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The map label for this gene is argB [H]

Identifier: 21243082

GI number: 21243082

Start: 2743102

End: 2744445

Strand: Reverse

Name: argB [H]

Synonym: XAC2348

Alternate gene names: 21243082

Gene position: 2744445-2743102 (Counterclockwise)

Preceding gene: 21243083

Following gene: 21243081

Centisome position: 53.03

GC content: 62.43

Gene sequence:

>1344_bases
ATGTCCTCTTCCGCACAGCCCCACAAACAGACCCGCCAGACCATCGTGCGCCTGCTCTCGAGCATGGCCAGCGCGAAGGA
AATCAGCCAGTACCTCAAGCGGTTTTCGCAGCTCGATGCCAAGCGCTTTGCGGTGGTCAAGGTGGGCGGCGCGGTGTTGC
GCGACGATCTGGACGCGCTGACCTCGTCGCTGTCGTTCCTGCAGGAAGTGGGGTTGACCCCGATCGTGCTGCATGGCGCC
GGCCCGCAGCTGGATGCAGAGCTGTCGGCAGCCGGCATCGAAAAGCACACCATCAACGGACTGCGCGTCACCTCGCCGGA
AGCGTTGGCGATCGTGCGCAAGGTGTTCCAGGCCTCCAACCTGAAACTGGTGGAAGCGCTCCAGCAGAACGGCGCGCGTG
CGACCTCGATCACCGGTGGCGTGTTCGAGGCCGAGTATCTGGATCGCGACATCTACGGCCTGGTCGGTGAGGTCAAGGCG
GTGAATCTGGCGCCGATCGAAGCCAGTCTGCAGGCCGGCTCCATCCCGGTGATCACCAGCCTGGGCGAAACGCCCAGCGG
GCAGATCCTCAACGTCAATGCGGATTTTGCCGCCAACGAGTTGGTGCAGGAGCTGCAGCCGTACAAGATCATTTTCCTTA
CCGGCACCGGCGGCCTGCTGGATGCCGATGGCAAGTTGATCGACTCGATCAACCTGTCTACCGAGTTCGATCACCTGATG
CAGCAGCCGTGGATCAATGGCGGCATGCGGGTCAAGATCGAGCAGATCAAGGACTTGCTCGATCGTCTGCCGCTGGAGTC
GTCGGTGTCGATCACCCGGCCGTCGGACCTGGCCAAGGAGCTGTTCACCCACAAGGGCTCGGGCACGCTGGTGCGGCGCG
GCGAGCGCGTGCTGCGCGCGACCTCCTGGGACGAACTGGATCTGCCTCGCCTGAAGTCGCTGATCGAATCCAGCTTCGGC
CGCACGCTGGTGCCGGACTATTTCGACACCACCACGTTGCTGCGCGCGTATGTCAGCGAAAACTACCGTGCGGCGGTGAT
CCTGACCGACGAGGGCCAGTTCGGTGCGGGCAGGTTGACCTATCTGGACAAGTTCGCCGTGCTCGACGACGCGCAGGGCG
AAGGTCTTGGCCGCGCGGTGTGGAATGTGATGCGCGAAGAGACCCCGCAGCTGTTCTGGCGCTCGCGCCATAACAACCAG
GTCAATATCTTTTACTACGCCGAATCCGACGGTTGCATCAAGCAGGAGAAGTGGAAGGTGTTCTGGTACGGGCTGGAAAA
TTTCGAGCAGATCCAGCATTGCGTTGCGCACTGTGCGACGCGTCAGCCGACTTTGCTGGGCTGA

Upstream 100 bases:

>100_bases
CGCAATTGCAGCGTTACGCCGAATCGGTCCATCGCATCATCAACGGTTCCCACTGAACCGACACGCGCCTGGCGCCCCCT
TTCCTCTTTCGAACACGGCA

Downstream 100 bases:

>100_bases
GTGCGATGAGCGCCGTCGGCTTGCCGCCCCTTTGGCGCGAACAGCCCAGCCTGCGTGGACGGCACGCGAGCCTGGAGCCG
CTGCAGGCAGCGCATGCCGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSSSAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGA
GPQLDAELSAAGIEKHTINGLRVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDIYGLVGEVKA
VNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLM
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFG
RTLVPDYFDTTTLLRAYVSENYRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQ
VNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG

Sequences:

>Translated_447_residues
MSSSAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGA
GPQLDAELSAAGIEKHTINGLRVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDIYGLVGEVKA
VNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLM
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFG
RTLVPDYFDTTTLLRAYVSENYRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQ
VNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG
>Mature_446_residues
SSSAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAG
PQLDAELSAAGIEKHTINGLRVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDIYGLVGEVKAV
NLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQ
QPWINGGMRVKIEQIKDLLDRLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGR
TLVPDYFDTTTLLRAYVSENYRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQV
NIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the acetylglutamate kinase family [H]

Homologues:

Organism=Homo sapiens, GI23308587, Length=422, Percent_Identity=34.8341232227488, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1789181, Length=284, Percent_Identity=22.1830985915493, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693208, Length=241, Percent_Identity=27.3858921161826, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320913, Length=452, Percent_Identity=41.3716814159292, Blast_Score=342, Evalue=1e-94,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011242
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR006855 [H]

Pfam domain/function: PF00696 AA_kinase; PF04768 DUF619 [H]

EC number: =2.7.2.8 [H]

Molecular weight: Translated: 49380; Mature: 49249

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCHHHHHHHHHH
TSSLSFLQEVGLTPIVLHGAGPQLDAELSAAGIEKHTINGLRVTSPEALAIVRKVFQASN
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCHHHCCCCEEECCHHHHHHHHHHHHCCC
LKLVEALQQNGARATSITGGVFEAEYLDRDIYGLVGEVKAVNLAPIEASLQAGSIPVITS
HHHHHHHHHCCCEEEEECCCCEEHHHHCCHHHHHHHCCEEEEECCCHHCCCCCCCCEEEE
LGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLM
CCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHH
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRA
HCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHC
TSWDELDLPRLKSLIESSFGRTLVPDYFDTTTLLRAYVSENYRAAVILTDEGQFGAGRLT
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
YLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKV
HHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
FWYGLENFEQIQHCVAHCATRQPTLLG
EEEEHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSSAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCHHHHHHHHHH
TSSLSFLQEVGLTPIVLHGAGPQLDAELSAAGIEKHTINGLRVTSPEALAIVRKVFQASN
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCHHHCCCCEEECCHHHHHHHHHHHHCCC
LKLVEALQQNGARATSITGGVFEAEYLDRDIYGLVGEVKAVNLAPIEASLQAGSIPVITS
HHHHHHHHHCCCEEEEECCCCEEHHHHCCHHHHHHHCCEEEEECCCHHCCCCCCCCEEEE
LGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLM
CCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHH
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRA
HCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHC
TSWDELDLPRLKSLIESSFGRTLVPDYFDTTTLLRAYVSENYRAAVILTDEGQFGAGRLT
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
YLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKV
HHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
FWYGLENFEQIQHCVAHCATRQPTLLG
EEEEHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]