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The map label for this gene is ybdL [H]

Identifier: 21243057

GI number: 21243057

Start: 2716348

End: 2717496

Strand: Reverse

Name: ybdL [H]

Synonym: XAC2322

Alternate gene names: 21243057

Gene position: 2717496-2716348 (Counterclockwise)

Preceding gene: 21243069

Following gene: 21243056

Centisome position: 52.51

GC content: 65.27

Gene sequence:

>1149_bases
ATGCCCCTTACGACCAAGCTGCCCAAGGTGGGCACCACCATCTTCACCGTCATGTCGCAGCTGGCGGCCGAGCACGGCGC
GGTCAATCTGGGCCAGGGCTTTCCCGATTTCGCGGTGCCGCAGCGGCTGGTCGACGAACTGAGCAAGGCGATGGCGGCCG
GCCACAACCAGTATCCACCGATGACCGGCGTGGCCACATTACGCCAGGCCATCGCCGGCAAGGCGCAGCGCTGCTATGGC
GCGCAGGTCGATGCCGACACCGAGATCACCGTCACCAGCGGTGCCACCGAGGCCATCTTCAACGCCATCCACGCGGTGGT
GCGCGCCGGCGAAGAGGTCATCGTGCTGGACCCGGCCTACGACTGCTACGAGCCGGCGATCGATCTGGCCGGCGCGCGGG
CGGTTCACGTAGCGCTGCACCCGCAGACCTTTGCGGTGGACTGGGATGCGCTGCGCGCCGCGATCACGCCCAAGACGCGC
CTGTTGATGATCAACTCGCCGCACAACCCGTCCGGCGCGATGCTGTCGGCCGAGGACATGCAGACGCTGACCGAACTGCT
GCGCGGCACCGAGATCTTTTTGCTGTCCGATGAGGTCTACGAACACATCGTGTTCGATGGCCGCCGGCACGAGTCGGTGC
TGCGCTGGCCGGCACTGCGCGAGCGCGCATTCGTGATTTCCAGCTTCGGCAAAACCTACCACTGCACGGGCTGGAAGATC
GGCTACGCCATCGCGCCGCCGGCGCTAACGGCCGAATTCCGCAAGGTGCACCAGTACAACACCTTCACCAGCTTCGGTCC
GGCCCAGCACGCCTTCGCTGCGATGATCCGCGACGAACCCGAACACGACGAGCAACTGGGCGCGTTCTATCAAGCCAAGC
GCGACCGGTTCCGCGAACAATTGCTGGCCACGCGCTTGAAGCCGTTGCCTGTGCCCGGCGGCTACTTCCAGTTGGTGGAT
TACTCGGCCATCAGCGATCTGCCCGATACCGAATTCGTGAAGTGGCTAACGATCGAGAACGGCGTGGCCGCGATCCCGTT
GTCGCCGTTCTACGAGAACGCGCCTGCAGGGCAGCGCCTGGCACGGCTGTGCTTTGCCAAGAACGATGCGACGCTGGATG
CGGCGATCGAGCGCCTGCGTAGGCTCTGA

Upstream 100 bases:

>100_bases
GCGGTGTGTCAGGGAACGCTGTCTTGCAGCGTCCGGGCGCAACCTGCTGGCGGCTTTGCGTACACTCGCGGTCCCCCCGT
TTCTTGTCCGGACAGGCACC

Downstream 100 bases:

>100_bases
CGAGCCGGGAATCGGGATTCGGGAATCGTAAGAGCGATCGGCCGCTTTTTGATCTGAATTCGCACTGGCTCGATGACATA
ACGCCCTCATTAAACCGCTG

Product: aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPLTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDELSKAMAAGHNQYPPMTGVATLRQAIAGKAQRCYG
AQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALHPQTFAVDWDALRAAITPKTR
LLMINSPHNPSGAMLSAEDMQTLTELLRGTEIFLLSDEVYEHIVFDGRRHESVLRWPALRERAFVISSFGKTYHCTGWKI
GYAIAPPALTAEFRKVHQYNTFTSFGPAQHAFAAMIRDEPEHDEQLGAFYQAKRDRFREQLLATRLKPLPVPGGYFQLVD
YSAISDLPDTEFVKWLTIENGVAAIPLSPFYENAPAGQRLARLCFAKNDATLDAAIERLRRL

Sequences:

