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The map label for this gene is pyrC [H]

Identifier: 21243094

GI number: 21243094

Start: 2754302

End: 2755651

Strand: Direct

Name: pyrC [H]

Synonym: XAC2360

Alternate gene names: 21243094

Gene position: 2754302-2755651 (Clockwise)

Preceding gene: 21243093

Following gene: 21243095

Centisome position: 53.22

GC content: 64.22

Gene sequence:

>1350_bases
ATGAGCCGAACCGTCATCGTCAATGCCCGCCTGGTCAATGAAGGCAAGGAGTTCGACGCCGATCTCCTGATCGAGGGCGG
CCGCATCGCCAAGATCGACAGCAAGATCGTCCCTGCCCCTGGCGATACCGTGGTGGACGCCGCCGGACGCTGGGTGCTGC
CAGGCATGATCGACGACCAGGTGCACTTCCGCGAGCCCGGCCTGACCCACAAGGGCGACATCGCGACCGAATCCGGCGCC
GCTGTCGCTGGTGGCCTGACCAGCTTCATGGACATGCCCAACACCAATCCGCCGACCCTGGATGCCGCCGCACTGCAGGC
CAAGTACGACGCCGCCGCCGGGCGCGCCTGGGCCAACTACGGCTTCTACATGGGCGCCAGCAACGACAACCTGGCCCACA
TCCAATCGCTGGACCCCAAGACTGCACCAGGCATCAAGGTGTTCATGGGCGCCTCCACCGGCAACATGCTGGTCGATAAC
CCCGAAACGCTGGACGCCATCTTCCGCGACGCGCCCACGCCGATCATCACTCACTGCGAAGACACCCCGACCATTGATGC
GACGATGGCGCAGTACAAGGAAAAATACGGCGATGCGCTGACACCGGAGATGCACCCGGACATCCGTTCGCGTCAAGCCT
GCCTGAAGTCGTCGCAGCTGGCGGTGTCGCTGGCGCGCAAGCACAATACCCGCCTGCACGTATTGCACATCTCCACTGCC
GACGAGCTGTCGCTGTTCGAAGCCGGCCCGCTGGTCGATGCCGACGGCAAGCTGCGCAAGCGCATTACCGCCGAGACCTG
CATCCACTTCTTGCGCTTCGATCGCAGCGATTACGCGCGACTGGGCAACCTGATCAAGTGCAACCCCGCGATCAAGGACG
CCGAAGATCGTCTGGCGCTCATCGATGCGCTGGCCGAAGACGTCATCGACGTGCTCGCCACCGACCACGCCCCGCACACC
TGGGAAGAAAAGCAAAAGCCCTATGCGCAGGCGCCCTCGGGCCTGCCGCTGGTGCAGTACGCGCTGGTCGCGGCACTGGA
GCTGGTGCACGAAGGCAAGTTGCCGATCACCCGTATCGTGCAGAAGTTCGCGCATGCGCCGGCGCAGTTGTTCGATGTGG
AAGAACGCGGCTTCCTGCGCGAAGGCTATTTCGCCGACCTGGTGATGATCGACAACACGCCGTTCACCGTGAAGCGCGAG
CAGGTGCTGTCCAAGTGCGGCTGGTCGCCGTTCGAAGGCACCACCTTCCGTTCGCGCATTGCCGCAACCTGGGTCAACGG
CCAGCAGGTTTGGGATGGCGAACAGCTGGTGGGCAGCGCTGCCGGCCAGCGCCTGACCTTCGACCGCTGA

Upstream 100 bases:

>100_bases
GCCGCTGTCATCCCTTCCATCCGGGCGGATTCGATCCGGTGCCCGATGCGCCCACCTCGCCCTCCCCGTCTTCTTCCTGC
AGCTGCAAAGGACCCCATCC

Downstream 100 bases:

>100_bases
TGCGCGCAGTCCTGTTTGGCGCCTGGTTGATCCTGGCGCCAGTCGCGCTGGTTGCAGGACGCGCCGATGCGCAGAGTGCG
GCCGTCGCAACTGATGTCGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKIVPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMAQYKEKYGDALTPEMHPDIRSRQACLKSSQLAVSLARKHNTRLHVLHISTA
DELSLFEAGPLVDADGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDAEDRLALIDALAEDVIDVLATDHAPHT
WEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVKRE
QVLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR

Sequences:

>Translated_449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKIVPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMAQYKEKYGDALTPEMHPDIRSRQACLKSSQLAVSLARKHNTRLHVLHISTA
DELSLFEAGPLVDADGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDAEDRLALIDALAEDVIDVLATDHAPHT
WEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVKRE
QVLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR
>Mature_448_residues
SRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKIVPAPGDTVVDAAGRWVLPGMIDDQVHFREPGLTHKGDIATESGAA
VAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNP
ETLDAIFRDAPTPIITHCEDTPTIDATMAQYKEKYGDALTPEMHPDIRSRQACLKSSQLAVSLARKHNTRLHVLHISTAD
ELSLFEAGPLVDADGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDAEDRLALIDALAEDVIDVLATDHAPHTW
EEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIVQKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVKREQ
VLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=397, Percent_Identity=28.9672544080605, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI19923821, Length=417, Percent_Identity=22.3021582733813, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=23.695652173913, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4503051, Length=463, Percent_Identity=21.3822894168467, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI62422571, Length=432, Percent_Identity=21.5277777777778, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786722, Length=451, Percent_Identity=27.2727272727273, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=24.5652173913043, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=387, Percent_Identity=29.9741602067183, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71989490, Length=458, Percent_Identity=25.3275109170306, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=418, Percent_Identity=27.0334928229665, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=30.6532663316583, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18859883, Length=443, Percent_Identity=26.1851015801354, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI221377917, Length=466, Percent_Identity=25.5364806866953, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49111; Mature: 48980

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKIVPAPGDTVVDAAGRWVLPGMIDDQ
CCCEEEEEEEEECCCCCCCCEEEEECCEEEEECCEECCCCCCHHHHCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMAQYKEKYGDALTPEMHPDIRSRQACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELSLFEAGPLVDADGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDAEDRLAL
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHHHHH
IDALAEDVIDVLATDHAPHTWEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIV
HHHHHHHHHHHHHCCCCCCCHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVKREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHEECHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGQQVWDGEQLVGSAAGQRLTFDR
EEEEECCCEECCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRTVIVNARLVNEGKEFDADLLIEGGRIAKIDSKIVPAPGDTVVDAAGRWVLPGMIDDQ
CCEEEEEEEEECCCCCCCCEEEEECCEEEEECCEECCCCCCHHHHCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLDAAALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMAQYKEKYGDALTPEMHPDIRSRQACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELSLFEAGPLVDADGKLRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDAEDRLAL
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHHHHH
IDALAEDVIDVLATDHAPHTWEEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRIV
HHHHHHHHHHHHHCCCCCCCHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEERGFLREGYFADLVMIDNTPFTVKREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHEECHHCCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGQQVWDGEQLVGSAAGQRLTFDR
EEEEECCCEECCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA