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The map label for this gene is hlyD [H]

Identifier: 21242936

GI number: 21242936

Start: 2583716

End: 2585191

Strand: Reverse

Name: hlyD [H]

Synonym: XAC2201

Alternate gene names: 21242936

Gene position: 2585191-2583716 (Counterclockwise)

Preceding gene: 21242937

Following gene: 21242935

Centisome position: 49.95

GC content: 70.46

Gene sequence:

>1476_bases
ATGAACGCTTCCACGCCCAGAGGGCCCGCCGCGGCCGAATCGCGGCACCCCGCGCACCTGCTCCTGCAGCGCTACGCGGA
CATCTTCCGCGCGGCCTGGGCGCAACGCGCGGCGCTGGCCGGTCCGCCGTGGCTCGCCGACGAACGCGCCTTCTTGCCGG
CCGCGCTAAGCCTGCAGGAAACCCCCGTCCATCCCGCGCCGCGGCGCCTCGCCTGGCTGGTCATGGCGCTCTTCGCGATC
GCGCTGGTATGGTCCATCTTCGGCAGGATCGACATCGTCGCAGTGGCGCCGGGCCGCATCATCGTCAGCGACCGCACCAA
GCTCGTCCAGCCTTTGGAAAACAGCGTCGTGCGGCGCGTGCTCGTGCGAGAAGGCGATCACGTCGAGGCGGGCCAGCCGC
TGCTCGAACTCGATCCCACCGCCGCGCACGCCGATCGCACCAGCTTCGGCGAGGCGCATCGTGCGGCCGAATCGGAGTCG
CTTCGCGTGCGGGCGCTGCAGGCGACACTGGCAGGTGAGGCGGGCCCCGGCACGAAACTGCCCCGCTGGTCCCCGCAAGA
CATCCCCGCCGCGTGGAGTGCCCGCGAACGTACGGACGCGCAAGCGCAGTTGCTGGCCGAATGGAGCGACATCACCGCGC
GCACGGCCCGCCTGGACGCCGAGCGCCAACGCCGGGAGGCCGAGATCGCCACGGTGCGCGCCATGGTCGCCAAGCTCGAA
ACGACGCTGCCCGTGGTGCGCCAGCGCGAAGCGGACTTCCAGACCCTCGCCGCGCAAGGCTTCATGTCCGGCCACGCCAC
CCAGGACCGCATGCGCGAGCGCGTGGAAATGGAACGCGACCTGGCCACCCAGCAGGCCCGCCTGCAGGAAGCCCTCGCCA
CGCTGGCCGAGGCGCGGCAGGCGCGCATGTCCTATCTCGCTGAAACCCGCCGCGCCTTGAGCGAGCGGCAAGCGCAGGCG
GACCTCAAACGCGAGCAGAACGCGCAAGAACTCTCCAAGGCGGAGCGGCGCGAGCGCTTGGCGACCCTCGCCGCGCCCGT
GAGCGGCACCGTGCAGCAGTTGGCCGCACACACCGAGGGCGGTGTCGTGACGGAGGCGCAGGTGCTCATGGTCATCGTGC
CCGACGGCGCCCAGGTGAGCGCCGAGGTCACGCTGGAGAACAAGGACATCGGCTTCGTCGAGCCGGGGCAGGACGTCACG
ATCAAGCTGGAGACCTTCCCGTTCACCCGGTATGGGACGGTGCCCGCCCAGGTGGAGACCGTCACGCGCGATGCGGTCAA
CGACGAGAAGCGCGGGGCGATTTTCCCGGCGTTGTTGCGGCTGGGTACGGGCCACATCGCCGTGGACGGCAAGGACATCC
GCCTTGCCCCCGGCATGAACCTGACAGCCGAGATCAAGACCGGCCAGCGCCGGGTGATCGACTACCTGTTGAGTCCCATC
CAGAAGGCGGGCAGCGAGAGCCTGCGCGAGCGCTGA

Upstream 100 bases:

>100_bases
GCCCGCAGGGGCTCTACGCCCACCTGTGGCGCATGCAGGACGGGGGCGGCGGCACGGTTCCAATGACTCGCACTGGTCCG
CGCACCGAGGAGGTGGTGGC

Downstream 100 bases:

>100_bases
GGCAATGGTCCGGCAGGACACACGAGCACACGAGTTTTAAACACCAAGGAATGGAAGAAGAGCATGAAGGACAGCAACGC
ACAAACCACCCTCGCTTCCG

Product: hemolysin secretion protein D

Products: NA

Alternate protein names: APX-IIID; Cytolysin IIID; CLY-IIID; Toxin RTX-III secretion protein D [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNASTPRGPAAAESRHPAHLLLQRYADIFRAAWAQRAALAGPPWLADERAFLPAALSLQETPVHPAPRRLAWLVMALFAI
ALVWSIFGRIDIVAVAPGRIIVSDRTKLVQPLENSVVRRVLVREGDHVEAGQPLLELDPTAAHADRTSFGEAHRAAESES
LRVRALQATLAGEAGPGTKLPRWSPQDIPAAWSARERTDAQAQLLAEWSDITARTARLDAERQRREAEIATVRAMVAKLE
TTLPVVRQREADFQTLAAQGFMSGHATQDRMRERVEMERDLATQQARLQEALATLAEARQARMSYLAETRRALSERQAQA
DLKREQNAQELSKAERRERLATLAAPVSGTVQQLAAHTEGGVVTEAQVLMVIVPDGAQVSAEVTLENKDIGFVEPGQDVT
IKLETFPFTRYGTVPAQVETVTRDAVNDEKRGAIFPALLRLGTGHIAVDGKDIRLAPGMNLTAEIKTGQRRVIDYLLSPI
QKAGSESLRER

Sequences:

>Translated_491_residues
MNASTPRGPAAAESRHPAHLLLQRYADIFRAAWAQRAALAGPPWLADERAFLPAALSLQETPVHPAPRRLAWLVMALFAI
ALVWSIFGRIDIVAVAPGRIIVSDRTKLVQPLENSVVRRVLVREGDHVEAGQPLLELDPTAAHADRTSFGEAHRAAESES
LRVRALQATLAGEAGPGTKLPRWSPQDIPAAWSARERTDAQAQLLAEWSDITARTARLDAERQRREAEIATVRAMVAKLE
TTLPVVRQREADFQTLAAQGFMSGHATQDRMRERVEMERDLATQQARLQEALATLAEARQARMSYLAETRRALSERQAQA
DLKREQNAQELSKAERRERLATLAAPVSGTVQQLAAHTEGGVVTEAQVLMVIVPDGAQVSAEVTLENKDIGFVEPGQDVT
IKLETFPFTRYGTVPAQVETVTRDAVNDEKRGAIFPALLRLGTGHIAVDGKDIRLAPGMNLTAEIKTGQRRVIDYLLSPI
QKAGSESLRER
>Mature_491_residues
MNASTPRGPAAAESRHPAHLLLQRYADIFRAAWAQRAALAGPPWLADERAFLPAALSLQETPVHPAPRRLAWLVMALFAI
ALVWSIFGRIDIVAVAPGRIIVSDRTKLVQPLENSVVRRVLVREGDHVEAGQPLLELDPTAAHADRTSFGEAHRAAESES
LRVRALQATLAGEAGPGTKLPRWSPQDIPAAWSARERTDAQAQLLAEWSDITARTARLDAERQRREAEIATVRAMVAKLE
TTLPVVRQREADFQTLAAQGFMSGHATQDRMRERVEMERDLATQQARLQEALATLAEARQARMSYLAETRRALSERQAQA
DLKREQNAQELSKAERRERLATLAAPVSGTVQQLAAHTEGGVVTEAQVLMVIVPDGAQVSAEVTLENKDIGFVEPGQDVT
IKLETFPFTRYGTVPAQVETVTRDAVNDEKRGAIFPALLRLGTGHIAVDGKDIRLAPGMNLTAEIKTGQRRVIDYLLSPI
QKAGSESLRER

Specific function: Involved in the transport of the toxin RTX-III [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 53917; Mature: 53917

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASTPRGPAAAESRHPAHLLLQRYADIFRAAWAQRAALAGPPWLADERAFLPAALSLQE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCC
TPVHPAPRRLAWLVMALFAIALVWSIFGRIDIVAVAPGRIIVSDRTKLVQPLENSVVRRV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHH
LVREGDHVEAGQPLLELDPTAAHADRTSFGEAHRAAESESLRVRALQATLAGEAGPGTKL
HHHCCCCCCCCCCCEEECCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
PRWSPQDIPAAWSARERTDAQAQLLAEWSDITARTARLDAERQRREAEIATVRAMVAKLE
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLPVVRQREADFQTLAAQGFMSGHATQDRMRERVEMERDLATQQARLQEALATLAEARQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMSYLAETRRALSERQAQADLKREQNAQELSKAERRERLATLAAPVSGTVQQLAAHTEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GVVTEAQVLMVIVPDGAQVSAEVTLENKDIGFVEPGQDVTIKLETFPFTRYGTVPAQVET
CEEEEEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHH
VTRDAVNDEKRGAIFPALLRLGTGHIAVDGKDIRLAPGMNLTAEIKTGQRRVIDYLLSPI
HHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCEEEEECCCHHHHHHHHHHHH
QKAGSESLRER
HHHCHHHHHCC
>Mature Secondary Structure
MNASTPRGPAAAESRHPAHLLLQRYADIFRAAWAQRAALAGPPWLADERAFLPAALSLQE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCC
TPVHPAPRRLAWLVMALFAIALVWSIFGRIDIVAVAPGRIIVSDRTKLVQPLENSVVRRV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHH
LVREGDHVEAGQPLLELDPTAAHADRTSFGEAHRAAESESLRVRALQATLAGEAGPGTKL
HHHCCCCCCCCCCCEEECCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
PRWSPQDIPAAWSARERTDAQAQLLAEWSDITARTARLDAERQRREAEIATVRAMVAKLE
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTLPVVRQREADFQTLAAQGFMSGHATQDRMRERVEMERDLATQQARLQEALATLAEARQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMSYLAETRRALSERQAQADLKREQNAQELSKAERRERLATLAAPVSGTVQQLAAHTEG
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GVVTEAQVLMVIVPDGAQVSAEVTLENKDIGFVEPGQDVTIKLETFPFTRYGTVPAQVET
CEEEEEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHH
VTRDAVNDEKRGAIFPALLRLGTGHIAVDGKDIRLAPGMNLTAEIKTGQRRVIDYLLSPI
HHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCEEEEECCCHHHHHHHHHHHH
QKAGSESLRER
HHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8494611; 7927703 [H]