>Translated_382_residues
MPLTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDELSKAMAAGHNQYPPMTGVATLRQAIAGKAQRCYG
AQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALHPQTFAVDWDALRAAITPKTR
LLMINSPHNPSGAMLSAEDMQTLTELLRGTEIFLLSDEVYEHIVFDGRRHESVLRWPALRERAFVISSFGKTYHCTGWKI
GYAIAPPALTAEFRKVHQYNTFTSFGPAQHAFAAMIRDEPEHDEQLGAFYQAKRDRFREQLLATRLKPLPVPGGYFQLVD
YSAISDLPDTEFVKWLTIENGVAAIPLSPFYENAPAGQRLARLCFAKNDATLDAAIERLRRL
>Mature_381_residues
PLTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDELSKAMAAGHNQYPPMTGVATLRQAIAGKAQRCYGA
QVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALHPQTFAVDWDALRAAITPKTRL
LMINSPHNPSGAMLSAEDMQTLTELLRGTEIFLLSDEVYEHIVFDGRRHESVLRWPALRERAFVISSFGKTYHCTGWKIG
YAIAPPALTAEFRKVHQYNTFTSFGPAQHAFAAMIRDEPEHDEQLGAFYQAKRDRFREQLLATRLKPLPVPGGYFQLVDY
SAISDLPDTEFVKWLTIENGVAAIPLSPFYENAPAGQRLARLCFAKNDATLDAAIERLRRL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=404, Percent_Identity=35.1485148514851, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI56713256, Length=404, Percent_Identity=35.1485148514851, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI95147551, Length=396, Percent_Identity=34.0909090909091, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI169881279, Length=396, Percent_Identity=34.0909090909091, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI169881281, Length=394, Percent_Identity=30.4568527918782, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4507369, Length=330, Percent_Identity=23.9393939393939, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786816, Length=378, Percent_Identity=55.8201058201058, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI1788722, Length=301, Percent_Identity=25.2491694352159, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788627, Length=220, Percent_Identity=28.1818181818182, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787710, Length=284, Percent_Identity=30.2816901408451, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=404, Percent_Identity=34.9009900990099, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71994476, Length=404, Percent_Identity=34.9009900990099, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17567369, Length=399, Percent_Identity=31.5789473684211, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17567663, Length=361, Percent_Identity=20.4986149584488, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=389, Percent_Identity=31.8766066838046, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28573069, Length=393, Percent_Identity=33.0788804071247, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24646114, Length=393, Percent_Identity=33.0788804071247, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28573067, Length=393, Percent_Identity=33.0788804071247, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28573065, Length=393, Percent_Identity=33.0788804071247, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI18859735, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 42122; Mature: 41990

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDELSKAMAAGHNQYPP
CCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
MTGVATLRQAIAGKAQRCYGAQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAY
CHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCH
DCYEPAIDLAGARAVHVALHPQTFAVDWDALRAAITPKTRLLMINSPHNPSGAMLSAEDM
HHHHHHHHHCCCEEEEEEECCCEEEECHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHH
QTLTELLRGTEIFLLSDEVYEHIVFDGRRHESVLRWPALRERAFVISSFGKTYHCTGWKI
HHHHHHHCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPPALTAEFRKVHQYNTFTSFGPAQHAFAAMIRDEPEHDEQLGAFYQAKRDRFREQ
CEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLATRLKPLPVPGGYFQLVDYSAISDLPDTEFVKWLTIENGVAAIPLSPFYENAPAGQRL
HHHHHCCCCCCCCCCEEEEEHHHHCCCCCCHHEEEEEECCCEEEEECCCCCCCCCHHHHH
ARLCFAKNDATLDAAIERLRRL
HHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PLTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDELSKAMAAGHNQYPP
CCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
MTGVATLRQAIAGKAQRCYGAQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAY
CHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCH
DCYEPAIDLAGARAVHVALHPQTFAVDWDALRAAITPKTRLLMINSPHNPSGAMLSAEDM
HHHHHHHHHCCCEEEEEEECCCEEEECHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHH
QTLTELLRGTEIFLLSDEVYEHIVFDGRRHESVLRWPALRERAFVISSFGKTYHCTGWKI
HHHHHHHCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPPALTAEFRKVHQYNTFTSFGPAQHAFAAMIRDEPEHDEQLGAFYQAKRDRFREQ
CEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLATRLKPLPVPGGYFQLVDYSAISDLPDTEFVKWLTIENGVAAIPLSPFYENAPAGQRL
HHHHHCCCCCCCCCCEEEEEHHHHCCCCCCHHEEEEEECCCEEEEECCCCCCCCCHHHHH
ARLCFAKNDATLDAAIERLRRL
HHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]