTGCCGCTGGCAGTCTCGCGGCATGCCACCAGCAAGATC
GCTTCGCTGGACGACCTGGAGACTGTCGCCACGCTTGGCTTTCGCGGCGAAGCCTTGCCGTCGATCGCCTCGGTCAGTCG
CTTTACCCTGACCTCGCGCCGCCACGACGCCGAACACGGCTCCGCATTGGAAATCGACGGCGGCCGCCTGGGCGAGGTGG
TGCCGCGCGCGCATGCGCCAGGCACCACGGTCGAAGTGCGCGAACTGTTCTTCAATGTGCCGGCACGGCGCAAGTTCCTG
CGTGCCGAACGCACCGAACTCGGCCACATCGAAGAGTGGTTGCGTTCGCTGGCGCTGGCGCGGCCGGATGTCGAATTGCG
CGTCTCGCACAACGGCAAGCCGTCGCGGCGTTACAAGCCGGGCGATCTGTATTCGGATGCGCGGCTGGGCGAAACGCTCG
GCGACGATTTTGCGCGCCAGGCCCTACGCGTGGACCACAGCGGCGCCGGTCTGCGCCTGCACGGCTGGGTTGCGCAACCG
CATTACTCGCGTGCCAGCACCGATCAGCAATACCTCTACGTCAACGGCCGTTCGGTCAGAGAACGCAGCGTGGCGCATGC
GGTGAAGATGGCCTACGGCGATGTGCTGTTCCATGGCCGCCAGCCGGCGTATGTGCTGTTTCTGGAGCTGGACCCGGCAC
GTGTGGACGTCAATGTGCATCCGGCCAAACACGAGGTGCGCTTCCGCGAAGCGCGGCTGATCCACGATTTCGTCTATCGC
ACCTTGCAGGATGCCTTGGCGCACACCCGCGCCGGCGCGACGCCGAACAGCATCGGCGGCGACGGCACCGGCTACACGGC
CGCCACGTCTGGCGGAATGGGCGGCATCGCCAGTGGCGGCGTTCCAGGTAATGGCGGCGCATCCATTGGCAGCGGTGGCG
CTTACAGCTACGCCAGCTGGACGCCTTCGCAAACGCCGCTGGGGCTGCGTGTGGACGAGGCGCGCGCCGCCTACAGCGCG
CTGTATGCACCACCGCCGAGCAGCGCGCAGCAATCGGCAGGCATGCCGAACATGGCCGGCACCGGATTGCCGGCAACTGC
GCAAGACAGCGGTGTGCCGCCGCTCGGTTATGCCATCGCGCAGTTGCACGGCATCTACATCCTGGCCGAGAACGCCGAAG
GCTTGATCGTGGTCGACATGCACGCGGCGCACGAGCGCATCGGCTATGAGCGGCTCAAACATGCGCATGACAGCATCGGC
CTGCACGCGCAACCGCTGCTGGTGCCGATGACGCTGGCAGTAGGCGAGCGCGAAGCCGACACCGCCGAGCGCGAAGCGGA
GACGTTGGCCACGCTGGGCTTCGAGATCACCCGCGCCGGCCCGCAGTCGCTGCACGTGCGCAGCATTCCCGCGCTGCTGG
CCAATGCCGAACCGGAGGCGCTGCTGCGCGATGTGCTGAGCGATCTGCGCGAGCATGGTCAAAGCCGCCGCATCGCCAGC
GCACGCGACGAGCTGCTCTCCACCATGGCGTGCCACGGCGCGGTGCGCGCCAACCGCCGCCTCACCGTGCCCGAAATGAA
CGCGTTGCTGCGCGATATGGAAGCCACCGAACGCTCGGGCCAATGCAACCATGGCCGACCGACCTGGGCGCGGTTTACGC
TGAGCGATATCGATCGTTGGTTTTTGAGGGGGCGTTGA

Upstream 100 bases:

>100_bases
CGGCGTCTGCGCGCCGCCGGATTGCCGTGCCGATGTCCGTCTTGTCTGTCACACCGCCGATCTACCGCGTTTCGCGCGTG
CCGCACTGGAGCGTGCGCTG

Downstream 100 bases:

>100_bases
TGGCAGTGCACAGGGGGAAGGGCTGGCTGCTCGGCATGTTAGTGGCGGCAATATTGGTCGGGTGCGGGCGCGATGCACCA
CCGCCGGCTGCGCCGGTCGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGITPDELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRERSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAHTRAGATPNSIGGDGTGYTAATSGGMGGIASGGVPGNGGASIGSGGAYSYASWTPSQTPLGLRVDEARAAYSA
LYAPPPSSAQQSAGMPNMAGTGLPATAQDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKHAHDSIG
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLSDLREHGQSRRIAS
ARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR

Sequences:

>Translated_625_residues
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGITPDELPLAVSRHATSKI
ASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFL
RAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
HYSRASTDQQYLYVNGRSVRERSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYR
TLQDALAHTRAGATPNSIGGDGTGYTAATSGGMGGIASGGVPGNGGASIGSGGAYSYASWTPSQTPLGLRVDEARAAYSA
LYAPPPSSAQQSAGMPNMAGTGLPATAQDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKHAHDSIG
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLSDLREHGQSRRIAS
ARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR
>Mature_624_residues
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNGGGITPDELPLAVSRHATSKIA
SLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHGSALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLR
AERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQPH
YSRASTDQQYLYVNGRSVRERSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRT
LQDALAHTRAGATPNSIGGDGTGYTAATSGGMGGIASGGVPGNGGASIGSGGAYSYASWTPSQTPLGLRVDEARAAYSAL
YAPPPSSAQQSAGMPNMAGTGLPATAQDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKHAHDSIGL
HAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEALLRDVLSDLREHGQSRRIASA
RDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLSDIDRWFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=33.6363636363636, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI4505911, Length=404, Percent_Identity=29.2079207920792, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=30.3951367781155, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=29.2397660818713, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=29.2397660818713, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458896, Length=397, Percent_Identity=29.9748110831234, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=26.510067114094, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI91992162, Length=330, Percent_Identity=26.3636363636364, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI91992160, Length=330, Percent_Identity=26.3636363636364, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790612, Length=565, Percent_Identity=42.1238938053097, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=34.5911949685535, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=341, Percent_Identity=28.7390029325513, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=315, Percent_Identity=33.968253968254, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=28.808864265928, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=716, Percent_Identity=21.0893854748603, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=374, Percent_Identity=24.5989304812834, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136968, Length=338, Percent_Identity=33.7278106508876, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=369, Percent_Identity=28.7262872628726, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_XANAC (Q8PJX2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642721.1
- ProteinModelPortal:   Q8PJX2
- SMR:   Q8PJX2
- GeneID:   1156476
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2405
- NMPDR:   fig|190486.1.peg.2365
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- ProtClustDB:   PRK00095
- BioCyc:   XAXO190486:XAC2405-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67622; Mature: 67491

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
GGITPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
HYSRASTDQQYLYVNGRSVRERSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAHTRAGATPNSIGGDGTGYTAATSGGMGGIASGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
VPGNGGASIGSGGAYSYASWTPSQTPLGLRVDEARAAYSALYAPPPSSAQQSAGMPNMAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
TGLPATAQDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKHAHDSIG
CCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCC
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHCCCCHHH
LLRDVLSDLREHGQSRRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSG
HHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
QCNHGRPTWARFTLSDIDRWFLRGR
CCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
AIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIELEEGGVRLIRIRDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
GGITPDELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLTSRRHDAEHG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SALEIDGGRLGEVVPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGDDFARQALRVDHSGAGLRLHGWVAQP
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
HYSRASTDQQYLYVNGRSVRERSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVH
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEC
PAKHEVRFREARLIHDFVYRTLQDALAHTRAGATPNSIGGDGTGYTAATSGGMGGIASGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
VPGNGGASIGSGGAYSYASWTPSQTPLGLRVDEARAAYSALYAPPPSSAQQSAGMPNMAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
TGLPATAQDSGVPPLGYAIAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKHAHDSIG
CCCCCCCCCCCCCHHHHHHHHHCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCC
LHAQPLLVPMTLAVGEREADTAEREAETLATLGFEITRAGPQSLHVRSIPALLANAEPEA
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHCCCCHHH
LLRDVLSDLREHGQSRRIASARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSG
HHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
QCNHGRPTWARFTLSDIDRWFLRGR
CCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217